926 research outputs found
Resolved Spectroscopy of the T8.5 and Y0-0.5 Binary WISEPC J121756.91+162640.2AB
We present 0.9 - 2.5 um resolved spectra for the ultracool binary WISEPC
J121756.91+162640.2AB. The system consists of a pair of brown dwarfs that
straddles the currently defined T/Y spectral type boundary. We use synthetic
spectra generated by model atmospheres that include chloride and sulfide clouds
(Morley et al.), the distance to the system (Dupuy & Kraus), and the radius of
each component based on evolutionary models (Saumon & Marley) to determine a
probable range of physical properties for the binary. The effective temperature
of the T8.5 primary is 550 - 600 K, and that of the Y0 - Y0.5 secondary is 450
K. The atmospheres of both components are either free of clouds or have
extremely thin cloud layers. We find that the masses of the primary and
secondary are 30 and 22 M_Jup, respectively, and that the age of the system is
4 - 8 Gyr. This age is consistent with astrometric measurements (Dupuy & Kraus)
that show that the system has kinematics intermediate between those of the thin
and thick disks of the Galaxy. An older age is also consistent with an
indication by the H - K colors that the system is slightly metal-poor.Comment: 21 pages which include 6 Figures and 3 Tables. Accepted on November 8
2013 for publication in Ap
Requirement for the eIF4E Binding Proteins for the Synergistic Down-Regulation of Protein Synthesis by Hypertonic Conditions and mTOR Inhibition.
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity of several proteins that have the potential to control translation, including p70S6 kinase and the eIF4E binding proteins 4E-BP1 and 4E-BP2. In spite of this, in exponentially growing cells overall protein synthesis is often resistant to mTOR inhibitors. We report here that sensitivity of wild-type mouse embryonic fibroblasts (MEFs) to mTOR inhibitors can be greatly increased when the cells are subjected to the physiological stress imposed by hypertonic conditions. In contrast, protein synthesis in MEFs with a double knockout of 4E-BP1 and 4E-BP2 remains resistant to mTOR inhibitors under these conditions. Phosphorylation of p70S6 kinase and protein kinase B (Akt) is blocked by the mTOR inhibitor Ku0063794 equally well in both wild-type and 4E-BP knockout cells, under both normal and hypertonic conditions. The response of protein synthesis to hypertonic stress itself does not require the 4E-BPs. These data suggest that under certain stress conditions: (i) translation has a greater requirement for mTOR activity and (ii) there is an absolute requirement for the 4E-BPs for regulation by mTOR. Importantly, dephosphorylation of p70S6 kinase and Akt is not sufficient to affect protein synthesis acutely
Thermal Emission and Albedo Spectra of Super Earths with Flat Transmission Spectra
Planets larger than Earth and smaller than Neptune are some of the most
numerous in the galaxy, but observational efforts to understand this population
have proved challenging because optically thick clouds or hazes at high
altitudes obscure molecular features (Kreidberg et al. 2014b). We present
models of super Earths that include thick clouds and hazes and predict their
transmission, thermal emission, and reflected light spectra. Very thick, lofted
clouds of salts or sulfides in high metallicity (1000x solar) atmospheres
create featureless transmission spectra in the near-infrared. Photochemical
hazes with a range of particle sizes also create featureless transmission
spectra at lower metallicities. Cloudy thermal emission spectra have muted
features more like blackbodies, and hazy thermal emission spectra have emission
features caused by an inversion layer at altitudes where the haze forms. Close
analysis of reflected light from warm (~400-800 K) planets can distinguish
cloudy spectra, which have moderate albedos (0.05-0.20), from hazy models,
which are very dark (0.0-0.03). Reflected light spectra of cold planets (~200
K) accessible to a space-based visible light coronagraph will have high albedos
and large molecular features that will allow them to be more easily
characterized than the warmer transiting planets. We suggest a number of
complementary observations to characterize this population of planets,
including transmission spectra of hot (>1000 K) targets, thermal emission
spectra of warm targets using the James Webb Space Telescope (JWST), high
spectral resolution (R~10^5) observations of cloudy targets, and reflected
light spectral observations of directly-imaged cold targets. Despite the dearth
of features observed in super Earth transmission spectra to date, different
observations will provide rich diagnostics of their atmospheres.Comment: 23 pages, 23 figures. Revised for publication in The Astrophysical
Journa
Forward and Inverse Modeling of the Emission and Transmission Spectrum of GJ 436b: Investigating Metal Enrichment, Tidal Heating, and Clouds
The Neptune-mass GJ 436b is one of the most-studied transiting exoplanets
with repeated measurements of both its thermal emission and transmission
spectra. We build on previous studies to answer outstanding questions about
this planet, including its potentially high metallicity and tidal heating of
its interior. We present new observations of GJ 436b's thermal emission at 3.6
and 4.5 micron, which reduce uncertainties in estimates of GJ 436b's flux at
those wavelengths and demonstrate consistency between Spitzer observations
spanning more than 7 years. We analyze the Spitzer thermal emission photometry
and Hubble WFC3 transmission spectrum in tandem. We use a powerful dual-pronged
modeling approach, comparing these data to both self-consistent and retrieval
models. We vary the metallicity, intrinsic luminosity from tidal heating,
disequilibrium chemistry, and heat redistribution. We also study the effect of
clouds and photochemical hazes on the spectra, but do not find strong evidence
for either. The self-consistent and retrieval modeling combine to suggest that
GJ 436b has a high atmospheric metallicity, with best fits at or above several
hundred times solar metallicity, tidal heating warming its interior with
best-fit intrinsic effective effective temperatures around 300--350 K, and
disequilibrium chemistry. High metal-enrichments (>600x solar) can only occur
from the accretion of rocky, rather than icy, material. Assuming Tint~300--350
K, we find that Q'~2x10^5--10^6, larger than Neptune's Q', and implying a long
tidal circularization timescale for the planet's orbit. We suggest that
Neptune-mass planets may be a more diverse class than previously imagined, with
metal-enhancements potentially spanning several orders of magnitude, to perhaps
over 1000x solar metallicity. High fidelity observations with instruments like
JWST will be critical for characterizing this diversity.Comment: 15 pages, 18 figures. Revised for publication in Ap
Cross-cultural comparison of genetic and cultural transmission of smoking initiation using an extended twin kinship model
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior. Although twin and adoption designs are powerful to detect genetic and environmental influences, they do not provide information on the processes of assortative mating and parent–offspring transmission and their contribution to the variability explained by genetic and/or environmental factors. Methods: We examined the role of genetic and environmental factors in individual differences for smoking initiation (SI) using an extended kinship design. This design allows the simultaneous testing of additive and non-additive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission, while also estimating the regression of the prevalence of SI on age. A dichotomous lifetime ‘ever’ smoking measure was obtained from twins and relatives in the ‘Virginia 30,000’ sample and the ‘Australian 25,000’. Results: Results demonstrate that both genetic and environmental factors play a significant role in the liability to SI. Major influences on individual differences appeared to be additive genetic and unique environmental effects, with smaller contributions from assortative mating, shared sibling environment, twin environment, cultural transmission, and resulting genotype-environment covariance. Age regression of the prevalence of SI was significant. The finding of negative cultural transmission without dominance led us to investigate more closely two possible mechanisms for the lower parent–offspring correlations compared to the sibling and DZ twin correlations in subsets of the data: (1) age × gene interaction, and (2) social homogamy. Neither of the mechanism provided a significantly better explanation of the data. Conclusions: This study showed significant heritability, partly due to assortment, and significant effects of primarily non-parental shared environment on liability to SI
Does Glyphosate Acting as a Glycine Analogue Contribute To ALS?
 Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease involving several protein mutations in glycine-rich regions with limited treatment options. 90 - 95% of all cases are non-familial with epidemiological studies showing a significant increased risk in glyphosate-exposed workers. In this paper, we propose that glyphosate, the active ingredient in Roundup®, plays a role in ALS, mainly through mistakenly substituting for glycine during protein synthesis, disruption of mineral homeostasis as well as setting up a state of dysbiosis. Mouse models of ALS reveal a pre-symptomatic profile of gut dysbiosis. This dysbiotic state initiate a cascade of events initially impairing metabolism in the gut, and, ultimately, through a series of intermediate stages, leading to motor neuron axonal damage seen in ALS. Lipopolysaccharide, a toxic by-product of dysbiosis which contributes to the pathology, is shown to be statistically higher in ALS patients. In this paper we paint a compelling view of how glyphosate exerts its deleterious effects, including mitochondrial stress and oxidative damage through glycine substitution. Furthermore, its mineral chelation properties disrupt manganese, copper and zinc balance, and it induces glutamate toxicity in the synapse, which results in a die-back phenomenon in axons of motor neurons supplying the damaged skeletal muscles
What do we measure and how do we elicit it? The case for the use of repertory grid technique in multi-party psychological contract research
The psychological contract is a multi-faceted construct and, with the rise of gig work, increasingly the contract extends beyond the conventional employer-employee relationship to encompass multi-party exchanges. Against this backdrop, the question of what should be measured when assessing the contract and how it should be elicited remains a significant issue for scholars. We argue that the potential of psychological contract theory as an explanatory lens in understanding contemporary multi-party working relationships is constrained by two key limitations inherent in conventional measurement approaches. Firstly, such approaches have favoured singular rather than multiparty perspectives, and secondly, they have broadly accorded equal weight and significance to the content dimensions unearthed, despite the fact that they may differ markedly in how they are understood by each party to the employment relationship. In order to remedy these shortcomings, we make the case for adopting repertory grid technique as a methodological framework to address measurement limitations and to more rigorously assess the content of the complex multi-party psychological contract
2010 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations, part 5: adult basic life support
Observed Variability at 1um and 4um in the Y0 Brown Dwarf WISEP J173835.52+273258.9
We have monitored photometrically the Y0 brown dwarf WISEP
J173835.52+273258.9 (W1738) at both near- and mid-infrared wavelengths. This ~1
Gyr-old 400K dwarf is at a distance of 8pc and has a mass around 5 M_Jupiter.
We observed W1738 using two near-infrared filters at lambda~1um, Y and J, on
Gemini observatory, and two mid-infrared filters at lambda~4um, [3.6] and
[4.5], on the Spitzer observatory. Twenty-four hours were spent on the source
by Spitzer on each of June 30 and October 30 2013 UT. Between these
observations, around 5 hours were spent on the source by Gemini on each of July
17 and August 23 2013 UT. The mid-infrared light curves show significant
evolution between the two observations separated by four months. We find that a
double sinusoid can be fit to the [4.5] data, where one sinusoid has a period
of 6.0 +/- 0.1 hours and the other a period of 3.0 +/- 0.1 hours. The
near-infrared observations suggest variability with a ~3.0 hour period,
although only at a <~2 sigma confidence level. We interpret our results as
showing that the Y dwarf has a 6.0 +/- 0.1 hour rotation period, with one or
more large-scale surface features being the source of variability. The
peak-to-peak amplitude of the light curve at [4.5] is 3%. The amplitude of the
near-infrared variability, if real, may be as high as 5 to 30%. Intriguingly,
this size of variability and the wavelength dependence can be reproduced by
atmospheric models that include patchy KCl and Na_2S clouds and associated
small changes in surface temperature. The small number of large features, and
the timescale for evolution of the features, is very similar to what is seen in
the atmospheres of the solar system gas giants.Comment: Accepted by ApJ July 26 2016. Twenty-six pages include 8 Figures and
5 Table
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