106 research outputs found
Bayesian Machine Learning Techniques for revealing complex interactions among genetic and clinical factors in association with extra-intestinal Manifestations in IBD patients
The objective of the study is to assess the predictive performance of three different techniques as classifiers for extra-intestinal manifestations in 152 patients with Crohn's disease. Na\uefve Bayes, Bayesian Additive Regression Trees and Bayesian Networks implemented using a Greedy Thick Thinning algorithm for learning dependencies among variables and EM algorithm for learning conditional probabilities associated to each variable are taken into account. Three sets of variables were considered: (i) disease characteristics: presentation, behavior and location (ii) risk factors: age, gender, smoke and familiarity and (iii) genetic polymorphisms of the NOD2, CD14, TNFA, IL12B, and IL1RN genes, whose involvement in Crohn's disease is known or suspected. Extra-intestinal manifestations occurred in 75 patients. Bayesian Networks achieved accuracy of 82% when considering only clinical factors and 89% when considering also genetic information, outperforming the other techniques. CD14 has a small predicting capability. Adding TNFA, IL12B to the 3020insC NOD2 variant improved the accuracy
Large Interferometer For Exoplanets (LIFE): VIII. Where is the phosphine? Observing exoplanetary PH3 with a space based MIR nulling interferometer
Phosphine could be a key molecule in the understanding of exotic chemistry
happening in (exo)planetary atmospheres. While it has been detected in the
Solar System's giant planets, it has not been observed in exoplanets yet. In
the exoplanetary context however it has been theorized as a potential
biosignature molecule. The goal of our study is to identify which illustrative
science cases for PH3 chemistry are observable with a space-based mid-infrared
nulling interferometric observatory like the LIFE (Large Interferometer For
Exoplanets) concept. We identified a representative set of scenarios for PH3
detections in exoplanetary atmospheres varying over the whole dynamic range of
the LIFE mission. We used chemical kinetics and radiative transfer calculations
to produce forward models of these informative, prototypical observational
cases for LIFEsim, our observation simulator software for LIFE. In a detailed,
yet first order approximation it takes a mission like LIFE: (i) about 1h to
find phosphine in a warm giant around a G star at 10 pc, (ii) about 10 h in H2
or CO2 dominated temperate super-Earths around M star hosts at 5 pc, (iii) and
even in 100h it seems very unlikely that phosphine would be detectable in a
Venus-Twin with extreme PH3 concentrations at 5 pc. Phosphine in concentrations
previously discussed in the literature is detectable in 2 out of the 3 cases
and about an order of magnitude faster than comparable cases with JWST. We show
that there is a significant number of objects accessible for these classes of
observations. These results will be used to prioritize the parameter range for
the next steps with more detailed retrieval simulations. They will also inform
timely questions in the early design phase of a mission like LIFE and guide the
community by providing easy-to-scale first estimates for a large part of
detection space of such a mission.Comment: In press. Accepted for publication in Astrobiology on 02 November
2022. 26 pages, 5 figures and 8 table
Large interferometer for exoplanets: VIII. Where is the phosphine? Observing exoplanetary PH3 with a space-based mid-infrared nulling interferometer
Stars and planetary system
Automated office blood pressure measurements in primary care are misleading in more than one third of treated hypertensives: The VALENTINE-Greece Home Blood Pressure Monitoring study
Abstract Background This study assessed the diagnostic reliability of automated office blood pressure (OBP) measurements in treated hypertensive patients in primary care by evaluating the prevalence of white coat hypertension (WCH) and masked uncontrolled hypertension (MUCH) phenomena. Methods Primary care physicians, nationwide in Greece, assessed consecutive hypertensive patients on stable treatment using OBP (1 visit, triplicate measurements) and home blood pressure (HBP) measurements (7 days, duplicate morning and evening measurements). All measurements were performed using validated automated devices with bluetooth capacity (Omron M7 Intelli-IT). Uncontrolled OBP was defined as â„140/90 mmHg, and uncontrolled HBP was defined as â„135/85 mmHg. Results A total of 790 patients recruited by 135 doctors were analyzed (age: 64.5 ± 14.4 years, diabetics: 21.4%, smokers: 20.6%, and average number of antihypertensive drugs: 1.6 ± 0.8). OBP (137.5 ± 9.4/84.3 ± 7.7 mmHg, systolic/diastolic) was higher than HBP (130.6 ± 11.2/79.9 ± 8 mmHg; difference 6.9 ± 11.6/4.4 ± 7.6 mmHg, p Conclusions In primary care, automated OBP measurements are misleading in approximately 40% of treated hypertensive patients. HBP monitoring is mandatory to avoid overtreatment of subjects with WCH phenomenon and prevent undertreatment and subsequent excess cardiovascular disease in MUCH
Large interferometer for exoplanets (LIFE). I. Improved exoplanet detection yield estimates for a large mid-infrared space-interferometer mission
Stars and planetary system
Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells
La distribuzione degli utili da parte di societĂ soggette ad Irpeg e la percezione da parte dei soci
Il beneficio fiscale della deduzione delle perdite della stabile organizzazione dal reddito imponibile della casa madre residente in altro Stato membro
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