Is blockchain the breakthrough we are looking for to facilitate genomic data sharing? The European Union perspective

The recent progress of genomics research is providing unprecedented insight into human genetic variance, susceptibility to disease and risk stratification. Current trends predict that a massive amount of genomic data will be produced in the upcoming years which, when coupled with the fast-paced development of the field, will create new social, ethical, and legal challenges. In the complex legislative environment of the European Union, genomic data sharing policies will have to weigh the benefits of scientific discovery against the ethical risks posed by the act of sharing sensitive data. In this complex, interconnected environment, blockchain provides a unique and novel solution to accountability, traceability, and transparency issues regarding genomic data sharing. Implementing a distributed ledger technology-based database could empower both patients and citizens to responsibly use genomic data pertaining to them because it allows for a higher degree of control over the recipients of their data and their uses. The blockchain technology will engage both data owners and policymakers to address the multiple issues of genomic data sharing and allow us to redefine the way we look at genomics

A Systematic Review Identifying Adverse Health Outcomes and Mortality Rates Associated with Telehealth

Background: The literature supporting telehealth management is growing accelerated by the COVID-pandemic. We hypothesize that there are risks of adverse events associated with telehealth interventions. Methods: A review of PubMed (including MEDLINE), Embase, ISI (Web of Science), VHL/GHL, Scopus, Science Direct, and PsycINFO was conducted for all adverse events associated with telehealth from January 1, 1960 to March 1, 2021. This systematic review and meta-analyses were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Of 5,144 citations 78 published studies met criteria for quality evaluation and underwent full text abstraction including the qualitative synthesis. Of the 78 included studies 8 were included in the quantitative synthesis resulting in 2 meta-analyses. The results of the meta-analysis suggest that monitoring patients using telehealth techniques is associated with 40% lower mortality risks among patients suffering from heart failure, compared to those who received traditional care. The results of the random-effects meta-analysis showed the pooled relative risk of mortality to be 0.60, indicating that patients that underwent telemonitoring had a lower mortality risk compared with the patients that underwent usual care. Among patients with heart implants, patients who received telemonitoring had a 35% lower mortality risk compared to patients receiving traditional care. Conclusions: While RCTs of telehealth interventions demonstrate enhanced patient outcomes in a number of studies and pave the way to evidence-based practice, the heterogeneity of the research questions suggest an important need for more complementary studies with consistent outcome assessments

Research Into Structure Formation and Properties of the Fiber­reinforced Aerated Concrete Obtained by the Non­autoclaved Hardening

We have investigated the influence of the ratio cement:fly-ash and the temperature of mixing water on the properties of aerated concrete mixes and aerated concrete. It was established that the rational cement-fly ash ratio is 1:1; the mixing water temperature is 40 °C. Experimental research confirmed that the introduction of waste from salt processing and metakaolin to the formulation of binding compositions leads to the formation, rather than the metastable hexagonal calcium hydro-aluminates, of the stable compounds in the structure of partitions between pores of the hydrocalumite and hydrocarboaluminate type. That allowed the targeted structure formation of partitions between pores of the non-autoclaved aerated concrete, which improves the density of partitions and the strength of aerated concrete. It is shown that the introduction of polypropylene fibers to composition of aerated concrete does not affect the kinetics of swelling of the aerated concrete array. However, the introduction of polypropylene fibers improves the strength of aerated concrete based on the modified binding composition containing metakaolin by 47 %, the modified binding composition containing carbonate-containing waste ‒ by 32 %. For the aerated concrete of the В1.5–В2 class of strength, at a density within 615‒625 kg/m3, the estimated coefficient of thermal conductivity is 0.16 W/(m∙K), which makes it possible to reduce heat losses through external enclosures.Thus, there is reason to assert the possibility of the targeted control over the processes of forming a strong structure of partitions between pores using the modified binding compositions containing supplementary cementitious materials. The application of polypropylene fibers enables the reinforcement of aerated -concrete array, forming a strong structural frame of partitions between pores, and ensuring greater strength of the non-autoclaved aerated concrete

Social media and attitudes towards a COVID-19 vaccination: A systematic review of the literature

Background: Vaccine hesitancy continues to limit global efforts in combatting the COVID-19 pandemic. Emerging research demonstrates the role of social media in disseminating information and potentially influencing people's attitudes towards public health campaigns. This systematic review sought to synthesize the current evidence regarding the potential role of social media in shaping COVID-19 vaccination attitudes, and to explore its potential for shaping public health interventions to address the issue of vaccine hesitancy. Methods: We performed a systematic review of the studies published from inception to 13 of March2022 by searching PubMed, Web of Science, Embase, PsychNET, Scopus, CINAHL, and MEDLINE. Studies that reported outcomes related to coronavirus disease 2019 (COVID-19) vaccine (attitudes, opinion, etc.) gathered from the social media platforms, and those analyzing the relationship between social media use and COVID-19 hesitancy/acceptance were included. Studies that reported no outcome of interest or analyzed data from sources other than social media (websites, newspapers, etc.) will be excluded. The Newcastle Ottawa Scale (NOS) was used to assess the quality of all cross-sectional studies included in this review. This study is registered with PROSPERO (CRD42021283219). Findings: Of the 2539 records identified, a total of 156 articles fully met the inclusion criteria. Overall, the quality of the cross-sectional studies was moderate - 2 studies received 10 stars, 5 studies received 9 stars, 9 studies were evaluated with 8, 12 studies with 7,16 studies with 6, 11 studies with 5, and 6 studies with 4 stars. The included studies were categorized into four categories. Cross-sectional studies reporting the association between reliance on social media and vaccine intentions mainly observed a negative relationship. Studies that performed thematic analyses of extracted social media data, mainly observed a domination of vaccine hesitant topics. Studies that explored the degree of polarization of specific social media contents related to COVID-19 vaccines observed a similar degree of content for both positive and negative tone posted on different social media platforms. Finally, studies that explored the fluctuations of vaccination attitudes/opinions gathered from social media identified specific events as significant cofactors that affect and shape vaccination intentions of individuals. Interpretation: This thorough examination of the various roles social media can play in disseminating information to the public, as well as how individuals behave on social media in the context of public health events, articulates the potential of social media as a platform of public health intervention to address vaccine hesitancy. Funding: None

Improving the Energy Performance of Enterprises for Repair of Rolling Stock

Улучшение энергетических показателей предприятий по ремонту подвижного состава: [Препринт] / Л. В. Дубинец, О. Л. Маренич, О. А. Карзова, Р. В. Краснов, А. А. Мельник // Гірнича електромеханіка та автоматика: Наук.-техн. зб. / Державний ВНЗ «НГУ». – 2013. – Вип. 90. – С. 144-150.RU: В статье проведено исследование по определению эффективности улучшения энергетических показателей нерегулируемых электроприводов с асинхронными двигателями, что используются на предприятиях по ремонту подвижного состава, способом переключения из схемы соединения обмоток статора «треугольник» на схему соединения «звезда».UK: У статті проведено дослідження по визначенню ефективності покращення енергетичних показників нерегулюємих електроприводів з асинхронними двигунами, що використовуються на підприємствах по ремонту рухомого складу, способом перемикання зі схеми з’єднання обмоток статора «трикутник» на схему з’єднання «зірка».EN: The paper conducted a study to determine the effectiveness of improving energy performance of non-regulated electric induction motors that are used by companies to repair rolling stock, the method of circuit switching connection of the stator windings "triangle" on the wiring diagram "star.

Preparation of 5‑Fluoropyrazoles from Pyrazoles and <i>N</i>‑Fluoro­benzene­sulfonimide (NFSI)

Facile synthesis of 5-fluoropyrazoles by direct fluorination of pyrazoles with <i>N</i>-fluoro­benzene­sulfonimide (NFSI) was elaborated. This approach was used to prepare the unsubstituted 5-fluoro-1<i>H</i>-pyrazole, the known fungicide <i>Penflufen</i>, and many functionalized 5-fluoropyrazoles: building blocks for medicinal chemistry and agrochemistry