Table_1_Impact of free hypertension pharmacy program and social distancing policy on stroke: A longitudinal study.DOCX

BackgroundThe estimated lifetime risk of stroke was the highest in East Asia worldwide, especially in China. Antihypertensive therapy can significantly reduce stroke mortality. However, blood pressure control is poor. Medication adherence is a barrier as patients’ out-of-pocket costs have risen. We aimed to take advantage of a free hypertension pharmacy intervention and quantified the impact on stroke mortality.MethodsA free pharmaceutical intervention program was implemented in Deqing, Zhejiang province in April 2018. Another non-pharmaceutical intervention, social distancing due to the pandemic of Coronavirus disease 2019 (COVID-19), was also key to affecting stroke mortality. We retrospectively collected the routine surveillance data of stroke deaths from Huzhou Municipal Center for Disease Prevention and Control in 2013–2020 and obtained within-city mobility data from Baidu Migration in 2019–2020, then we quantified the effects of both pharmaceutical intervention and social distancing using Serfling regression model.ResultsCompared to the predicted number, the actual number of stroke deaths was significantly lower by 10% (95% CI, 6–15%; p ConclusionFree hypertension pharmacy program has great potential to prevent considerable stroke deaths. In the future, the free supply of low-cost, essential medications that target patients with hypertension at increased risk of stroke could be taken into account in formulating public health policies and guiding allocations of health care resources.</p

Additional file 1: Figure S1. of Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

Characterization of sphere cell forming cells cultured from colon cancer cell line HCT-116. Figure S2. Self-renewal gene expressions of Îł-T3 treated HeLa spherical cells. (DOCX 167 kb

I dubbi sull’attuale rilevanza dei Gruppi di Imprese nel diritto del lavoro. Le oscillazioni della giurisprudenza e la necessità di un intervento organico del Legislatore in materia

Mesostructured hollow carbon nanoparticles have widespread applications. A big challenge in materials science is surfactant-free synthesis of hollow carbon nanoparticles with tunable mesostructures. Herein we report a new surfactant-free sequential heterogeneous nucleation pathway to prepare mesostructured hollow carbon nanoparticles. This strategy relies on two polymerizable systems, i.e., resorcinol formaldehyde and tetraethyl orthosilicate, each of which undergoes homogeneous nucleation and particle growth. By controlling the polymerization kinetics of two systems when mixed together, sequential heterogeneous nucleation can be programmed, leading to monodispersed and mesostructured hollow carbon nanoparticles with large mesopores, controllable mesostructures (bi- and triple-layered), and rich morphologies (invaginated, intact, and endoinvaginated spheres). For the first time, it is demonstrated that the invaginated structure shows better hemocompatibility compared to the intact one. The pristine hollow carbon nanoparticles with large pore size and high pore volume show the high loading capacity of biomolecules and successfully deliver biomolecules into cells. Our strategy has paved the way for the designed synthesis of unprecedented carbon nanostructures with potential applications in drug/biomolecule delivery

An Approach to Prepare Polyethylenimine Functionalized Silica-Based Spheres with Small Size for siRNA Delivery

A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of ∼10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents

Stepwise Pore Size Reduction of Ordered Nanoporous Silica Materials at Angstrom Precision

A facile vacuum-assisted vapor deposition process has been developed to control the pore size of ordered mesoporous silica materials in a stepwise manner with angstrom precision, providing an unprecedented paradigm for screening a designer hydrophobic drug nanocarrier with optimized pore diameter to maximize drug solubility

Synthesis of Nonspherical Mesoporous Silica Ellipsoids with Tunable Aspect Ratios for Magnetic Assisted Assembly and Gene Delivery

Despite the extensive application of ellipsoidal micro-/nanoparticles, the synthesis of shape anisotropic ellipsoids is rare because of the minimization of surface free energy that favors simple spherical shape rather than complex nonspherical shape. We present the synthesis of silica ellipsoids with hexagonal mesostructure via the organic–inorganic cooperative assembly in the presence of cosolvents (KCl and ethanol). The aspect ratio of ellipsoids can be tuned systematically by controlling the concentration of ethanol. Transmission electron microscopy (TEM) shows that the ellipsoid possesses one-dimensional (1-D) pore channels parallel to the major axis, and the electron tomography (ET) technique shows that the ellipsoid has indeed hexagonal prism morphology in the middle and ellipsoidal morphology at two tips. A mechanism for the formation of mesoporous silica ellipsoids has been proposed. Importantly, magnetite/silica composite ellipsoids were prepared through a nanocasting route and can be used as building blocks to organize into ordered arrays in response to an external magnetic field. In addition, after functionalized with amino-groups, the amino-modified anisotropic magnetite/silica ellipsoids can be further used as carriers for delivering oligo-DNA-Cy3 into tumor cells, showing potential in directed self-assembly and drug/gene delivery

Synthesis of Nonspherical Mesoporous Silica Ellipsoids with Tunable Aspect Ratios for Magnetic Assisted Assembly and Gene Delivery

Despite the extensive application of ellipsoidal micro-/nanoparticles, the synthesis of shape anisotropic ellipsoids is rare because of the minimization of surface free energy that favors simple spherical shape rather than complex nonspherical shape. We present the synthesis of silica ellipsoids with hexagonal mesostructure via the organic–inorganic cooperative assembly in the presence of cosolvents (KCl and ethanol). The aspect ratio of ellipsoids can be tuned systematically by controlling the concentration of ethanol. Transmission electron microscopy (TEM) shows that the ellipsoid possesses one-dimensional (1-D) pore channels parallel to the major axis, and the electron tomography (ET) technique shows that the ellipsoid has indeed hexagonal prism morphology in the middle and ellipsoidal morphology at two tips. A mechanism for the formation of mesoporous silica ellipsoids has been proposed. Importantly, magnetite/silica composite ellipsoids were prepared through a nanocasting route and can be used as building blocks to organize into ordered arrays in response to an external magnetic field. In addition, after functionalized with amino-groups, the amino-modified anisotropic magnetite/silica ellipsoids can be further used as carriers for delivering oligo-DNA-Cy3 into tumor cells, showing potential in directed self-assembly and drug/gene delivery

Synthesis of Nonspherical Mesoporous Silica Ellipsoids with Tunable Aspect Ratios for Magnetic Assisted Assembly and Gene Delivery

Despite the extensive application of ellipsoidal micro-/nanoparticles, the synthesis of shape anisotropic ellipsoids is rare because of the minimization of surface free energy that favors simple spherical shape rather than complex nonspherical shape. We present the synthesis of silica ellipsoids with hexagonal mesostructure via the organic–inorganic cooperative assembly in the presence of cosolvents (KCl and ethanol). The aspect ratio of ellipsoids can be tuned systematically by controlling the concentration of ethanol. Transmission electron microscopy (TEM) shows that the ellipsoid possesses one-dimensional (1-D) pore channels parallel to the major axis, and the electron tomography (ET) technique shows that the ellipsoid has indeed hexagonal prism morphology in the middle and ellipsoidal morphology at two tips. A mechanism for the formation of mesoporous silica ellipsoids has been proposed. Importantly, magnetite/silica composite ellipsoids were prepared through a nanocasting route and can be used as building blocks to organize into ordered arrays in response to an external magnetic field. In addition, after functionalized with amino-groups, the amino-modified anisotropic magnetite/silica ellipsoids can be further used as carriers for delivering oligo-DNA-Cy3 into tumor cells, showing potential in directed self-assembly and drug/gene delivery