An Approach
to Prepare Polyethylenimine
Functionalized Silica-Based Spheres with Small Size for siRNA Delivery
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Abstract
A novel approach has been developed
to prepare polyethylenimine functionalized hybrid silica spheres with
a diameter of ∼10 nm, which show excellent delivery efficiency
of siRNA into osteosarcoma cancer cells and human colon cancer cells
with a significant cell inhibition comparable to commercial agents