Newton for ladies: gentility, gender and radical culture

© British Society for the History of ScienceFrancesco Algarotti’s Newtonianism for Ladies (1737), a series of lively dialogues on optics, was a landmark in the popularization of Newtonian philosophy. In this essay I shall explore Algarotti’s sociocultural world, his aims and ambitions, and the meaning he attached to his own work. In particular I shall focus on Algarotti’s self-promotional strategies, his deployment of gendered images and his use of popular philosophy within the broader cultural and experimental campaign for the success of Newtonianism. Finally, I shall suggest a radical reading of the dialogues, reconstructing the process that brought them to their religious condemnation. What did Newtonianism mean to Algarotti? In opposition to mainstream apologetic interpretations, he seems to have framed the new experimental methodology in a sensationalistic epistemology derived mainly from Locke, pointing at a series of subversive religious and political implications. Due to the intervention of religious authorities Algarotti’s radical Newtonianism became gradually less visible in subsequent editions and translations. It is only through the study of the first – clandestine – edition of the dialogues that one can begin reconstructing the meaning of Algarotti’s experiments (real and fictional) and his cultural battle for a regenerated Europe

Enlightened mills: mechanizing olive oil production in Mediterranean Europe

© 2004 by the Society for the History of Technolog

The two Newtons and beyond

© 2007 British Society for the History of Science. Essay review

For science and for the Pope-king: writing the history of the exact sciences in nineteenth-century Rome

© 2000 British Society for the History of ScienceThis paper analyses the contents and the style of the Bullettino di bibliografia e di storia delle scienze matematiche e fisiche (1868–1887), the first journal entirely devoted to the history of mathematics. It is argued that its innovative and controversial methodological approach cannot be properly understood without considering the cultural conditions in which the journal was conceived and realized. The style of the Bullettino was far from being the mere outcome of the eccentric personality of its editor, Prince Baldassarre Boncompagni. Rather, it reflected in many ways, at the level of historiography of science, the struggle of the official Roman Catholic culture against the growing secularization of knowledge and society

Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

The Simulated Moving Bed process and its recent extensions called Varicol, PowerFeed and ModiCon are studied, in the case where a small number of columns are used, i.e. from three to five. A multiobjective optimization approach, using genetic algorithms and a detailed model of the multicolumn chromatographic process, is applied to optimize each process separately, and allow for comparison of the different operating modes. The non-standard SMB processes achieve better performance than SMB, due to the availability of more degrees of freedom in the operating conditions of the process, namely the way to carry out asynchronous switches for Varicol, and the different flow rates and feed concentration during the switching interval for PowerFeed and for ModiCon, respectively. We also consider the possibility of combining two non-standard operating modes in a new hybrid process, and evaluate also in this case the possible performance. Finally, a critical assessment of the results obtained and of the potential for practical implementation of the different techniques is reporte

Optimizing control of simulated moving bed separations ofmixtures subject to the generalized Langmuir isotherm

Simulated moving bed (SMB) is a cost-efficient separation technique that offers high productivity and low solvent consumption. SMB has gained importance in the pharmaceutical and fine chemical industry to perform complex separation tasks. However, an open and challenging problem is the optimal, robust operation of the SMB process. We have developed a control scheme that integrates the optimization and control of the SMB unit. A significant feature of the controller is that only minimal information of the system has to be provided, i.e. the linear adsorption behavior of the mixture to be separated and the average void fraction of the columns. Therefore, a full characterization of the adsorption behavior of the mixture and the columns is no longer required. In this ‘cycle to cycle' control scheme, the measurements, optimization and control actions are performed once in every cycle. This paper presents simulation results of the control scheme applied to the separation of binary mixtures characterized by generalized Langmuir isotherms. The results are presented and analyzed in the frame of the triangle theory that has been recently extended to encompass these types of isotherms. Besides, online optimum performance of the SMB unit is compared with off-line optimization carried out using genetic algorithm. The results show that the controller fulfills the product and process specifications while operating the SMB unit optimally, regardless of the different types of Langmuir isotherms that the systems exhibi

SMB Operation for Three-Fraction Separations: Purification of Plasmid DNA

The Simulated Moving Bed technology is extended to incorporate a cleaning in place step, and it is then applied by exploiting size exclusion chromatography to purify plasmid DNA. Experimental performances are discussed in the light of our theoretical understanding of the SMB behavio

Automatic Control of Simulated Moving Beds—Experimental Verification

Simulated moving bed (SMB) chromatography has become the state of the art technology applied for the complex separation tasks in the pharmaceutical and fine chemical industry. Nevertheless, operation of SMB units at their optimal operating conditions is still an issue challenging SMB practitioners due to absence of proper process control schemes. We have developed a feedback control scheme that integrates the on-line optimization and control of SMB units. A significant feature of the developed SMB control concept is that only a minimum of system information has to be provided, i.e., the average packing characteristics of the SMB columns and the linear adsorption isotherm, regardless of the type of isotherm characterizing the mixture to be separated. Therefore a detailed characterization of the columns and the separation system is no longer required. This paper demonstrates the experimental implementation of this control concept and presents results referring to two different experimental run