952 research outputs found

    Use of Role-play and Gamification in a Software Project Course

    Get PDF
    Soft skills are increasingly important to the engineering profession and course modifications are often needed to ensure students have opportunities to practice them prior to graduation. This suggests that engineering programs need to go beyond simply offering industry-based capstone courses and internships. Role-play has a long history as a tool for learning. It can be used to simulate real world practices in environments where consequences can be mitigated safely. In this paper, we discuss the use of team role-play activities to simulate the experience of working in a professional, game development studio as a means of enhancing an advanced undergraduate game design course. In conjunction with the role-play, a gamification framework was used within the course to allow students to customize their course participation. Gamification was used to reward students for compliance with software process steps and for taking the initiative to improve their “soft skills”. In this project, allowing students to negotiate the nature of their activities and rewards helped them develop those skills. We are using student feedback and our own lessons learned to plan the next iteration of this course

    Coarse Graining RNA Nanostructures for Molecular Dynamics Simulations

    Get PDF
    A series of coarse-grained models have been developed for the study of the molecular dynamics of RNA nanostructures. The models in the series have one to three beads per nucleotide and include different amounts of detailed structural information. Such a treatment allows us to reach, for the systems of thousands of nucleotides, a time scale of microseconds (i.e. by three orders of magnitude longer than in the full atomistic modelling) and thus to enable simulations of large RNA polymers in the context of bionanotechnology. We find that the 3-beads-per-nucleotide models, described by a set of just a few universal parameters, are able to describe different RNA conformations and are comparable in structural precision to the models where detailed values of the backbone P-C4' dihedrals taken from a reference structure are included. These findings are discussed in the context of the RNA conformation classes

    Evolution of the afterglow optical spectral shape of GRB 201015A in the first hour: evidence for dust destruction

    Full text link
    Instruments such as the ROTSE, TORTORA, Pi of the Sky, MASTER-net, and others have recorded single-band optical flux measurements starting as early as ∌\thicksim 10 seconds after a gamma-ray burst trigger. The earliest measurements of optical spectral shape have been made only much later, typically on hour time scales, never starting less than a minute after trigger, until now. Beginning only 58 seconds after the Swift BAT triggerred on GRB201015A, we observed a sharp rise in flux to a peak, followed by an approximate power law decay light curve, ∝t−0.81±0.03\propto t^{-0.81 \pm 0.03}. Flux was measured simultaneously in three optical filter bands, g', r', and i', using our unique instrument mounted on the Nazarbayev University Transient Telescope at Assy-Turgen Astrophysical Observatory (NUTTelA-TAO). Our simultaneous multi-band observations of the early afterglow show strong colour evolution from red to blue, with a change in the optical log slope (after correction for Milky Way extinction) of +0.72±0.14+0.72 \pm 0.14; during this time the X-ray log slope remained constant. We did not find evidence for a two-component jet structure or a transition from reverse to forward shock that would explain this change in slope. We find that the majority of the optical spectral slope evolution is consistent with a monotonic decay of extinction, evidence of dust destruction. If we assume that the optical log slope is constant throughout this period, with the value given by the late-time slope, and we further assume an SMC-like extinction curve, we derive a change in the local extinction AvlocalA_\mathrm{v}^\mathrm{local} from ∌\thicksim0.8 mag to 0.3 mag in ∌\thicksim2500 s. This work shows that significant information about the early emission phase (and possibly prompt emission, if observed early enough) is being missed without such early observations with simultaneous multi-band instruments.Comment: 7 pages, 3 figures. Submitted to MNRA

    Lung epithelial signaling mediates early vaccine-induced CD4 + T cell activation and Mycobacterium tuberculosis control

    Get PDF
    Tuberculosis (TB) is one of the leading causes of death due to a single infectious agent. The development of a TB vaccine that induces durable and effective immunity to Mycobacterium tuberculosis
    • 

    corecore