4,906 research outputs found
Shadowing Ministers: Monitoring Partners in Coalition Governments
In this article the authors study delegation problems within multiparty coalition
governments. They argue that coalition parties can use the committee system to
âshadowâ the ministers of their partners; that is, they can appoint committee
chairs from other governing parties, who will then be well placed to monitor
and/or check the actions of the corresponding ministers. The authors
analyze which ministers should be shadowed if governing parties seek to
minimize the aggregate policy losses they suffer as the result of ministers pursuing
their own partiesâ interests rather than the coalitionâs. Based on data
from 19 mostly European parliamentary democracies, the authors find that the
greater the policy disagreement between a ministerâs party and its partners,
the more likely the minister is to be shadowed
Orbital operations study. Appendix B: Operational procedures
Operational procedures for each alternate approach for each interfacing activity of the orbital operations study are presented. The applicability of the procedures to interfacing element pairs is identified
A Zero-Positive Learning Approach for Diagnosing Software Performance Regressions
The field of machine programming (MP), the automation of the development of software, is making notable research advances. This is, in part, due to the emergence of a wide range of novel techniques in machine learning. In this paper, we apply MP to the automation of software performance regression testing. A performance regression is a software performance degradation caused by a code change. We present AutoPerfâa novel approach to automate regression testing that utilizes three core techniques:(i) zero-positive learning,(ii) autoencoders, and (iii) hardware telemetry. We demonstrate AutoPerfâs generality and efficacy against 3 types of performance regressions across 10 real performance bugs in 7 benchmark and open-source programs. On average, AutoPerf exhibits 4% profiling overhead and accurately diagnoses more performance bugs than prior state-of-the-art approaches. Thus far, AutoPerf has produced no false negatives
Spin-dependent electrical transport in ion-beam sputter deposited Fe-Cr multilayers
The temperature dependence of the electrical resistivity and
magnetoresistance of Xe-ion beam sputtered Fe-Cr multilayers has been
investigated. The electrical resistivity between 5 and 300 K in the fully
ferromagnetic state, obtained by applying a field beyond the saturation field
(H_sat) necessary for the antiferromagnetic(AF)-ferromagnetic(FM) field-induced
transition, shows evidence of spin-disorder resistivity as in crystalline Fe
and an s-d scattering contribution (as in 3d metals and alloys). The sublattice
magnetization m(T) in these multilayers has been calculated in terms of the
planar and interlayer exchange energies. The additional spin-dependent
scattering \Delta \rho (T) = \rho(T,H=0)_AF - \rho(T,H=H_sat)_FM in the AF
state over a wide range of temperature is found to be proportional to the
sublattice magnetization, both \Delta \rho(T) and m(T) reducing along with the
antiferromagnetic fraction. At intermediate fields, the spin-dependent part of
the electrical resistivity (\rho_s (T)) fits well to the power law \rho_s (T) =
b - cT^\alpha where c is a constant and b and \alpha are functions of H. At low
fields \alpha \approx 2 and the intercept b decreases with H much the same way
as the decrease of \Delta \rho (T) with T. A phase diagram (T vs. H_sat) is
obtained for the field- induced AF to FM transition. Comparisons are made
between the present investigation and similar studies using dc magnetron
sputtered and molecular beam epitaxy (MBE) grown Fe-Cr multilayers.Comment: 8 pages, 10 figures, to appear in Phys. Rev.
Creating and Sharing Digital Instructional Activities: A Practical Tutorial
BCBAs may encounter situations, such as the current COVID-19 pandemic, that preclude them from providing traditional in-person ABA services to clients. When conditions prevent BCBAs and behavior technicians from working directly with clients, digital instructional activities designed by BCBAs and delivered via a computer or tablet may be a viable substitute. Google applications, including Google Slides, Google Forms, and Google Classroom, can be particularly useful for creating and sharing digital instructional activities. In the current paper, we provide task analyses for utilizing basic Google Slides functions, developing independent instructional activities, developing caregiver-supported instructional activities, and sharing activities with clients and caregivers. We also provide practical recommendations for implementing digital instructional activities with clients and caregivers
Off-Equilibrium Dynamics in Finite-Dimensional Spin Glass Models
The low temperature dynamics of the two- and three-dimensional Ising spin
glass model with Gaussian couplings is investigated via extensive Monte Carlo
simulations. We find an algebraic decay of the remanent magnetization. For the
autocorrelation function a typical
aging scenario with a scaling is established. Investigating spatial
correlations we find an algebraic growth law of
the average domain size. The spatial correlation function scales with . The sensitivity of the
correlations in the spin glass phase with respect to temperature changes is
examined by calculating a time dependent overlap length. In the two dimensional
model we examine domain growth with a new method: First we determine the exact
ground states of the various samples (of system sizes up to )
and then we calculate the correlations between this state and the states
generated during a Monte Carlo simulation.Comment: 38 pages, RevTeX, 14 postscript figure
Open questions in the social lives of viruses
Social interactions among viruses occur whenever multiple viral genomes infect the same cells, hosts, or populations of hosts. Viral social interactions range from cooperation to conflict, occur throughout the viral world, and affect every stage of the viral lifecycle. The ubiquity of these social interactions means that they can determine the population dynamics, evolutionary trajectory, and clinical progression of viral infections. At the same time, social interactions in viruses raise new questions for evolutionary theory, providing opportunities to test and extend existing frameworks within social evolution. Many opportunities exist at this interface: Insights into the evolution of viral social interactions have immediate implications for our understanding of the fundamental biology and clinical manifestation of viral diseases. However, these opportunities are currently limited because evolutionary biologists only rarely study social evolution in viruses. Here, we bridge this gap by (1) summarizing the ways in which viruses can interact socially, including consequences for social evolution and evolvability; (2) outlining some open questions raised by viruses that could challenge concepts within social evolution theory; and (3) providing some illustrative examples, data sources, and conceptual questions, for studying the natural history of social viruses
Curcumin requires tumor necrosis Factor α signaling to alleviate cognitive impairment elicited by Lipopolysaccharide
A decline in cognitive ability is a typical feature of the normal aging process, and of neurodegenerative disorders such as Alzheimerâs, Parkinsonâs and Huntingtonâs diseases. Although their etiologies differ, all of these disorders involve local activation of innate immune pathways and associated inflammatory cytokines. However, clinical trials of anti-inflammatory agents in neurodegenerative disorders have been disappointing, and it is therefore necessary to better understand the complex roles of the inflammatory process in neurological dysfunction. The dietary phytochemical curcumin can exert anti-inflammatory, antioxidant and neuroprotective actions. Here we provide evidence that curcumin ameliorates cognitive deficits associated with activation of the innate immune response by mechanisms requiring functional tumor necrosis factor α receptor 2 (TNFR2) signaling. In vivo, the ability of curcumin to counteract hippocampusdependent spatial memory deficits, to stimulate neuroprotective mechanisms such as upregulation of BDNF, to decrease glutaminase levels, and to modulate N-methyl- D âaspartate receptor levels was absent in mice lacking functional TNFRs. Curcumin treatment protected cultured neurons against glutamate-induced excitotoxicity by a mechanism requiring TNFR2 activation. Our results suggest the possibility that therapeutic approaches against cognitive decline designed to selectively enhance TNFR2 signaling are likely to be more beneficial than the use of anti-inflammatory drugs per se.Intramural Research Program of the National Institute on Aging of the National Institutes of HealthFundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo-FAPES
Aging and memory effects in beta-hydrochinone-clathrate
The out-of-equilibrium low-frequency complex susceptibility of the
orientational glass methanol(73%)-beta-hydrochinone-clathrate is studied using
temperature-stop protocols in aging experiments . Although the material does
not have a sharp glass transition aging effects including rejuvenation and
memory are found at low temperatures. However, they turn out to be much weaker,
however, than in conventional magnetic spin glasses.Comment: 5 pages RevTeX, 6 eps-figures include
Validating a generic cancer consumer quality index in eight European countries, patient reported experiences and the influence of cultural differences
BackgroundTaking patient centeredness into account is important in healthcare. The European Cancer Consumer Quality Index (ECCQI) is a validated tool for international benchmarking of patient experiences and satisfaction.This study aimed to further validate the ECCQI in larger and more uniform groups of high volume tumours such as breast and prostate cancer. A second objective was the verification of the influence of cultural factors of the country to determine its possible use in international benchmarking.MethodsData from two survey studies in eight European countries were combined. Socio-demographic correlations were analysed with Kruskall-Wallis and Mann-Whitney tests. Cronbach's alpha was calculated to validate internal consistency. Influences of masculinity (MAS), power distance (PD) and uncertainty avoidance (UA) were determined by linear regression analysis in a general model and subgroup models.ResultsA total of 1322 surveys were included in the analysis (1093 breast- and 348 prostate cancer patients). Cronbach's alpha was good (alpha >= 0.7) or acceptable (0.5Peer reviewe
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