Comparison of pH and Flow Rate of Saliva After Using Black Tea, Green Tea and Coffee in Periodontal Patients and Normal Group

Objectives: Periodontal pathogens need acidic environments to proliferate in periodontium, and their growth is affected by the salivary flow rate and pH of the mouth. Alterations in flow and acidity of saliva have an important effect on oral diseases such as periodontitis. This study was designed to compare salivary pH and flow rate before and after using green tea, black tea and coffee in patients with periodontitis and healthy subjects.Methods: The present case control study was conducted on 60 subjects that were allocated into two groups: 30 subjects without periodontitis and 30 subjects with chronic periodontitis. Gingival index (GI), plaque index (PI), probing depth (PD) and clinical attachment loss (CAL) were recorded. Next, 5mL of saliva from both groups was collected for analysis before and after green tea, black tea and coffee rinsing and salivary pH and flow rate were recorded.Results: The result showed significant increase in salivary flow rate and pH after rinsing of green tea in periodontitis group but there was no significant change in pH and flow rate after rinsing of black tea and coffee in both groups.Conclusion: The results suggest that green tea causes a significant increase in salivary flow rate and pH and seems to be a safe and applicable adjunct treatment for periodontitis

Investigating the Types of E-Advertising Strategy and its Influence on Consumer Buying Behavior

Advertising is a way of communication to convince an audience for taking purchase decision about a product or service and delivering information to viewers. This paper examines the relationship between environmental response and emotional response which are independent variables with dependent variable i.e. consumer buying behavior. This research investigates the relationship between the variables involved, by taking the 120 responses in Iran country. And its show that banner advertising is more effective than other ways of advertisings, and have great effect on consumer purchase decision on internet. Findings of this study show the moderate relationship between independent variables and dependent variableThis study reports new results in the field of buying behavior of consumers’ response. the extent and variety of online advertising  isadvertising is growing dramatically. Business are spending more than before on online advertising. Understanding that what factors in online advertising have effect on consumer purchasing behavior is vital. So, Thethe purpose of research was to study the effect of online advertising strategy on the buying patterns of consumers and to see what factors influence a consumer’s purchase. Keywords: e- Advertising Strategy, Environmental response, Emotional response, Consumer buying behavio

Changes of the Posterior Airway Space Following Orthognathic Surgery in Class III

Objective: Adaptation of the pharyngeal airway space does occur after different surgical strategies of class III patients including mandibular setback, maxillary advancement and bimaxillary surgery. The aim of this study is to conduct a detailed cephalometric evaluation of the alterations taking place in the morphology of the pharyngeal airway space after treatment of class III skeletal deformity via different surgical procedures (i.e. mandibular setback, maxillary advancement, bimaxillary surgery) in both males and females.Methods: This study is a before-after cross sectional retrospective research. One hundred and twenty consecutive patients who were diagnosed as having skeletal class III deformity. All patients included in this study were adults who had completed their growth and had cephalograms within a month  prior to operation (T1) and 1 month to 9 months post-surgery (T2) taken in the natural head position. Patients were divided according to the type of surgery undertaken in three groups: group 1 (bimaxillary), group 2 (mandibular setback) and group 3 (maxillary advancement) surgeries. Posterior airway size was evaluated at both T1 and T2 in each group. The results were compared by paired t and one-way ANOVA tests.Results: Airway size decreased significantly in group 1 and 2 (p<0.05) but increased in group 3(p<0.05).Conclusion: Airway dimension and morphology as well as head and neck posture changed significantly in different surgical treatments of class III deformity

Comparison of the Effects of Local Injection and Oral Intake of Diclofenac and Atorvastatin in Alveolar Bone Density Assessed with CT in Experimental Periodontitis in Rat

Objectives The first cause of tooth loss in developed countries is periodontitis. Chronic periodontitis is the most common form of periodontitis and it is characterized by loss of periodontal attachment, destruction of alveolar bone and eventual loss of teeth. Atorvastatin is a statin drug used for the treatment of high cholesterol. Statins can stop the inflammatory process by inhibiting the cholesterol pathway. Diclofenac is an NSAID with anti-inflammatory, anti-pyretic and analgesic effects. Its primary mechanism is through the inhibition of prostaglandins synthesis by the inhibition of the cyclooxygenase enzyme (COX). The purpose of this study is to compare the effects of local injected and oral intake of Diclofenac and atorvastatin on alveolar bone density measured in HUs with the use of a CT scan in a periodontitis-induced model in rats.Methods Thirty rats were randomly divided into 6 groups of 5 rats each. Ligatures were placed around the left second maxillary molar to induce periodontitis for 10 days. Administration of 12.5 mg/kg of oral atorvastatin (group 1), 0.25 mg/kg of injectable atorvastatin (group 2), 7.5mg/kg of oral Diclofenac (group 3), 6.25mg/kg of injectable Diclofenac (group 4), the oral solvent without medicine as oral control (groups 5), and the injectable solvent without medicine as injectable control (group 6). In each group, the right side of maxilla was considered as control group (without ligature and drug interaction). At day eleven, the rats were sacrificed and the maxillary bone was separated from the soft tissue and fixed in 4% formalin. The prepared samples were then radiologically evaluated to determine the bone density with CT in fixed exposure conditions.Results There was a statistically significant difference between the alveolar bone density of the oral atorvastatin group and the oral Diclofenac (P = 0.006). There was no statistical significant difference in alveolar bone density between the injectable atorvastatin and the injectable Diclofenac groups (P=0.228).Conclusion Both atorvastatin and Diclofenac have shown better results when assessing bone density in a periodontitis rat model  as compared to controls. Additionally, Diclofenac has been shown to be more effective at both oral and injectable administrations as compared with atorvastatin in the prevention of loss of bone density in a rat model with periodontitis

Effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats

Objectives The first cause of tooth loss in developed countries is periodontitis and mostly occurs in people over 40 years old.Atorvastatin is a statin drug class, which has a revolutionary impact on the treatment of high cholesterol and also stimulates bone morphogenic protein which has osteogenic potential. The aim of this study was to evaluate the effect of local and systemic Atorvastatin in the treatment of periodontitis.Materials and Methods Forty eight Sprague Dawley rats were randomly divided into six groups of eight in each; experimental periodontitis was induced by ligature in five of them in each group daily (1) systemic Atorvastatin 12.5 mg/kg (2) systemic solvent (3) local Atorvastatin0.25 mg/kg (4) local solvent (5) no drug was administered and group (6) left non-ligated, and rats were sacrificed on 11th day. Histopathological analysis on periodontal tissue; malondialdehyde (MDA) and superoxide dismutase (SOD) tests on serum were performed to investigate bone loss and inflammation. The statistical tests for MDA and SOD samples were one-way ANOVA with Duncan post-hoc whereas in histopathological samples nonparametric Kruskal–Wallis and Mann–Whitney tests were used.Results Although local injection and oral administration of Atorvastatin significantly decreased alveolar bone loss and serum MDA levels, no significant difference in their effectiveness was observed. Serum SOD levels were not significantly changed in all administered groups. P-value < 0.05.Conclusion In this study, both local injection and oral forms of Atorvastatin decreased inflammation and bone loss in periodontitis. However, no significant difference in their effectiveness was detected. However, local injection is superior to oral form due to effective lower dose

Histological Comparison of Effectiveness of Low Doses of Doxycyclineand Atorvastatin on gingival Inflammation and Alveolar Bone Loss in Experimental Model of Periodontitis in Rats

Objectives: The purpose of this study was to evaluate the effect of low dose doxycycline and atorvastatin on gingival inflammation and alveolar bone loss in an experimental model of periodontitis in rats.Methods: Forty male Sprague Dawley rats were divided into four study groups as follows: (I) experimental periodontitis control, (II) rats with periodontitis treated with low dose atorvastatin (10 mg/kg), (III) rats with periodontitis treated with low dose doxycycline (6 mg/kg) and rats with periodontitis treated with both doxycycline and atorvastatin. Periodontitis was induced by ligature placement around the upper left second molar foe seven days. The periodontitis group received saline, periodontitis/doxycycline group received doxycycline by oral gavage, periodontitis/atorvastatin group received atorvastatin by oral gavage and doxycycline/atorvastatin group received both drugs simultaneously (6 and 10 mg/kg, respectively) for 21 days after ligature placement. Then, the rats were sacrificed and their maxillae were removed, defleshed, and prepared for histopathological examination. Data were analyzed statistically by the Kruskal-Wallis test and Mann-Whitney U test at 5% level of significance and presented as frequencyResults: Using a combination of doxycycline and atorvastatin caused a significant decrease in gingival inflammation and alveolar bone loss (16.5%) and collagen degradation (13%) when compared to the control group (36.10% and 36.95%, respectively; P<0.001).Conclusion: Low dose atorvastatin and low dose doxycycline synergically prevented alveolar bone loss and collagen degradation in ligature-induced periodontitis in rats

Performance Evaluation of Medical Academic Libraries Based on DEA Approach

Medical academic libraries are required to exemplify and quantify the value of their services to their users and parent organizations. Using the Data Envelopment Approach (DEA) technique, this study reports and discusses the efficiency measurement of the 77 academic libraries in Type1 medical sciences universities in Iran. Eleven (11) input and outputs variables were selected to measure the efficiency and performance of the libraries. The selected variables were: Total volumes held, net volumes added during the research period, number of professional staff, and number of supporting staff (service, security, etc.). The total number of full-time students enrollment, full-time instructional faculties, total personal expenditures (professional and supporting staff), area of the libraries, library spaces, computers, and seating capacities. As representative variables of the services libraries provide to their users, we have selected as outputs opening hours per week, the number of registered readers/members (students, faculty, etc.), circulation transactions, and ‌the number of reader visits or attendance. The input-oriented BCC model analyzed libraries' efficiency and benchmarked each inefficient unit by determining and introducing similar efficient units in terms of services and multiple parameters. Out of the 77 libraries analyzed, 30 libraries were efficient, and 47 were ranked as inefficient. By addressing the performance details of each of the introduced units as a benchmark, the finding of this study can help the gatekeeper of these universities to plan and modify their library work plans to improve performance and achieve full efficiency.https://dorl.net/dor/20.1001.1.20088302.2022.20.2.16.1  

T he Use of Different Study Skills by Undergraduate and Postgraduate Students of Kerman Dental School

Background: Different study skills have been developed and introduced, although most learners are apparently unaware of them. Objectives: This study was conducted to investigate the frequency of using different study skills among undergraduate and postgraduate students. Method: The study population consisted of 201 undergraduate and 45 postgraduate students of Kerman Dental School in 2016-2017, who were selected using the random stratified sampling method. A questionnaire composed of four questions used to collect data. The questionnaire was a modified version of the one used by Karpiacke et al. The frequency of using different study skills (i.e., re-studying, re-writing, using flashcards, studying in groups, memorizing, teaching content, creating headings, self-testing, highlighting, finding connections, and finding real examples) was asked in the first question. Students’ preparation for exams and students’ satisfaction with their study skills were asked in the next questions. Data was analyzed using the chi-square test in SPSS23. Results: Of the 246 participants, 72 (35.8%) undergraduate students and 20 (44.4%) postgraduate students were male. The frequency of using different study skills was the same between the male and female undergraduate students, except for re-writing (P=0.024), studying in groups (P=0.018), and creating headings (P=0.018) which were higher in the female undergraduate students. However, there was no significant difference between male and female postgraduate students in terms of the frequency of using different study skills. Conclusion: The most and least commonly used strategies by the undergraduate and postgraduate students were re-studying and using flashcards, respectively. Only 30.3% of the undergraduate and 24.4% of the postgraduate students used the self-testing strategy. Keywords: Study skills, study strategies, students, dental schoo

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating enzyme that was shown to regulate cell proliferation, cell survival and inflammatory responses, mainly through inhibiting NF-κB signalling. Here we show that CYLD controls cell growth and division at the G1/S-phase as well as cytokinesis by associating with α-tubulin and microtubules through its CAP-Gly domains. Translocation of activated CYLD to the perinuclear region of the cell is achieved by an inhibitory interaction of CYLD with histone deacetylase-6 (HDAC6) leading to an increase in the levels of acetylated α-tubulin around the nucleus. This facilitates the interaction of CYLD with Bcl-3, leading to a significant delay in the G1-to-S-phase transition. Finally, CYLD also interacts with HDAC6 in the midbody where it regulates the rate of cytokinesis in a deubiquitinase-independent manner. Altogether these results identify a mechanism by which CYLD regulates cell proliferation at distinct cell-cycle phases

Lung contusion and cavitation with exudative plural effusion following extracorporeal shock wave lithotripsy in an adult: a case report

<p>Abstract</p> <p>Introduction</p> <p>Among the complications of extracorporeal shock wave lithotripsy are perinephric bleeding and hypertension.</p> <p>Case presentation</p> <p>We describe the case of a 31-year-old Asian man with an unusual case of hemoptysis and lung contusion and cavitation with exudative plural effusion due to pulmonary trauma following false positioning of extracorporeal shock wave lithotripsy. Differential diagnoses included pneumonia and pulmonary emboli, but these diagnoses were ruled out by the uniformly negative results of a lung perfusion scan, Doppler ultrasound, and culture of bronchoalveolar lavage and plural effusion, and because our patient showed spontaneous improvement.</p> <p>Conclusions</p> <p>False positioning of extracorporeal shock wave lithotripsy can cause lung trauma presenting as pulmonary contusion and cavitation with plural effusion.</p