Power and consent: Relation to self-reported sexual assault and acquaintance rape

College students think about and act differently with regards to power and consent in their relationships. The purpose of this study was to investigate how those attitudes and behaviors may relate to sexual assault and acquaintance rape. Power was examined at the intrapersonal, interpersonal, and socio-cultural levels. In addition, two perspectives on power were studied: power as dominating others and power as a sense of personal empowerment or control. A scale to measure this distinction was created. Three theories on the relation among power, consent, and sexual assault/rape were examined: (1) consent may moderate a relation between power and sexual assault/rape, (2) power and consent may exert individual effects on sexual assault/rape, and (3) power alone may have the most significant effects on sexual assault/rape. Generally, it was expected that participants who thought of power mainly as dominating others would be less concerned about consent in their relationships and more likely to report that they had or would sexually assault or rape. Two hundred seventy-six students (101 males, 175 females) provided information about their attitudes and behaviors involving power and consent, as well as information about sexual assault and rape proclivities and frequencies of self-reported sexual assault and rape perpetration and victimization. Results suggested that individual perspectives on power (the interpersonal level) may have the most relevance to sexual assault/rape behaviors. Participants whose thoughts and feelings about power were strongly oriented toward dominance but not toward personal empowerment were more likely to report having engaged in sexual assault/rape perpetration. Contrary to what was expected, consent did not appear to be related to either power or sexual assault/rape. Several theories for the lack of significance relating to consent and other forms of power are discussed. Findings suggest that more research should be done on the distinction between power as dominance and power as personal empowerment, particularly as this distinction pertains to sexual assault, acquaintance rape, and other forms of interpersonal violence

Fluid Accepting, Transporting, and Retaining Structure

The present invention provides a fluid accepting, transporting and retaining structure, useful in disposable absorbent articles. In-use fluid deposited on a disposable absorbent article employing such a structure is moved via interfiber and intrafiber transport to a fluid retention area remote from the point of fluid insult. By moving fluid away from the point of insult a more effective use of the absorbent core is achieved providing a clean and dry surface for the wearer

Source, character and weathering style of building stone in Culzean Castle & Country Park, Ayrshire

This report describes an assessment of the source, character and weathering style of the building stone that has been used in Culzean Castle and other historic structures that lie within Culzean Castle & Country Park (CCCP), in Ayrshire. The assessment was conducted by the Building Stones team of the British Geological Survey (BGS) on behalf of National Trust for Scotland (NTS). The project was funded by Historic Scotland, and the work has been conducted under the Memorandum of Agreement (2011-2016) between Historic Scotland and Natural Environment Research Council (NERC; as represented by BGS). The main building stone in CCCP structures is sandstone sourced locally from the Swanshaw Sandstone Formation. Descriptions of the quarries that are thought to have supplied the stone, and a brief assessment of the potential for obtaining new supplies of the same stone from these and other quarries, are presented in section 2 of this report. The results of a brief review of historical records of local quarrying activity and building history in CCCP are tabulated in an appendix and presented in section 3 as a ‘timeline’. The geological character of Swanshaw sandstone is described in section 4, and the main causes of weathering in sandstone are reviewed briefly in section 5. The character of weathering in the stonework of CCCP buildings, and some of the factors that are likely to be causing accelerated stone decay, are described in section 6. Recommendations for ‘best practice’ procedure in the long-term repair and maintenance of stonework in CCCP are presented in section 7. Key conclusions are summarised in section 8

Provenance of building stones in four 'galley castles' in Argyll

This report describes the outcomes of a project to assess the character and provenance of decorative stones in four ‘galley castles’ in Argyll. This includes a comparative investigation with a number of potential sources of sandstone and metamorphic rocks in Argyll and the surrounding region, which could have been quarried in the past

The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer

Background: Development of metastasis in breast cancer is a multi-step process comprising changes in cytoskeletal structure and gene expression of tumour cells leading to changes in cell adhesion and motility. The Rho GTPase proteins, which function as guanine nucleotide regulated binary switches, govern a variety of cellular processes including cell motility and migration, changes in cell adhesion as well as actin cytoskeletal reorganisation and gene expression/transcription. One group of activators which regulate the Rho-GTPases is the guanine nucleotide exchange factors (GEFs), and this study looked at three such GEFs, Trio, Vav1 and TIAM-1. The purpose of this study was to investigate the expression of these GEFs, in human breast cancer and assess the affect on clinical outcome. Methods: Specimens of fresh, frozen breast tumour tissue (n = 113) and normal background tissue (n = 30) were processed for quantitative PCR analysis. The expression and levels of expression of Trio, Vav1 and TIAM-1 were analysed using RT-PCR and real-time Q-PCR respectively. Sections were also immunostained with Trio and Tiam-1 antibodies. Results: Tumour tissue exhibited high levels of all three Rho activators Trio, Vav1 and TIAM-1 compared with normal background breast tissue, reaching a level of significance for the GEF Trio (p = 0.013). Trio levels also increased significantly in patients with a poor prognostic index (p = 0.04). Levels of TIAM-1 were significantly higher in tumour tissue from patients who died from breast cancer compared with those who survived (p = 0.04). No significant correlation was found between tumour grade and histology types. Conclusion: High expression levels of Trio, Vav1 and TIAM-1 were seen in breast tumours, especially in those with poor prognosis. This suggests that aberrant regulation of Rho family activities by GEFs may have an important prognostic value in breast cancer

Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome

Background The E-cadherin catenin system acts as an invasion suppressor of epithelial malignancies. However, it is debatable whether expression of E-cadherin or catenins is a useful prognostic marker in invasive breast cancer. Methods We measured the expression of E-cadherin and catenins (α-, β-, γ-catenin) in human breast carcinomas using real time quantitative polymerase chain reaction (Q-PCR) and investigated whether the expression levels were associated with known tumour variables or patient survival (median follow-up 72.2 months). RNA from frozen sections of breast tissue (tumour n = 124, background normal tissue n = 33) was reverse transcribed, quantified and analysed by Q-PCR with results expressed as number of copies of transcript/50 ng RNA. Results There was no statistically significant difference in the expression of E-cadherin and catenins (α-, β-, γ-catenin)in the 33 paired normal background and tumour tissues. The expression of E-cadherin, α-, β-, and γ-catenin in node positive tumours was similar to node-negative tumours. E-cadherin, α-, β-, and γ-catenin expression in breast tumours was not related to Nottingham Prognostic Index (NPI). There was no significant difference in the expression of E-cadherin, α-, β-, γ-catenin between the various TNM stages. None of the molecular markers significantly influenced survival. Lymph node status was the only significant predictor of survival. Conclusion Using real time quantitative PCR there was no difference in the expression of E-cadherin, α-, β-, γ-catenin between tumour and normal breast tissue. Furthermore, measurement of expression of these molecules was not of prognostic value in predicting long term outcome of women with breast cancer

New frontiers in healthcare environmental hygiene:thoughts from the 2022 healthcare cleaning forum

Healthcare environmental hygiene (HEH) has become recognized as being increasingly important for patient safety and the prevention of healthcare-associated infections. At the 2022 Healthcare Cleaning Forum at Interclean in Amsterdam, the academic lectures focused on a series of main areas of interest. These areas are indicative of some of the main trends and avenues for research in the coming years. Both industry and academia need to take steps to continue the momentum of HEH as we transition out of the acute phase of the Covid-19 pandemic. There is a need for new ways to facilitate collaboration between the academic and private sectors. The Clean Hospitals® network was presented in the context of the need for both cross-disciplinarity and evidence-based interventions in HEH. Governmental bodies have also become more involved in the field, and both the German DIN 13603 standard and the UK NHS Cleaning Standards were analyzed and compared. The challenge of environmental pathogens was explored through the example of how P. aeruginosa persists in the healthcare environment. New innovations in HEH were presented, from digitalization to tracking, and automated disinfection to antimicrobial surfaces. The need for sustainability in HEH was also explored, focusing on the burden of waste, the need for a circular economy, and trends towards increasingly local provision of goods and services. The continued focus on and expansion of these areas of HEH will result in safer patient care and contribute to better health systems