A retrospective multicentric observational study of trastuzumab emtansine in HER2 positive metastatic breast cancer: a real- world experience

We addressed trastuzumab emtansine (T-DM1) e cacy in HER2+ metastatic breast cancer patients treated in real-world practice, and its activity in pertuzumab- pretreated patients. We conducted a retrospective, observational study involving 23 cancer centres, and 250 patients. Survival data were analyzed by Kaplan Meier curves and log rank test. Factors testing signi cant in univariate analysis were tested in multivariate models. Median follow-up was 15 months and median T-DM1 treatment-length 4 months. Response rate was 41.6%, clinical bene t 60.9%. Median progression-free and median overall survival were 6 and 20 months, respectively. Overall, no di erences emerged by pertuzumab pretreatment, with median progression-free and median overall survival of 4 and 17 months in pertuzumab- pretreated (p=0.13), and 6 and 22 months in pertuzumab-naïve patients (p=0.27). Patients who received second-line T-DM1 had median progression-free and median overall survival of 3 and 12 months (p=0.0001) if pertuzumab-pretreated, and 8 and 26 months if pertuzumab-naïve (p=0.06). In contrast, in third-line and beyond, median progression-free and median overall survival were 16 and 18 months in pertuzumab- pretreated (p=0.05) and 6 and 17 months in pertuzumab-naïve patients (p=0.30). In multivariate analysis, lower ECOG performance status was associated with progression-free survival bene t (p<0.0001), while overall survival was positively a ected by lower ECOG PS (p<0.0001), absence of brain metastases (p 0.05), and clinical bene t (p<0.0001). Our results are comparable with those from randomized trials. Further studies are warranted to con rm and interpret our data on apparently lower T-DM1 e cacy when given as second-line treatment after pertuzumab, and on the optimal sequence order

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10&nbsp;years; 78.2% included were male with a median age of 37&nbsp;years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

The Value-Based Health Care model: A possible response to Covid-19 management

In recent days, due to the Covid-19 emergency, our health system has been called to respond to the strong pressure of the drastic increase in demand. Although the great efforts made by all the actors involved have reduced the dramatic impact of this emergency, the need for a profound restructuring of care and assistance services is now evident. Among the organizational models that address this need, Value-Based Health Care (VBHC) is among the most discussed. The determining factors for the success of the model are the alignment of all the stakeholders on a common goal, namely the value for the patient and the integration between the providers. There are many studies in the literature that focus on the ongoing transformation of the health systems of many countries into Value-Based systems, a clear picture does not yet emerge regarding the issues of implementation and the resulting benefits. Starting from the trend-starting articles on Value-Based Health Care, the work aims to create a theoretical framework through which to explain the advantages deriving from the application of the model compared to the current health emergency

La gestione della sindrome influenzale in Pediatria

Guidelines for the management of influenza in children were developed by the National Institutes for Health (Istituto Superiore di Sanit\ue0) together with all the major Italian paediatric societies. Rapid diagnostic tests are not recommended due to insufficient sensitivity and specificity. Etiological treatment with neuraminidase inhibitors or other antiviral agents is not recommended. Symptomatic treatment should be based on acetaminophen or ibuprofen. Antibiotics are not recommended unless fever persists for more than 7 days and signs of lower respiratory tract infection are present. Admission to hospital should be limited to cases with preexisting risk conditions, young infants with bronchiolitis, cases with respiratory distress and oxygen desaturation, or cases where home management is difficult due to social reasons

THE ORGANIZATIONAL DESIGN OF TECHNOLOGY TRANSFER OFFICES: DRAWING FROM AN ANALYSIS IN THE “FOOD VALLEY” OF PARMA

In today’s environments, both academics and practitioners recognise the importance of collaborations between university and industry, and thus of technology transfer activities in general. The extant literature highlights that different aspects can affect the outcome of such collaborations, among them the organisational design of technology transfer offices. Based on these premises, the aim of this paper is to map Parma University’s external relations in food science and technology-related disciplines and to uncover the nature of its knowledge exchanges and its collaborations network. This would shed some light about Parma University own entrepreneurial orientation and provide some organisational guidelines for the forthcoming TTO which is, at present, still in its “infancy” stage

Vegan Diet Health Benefits in Metabolic Syndrome

Plant-based diets (PBDs) are increasingly consumed by the Italian population and around the world. In particular, among PBDs, the vegan diet is a food pattern characterized by the exclusion of all animal-origin foods. What drives people to adopt this model are mainly ethical, health and environmental reasons. A vegan diet, if well-balanced and varied, can help in achieving and maintaining an optimal state of health. However, this nutritional approach, if not well-balanced, can cause deficiencies in proteins, omega-3 fatty acids, iron, vitamin D and calcium, zinc, iodine and, above all, vitamin B12. Oral food supplements especially fortified foods are recommended in these cases to restore the nutritional deficiencies. A vegan diet generally reduces the risk of developing chronic non-communicable degenerative diseases, such as metabolic syndrome (MetS) and, in addition, requires fewer natural resources for food production than an omnivorous diet. The aim of this review is to analyze the possible impact of the vegan diet on MetS onset and its treatment