Promoting equality through social inclusion: case studies from the European Social Charter

Promoting equality through social inclusion: case studies from the European Social Charte

Occupational health and safety in the UK : at a crossroads?

Occupational health and safety in the UK : at a crossroads

Davies et al. Supplementary material

Supplementary material - 7 supplementary tables, and 1 supplementary figure. Includes table of all genus level taxa and their CCM values, as well as extended species and genus level result

Assessing inhaled corticosteroid adherence and responsiveness in severe asthma using beclometasone dipropionate/formoterol NEXThaler™ dose-counting and nitric oxide monitoring

Background65% of people with severe asthma and a FeNO ≥45 ppb are non-adherent to inhaled corticosteroids (ICS). Digital devices recording both time-of-use and inhaler technique identify non-adherence and ICS responsiveness but are not widely available. As the NEXThaler™ dose counter only activates at an inspiratory flow of 35 L/min, this may provide an alternative to identifying ICS responsiveness.ObjectiveTo assess ICS adherence and responsiveness in severe asthma using beclometasone/formoterol (200/6 mcg) NEXThaler™ (BFN) dose-counting.MethodsSevere asthmatics with a FeNO ≥45 ppb were invited to use BFN in place of their usual ICS/long-acting β2-agonist (LABA). FeNO, ACQ6, lung function and blood eosinophil count were monitored for 3 months. A log10ΔFeNO ≥0.24 was used to define FeNO suppression as the primary marker of ICS responsiveness at day 28.Results27/48 (56%) patients demonstrated significant FeNO suppression at month 1 (median pre-114, post-48 ppb, pConclusionBFN dose counting identifies ICS responsiveness in severe asthma with the implication that these patients may not need to progress to biological therapies