Semi-Parametric Empirical Best Prediction for small area estimation of unemployment indicators

The Italian National Institute for Statistics regularly provides estimates of unemployment indicators using data from the Labor Force Survey. However, direct estimates of unemployment incidence cannot be released for Local Labor Market Areas. These are unplanned domains defined as clusters of municipalities; many are out-of-sample areas and the majority is characterized by a small sample size, which render direct estimates inadequate. The Empirical Best Predictor represents an appropriate, model-based, alternative. However, for non-Gaussian responses, its computation and the computation of the analytic approximation to its Mean Squared Error require the solution of (possibly) multiple integrals that, generally, have not a closed form. To solve the issue, Monte Carlo methods and parametric bootstrap are common choices, even though the computational burden is a non trivial task. In this paper, we propose a Semi-Parametric Empirical Best Predictor for a (possibly) non-linear mixed effect model by leaving the distribution of the area-specific random effects unspecified and estimating it from the observed data. This approach is known to lead to a discrete mixing distribution which helps avoid unverifiable parametric assumptions and heavy integral approximations. We also derive a second-order, bias-corrected, analytic approximation to the corresponding Mean Squared Error. Finite sample properties of the proposed approach are tested via a large scale simulation study. Furthermore, the proposal is applied to unit-level data from the 2012 Italian Labor Force Survey to estimate unemployment incidence for 611 Local Labor Market Areas using auxiliary information from administrative registers and the 2011 Census

Occurrence of <i>Philometra lateolabracis</i> (Nematoda: Philometridae) in the gonads of marine perciform fishes in the Mediterranean region

Gravid females of the nematode Philometra lateolabracis (Yamaguti, 1935), a parasite of gonads of marine perciform fishes, were found in wild and cultured dusky grouper Epinephelus marginatus (Lowe) from waters near the Balear Islands (Spain, Mediterranean Sea) and Sicily (Italy, Thyrrenean Sea), and in the greater amberjack Seriola dumerili (Risso) in Croatia (south-eastern Adriatic Sea). In wild E. marginatus in Spain, the overall prevalence was 21% and the intensity of infection 1 nematode per fish. The nematodes are briefly described and illustrated. The species Sanguinofilaria jordanoi López-Neyra, 1951, described from the ovary of Epinephelus gigas Brünich from Morocco, is synonymized with P. lateolabracis. This is the first documented record of P. lateolabracis from fishes of the Mediterranean region and its finding in S. dumerili represents a new host record. The possible importance of this pathogenic parasite for cultures of marine perciform fishes in the region is stressed

A new two-step synthesis of 2-alkylated 1, 4-diketones and α-alkylated γ-keto esters

2-Alkylated 1,4-diketones and a-alkylated g-keto esters can be easily prepared by a two-step procedure which involves first the conjugate addition of a nitroalkane to an enedione derivative in acetonitrile with DBU as base, followed by chemoselective hydrogenation of the C–C double bond (H2, 10% Pd/C) of the Michael adduct, obtained after elimination of nitrous acid.peer-reviewe

Sea Level Rise and Coastal Impacts. Innovation and Improvement of the Local Urban Plan for a Climate-Proof Adaptation Strategy

In recent years, the territorial impacts connected to sea level rise have prompted a reflection on the responsibilities of policy makers in transposing these issues into urban agendas. The need also emerged to both broaden and update the skills of urban planners and to improve territorial governance tools, with the aim of developing feasible regeneration and resilience strategies to face climate change. In this paper, a methodology for the production of Flood Risk Maps is presented, as applied to the Municipality of Ravenna, Italy, by only considering the static component of inundation hazard, i.e., the projected Mean Sea Level Rise, as a first step towards increased preparedness. The resulting Flood Risk Maps represent, in fact, an innovation with respect to the current cognitive framework that supports local urban planning, by providing information on a potential risk that has so far been overlooked. The method combines sea level rise projections under the pessimistic RCP8.5 scenario with georeferenced territorial data, aiming to identify the physical consistency of the urban-structure components which are potentially at risk. For successive time horizons (2030, 2050 and 2100), our results show the progressive impairment and potential degradation of extensive urban areas that are disregarded in the urban planning regulations currently in force. This preliminary evaluation phase is aimed at prompting and supporting the necessary updating of the planning tools and regulations adopted by the public bodies responsible for territorial governance, by identifying priority areas for intervention, and helping define mitigation and adaptation actions

Collaborative Semantic Tables

Abstract. The scenario defined by current Web architectures and paradigms (such as Cloud Computing), poses challenges and opportunities to users. On the one hand, they have to manage huge amounts of digital resources handled by different applications in spite of their possibly related content; on the other hand, they are enabled to share knowledge and participate to content creation. The interaction of these two aspects provided a great impulse to collaborative resource management: in this paper we present T++, an environment that ex-ploits semantic knowledge about digital resources in order to face these chal-lenges, by providing an integrated and smart management of heterogeneous in-formation objects

In vitro tolerance of Fusarium semitectum and Fusarium solani (anamorphic, Ascomycota) exposed to surface disinfectant commonly used in aquaculture

Se evaluó in vitro el efecto del: acido acético (AcH), ácido acético tamponado (AcH+AcNa), ioduro de potasio (IK) y Iodopovidona (IP) sobre la tasa de crecimiento (TC) de Fusarium solani (Mart.) Sacc. 1881 y Fusarium semitectum Berk. & Ravenel, 1875. Ambas especies fueron aisladas de ovas de Odontesthes bonariensis (Cuvier & Valenciennes, 1835). Las sustancias estudiadas son comúnmente utilizadas en acuicultura como desinfectantes de superficie. Las concentraciones ensayadas con actividad fungicida para ambas cepas fueron mucho más elevadas que las correspondientes concentraciones letales medias a 96 horas (CL50-96h) para ovas de pejerrey. Concentraciones inferiores a la CL50 - 96h exhibieron un efecto fungistático escaso o nulo.An in vitro evaluation of the antifungal effect of acetic acid (AcH), buffered acetic acid (AcH+AcNa), potassium iodide (KI) and Iodopovidone (IP); on the growth rate (GR) of Fusarium solani (Mart.) Sacc. 1881 and Fusarium semitectum Berk. & Ravenel, 1875 was performed. Both fungal species were isolated from eggs of the Argentinian silverside Odontesthes bonariensis (Cuvier & Valenciennes, 1835). The studied substances are commonly used in fish farming as surface disinfectants. The tested concentrations of this substances exhibited antifungal activity for both strains at concentrations higher than their 96h median lethal concentrations (LC50-96h) for the treated eggs; concentrations below the (LC50-96h) exhibited little or no effect.Fil: Pacheco Marino, Suani Giovanna. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo. Instituto de Botánica Spegazzini; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabello, Marta N.. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo. Instituto de Botánica Spegazzini; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Salibián, Alfredo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de Luján; Argentin

Primera liberación de juveniles de mero Epinephelus marginatus (Lowe, 1834) (Serranidae: Teleostei) cultivados en criadero en arrecifes artificiales en el mar Mediterráneo: resultados de un estudio experimental

A pilot experiment of stock enhancement based on the release of hatchery-reared juveniles of dusky grouper, Epinephelus marginatus, was carried out at two artificial reefs located 0.9 km offshore the south-western Sicilian coast (Central Mediterranean). The fish assemblages inhabiting the reefs were characterized using underwater visual census (UVC) surveys. Despite some differences in fish species richness, diversity and abundance, both artificial reefs provide suitable feeding resources and shelter opportunities for the settlement of dusky grouper juveniles. A total of 95 dusky grouper juveniles, which were 3 and 4 years old, were released. No stress-related effects on fish swimming or behaviour were observed during the step by step transportation to the sea-bottom at 20 m depth. After release, several groupers showed very low reactivity; freezing and schooling were the most common behaviours. The sighting rate after one month of UVC surveys was 15.7% and 20% at the two artificial reefs. No effect of fish size at release on grouper survival was observed. Some groupers were not recorded on the pyramid of release but elsewhere in the same artificial reef, which demonstrated their ability to move around the reef. The extent of dispersal of the released juveniles largely exceeded the area encompassed by the reefs, which was shown by recaptures of tagged groupers by local fishermen up to 13 km from the release site. This result provides a first insight into the potential of stock enhancement of hatchery reared dusky grouper juveniles for marine ranching and conservation purposes.Un experimento de repoblación, basado en la liberación de juveniles de mero Epinephelus marginatus cultivados en criadero, fue realizado en dos arrecifes artificiales situados 0.9 kilómetros fuera de las costas sicilianas sur-occidentales (Mediterráneo Central). La ictiofauna de los arrecifes fue caracterizada a través de inmersiones submarinas, utilizando la técnica de censo visual (UVC). A pesar de algunas diferencias en número de especies, diversidad y abundancia, ambos arrecifes artificiales proporcionaron recursos alimenticios y refugio adecuados para el establecimiento de juveniles de mero. En total se liberaron 95 meros juveniles de 3 y 4 años de edad. Ningún efecto relacionado al estrés fue observado en el comportamiento de natación de los peces durante el gradual transporte hasta 20 m de profundidad. Después de la liberación, varios meros mostraron una reactividad muy baja, siendo el comportamiento más común quedarse inmóviles y agregados. Después de un mes de censos visuales, las tasas de avistamientos obtenidas en los arrecifes artificiales fueron de 15.7% y 20%. No se observó relación entre el tamaño en el momento de la liberación y la supervivencia. Algunos peces no fueron observados cerca del punto de liberación sino en otra parte del mismo arrecife artificial, demostrando así su capacidad de moverse por los alrededores. Según lo indicado por los pescadores locales que recobraron meros marcados hasta 13 kilómetros del punto de liberación, el grado de la dispersión de los juveniles liberados superó ampliamente el área abarcada por los arrecifes. Este resultado proporcionan la primera evaluación del potencial de los juveniles de E. marginatus cultivados en criadero para actividades de cría en mar y conservación

Synergistic effect of plant compounds in combination with conventional antimicrobials against biofilm of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida spp

Bacterial and fungal biofilm has increased antibiotic resistance and plays an essential role in many persistent diseases. Biofilm-associated chronic infections are difficult to treat and reduce the efficacy of medical devices. This global problem has prompted extensive research to find alternative strategies to fight microbial chronic infections. Plant bioactive metabolites with antibiofilm activity are known to be potential resources to alleviate this problem. The phytochemical screening of some medicinal plants showed different active groups, such as stilbenes, tannins, alkaloids, terpenes, polyphenolics, flavonoids, lignans, quinones, and coumarins. Synergistic effects can be observed in the interaction between plant compounds and conventional drugs. This review analyses and summarises the current knowledge on the synergistic effects of plant metabolites in combination with conventional antimicrobials against biofilms of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The synergism of conventional antimicrobials with plant compounds can modify and inhibit the mechanisms of acquired resistance, reduce undesirable effects, and obtain an appropriate therapeutic effect at lower doses. A deeper knowledge of these combinations and of their possible antibiofilm targets is needed to develop next-generation novel antimicrobials and/or improve current antimicrobials to fight drug-resistant infections attributed to biofilm