5 research outputs found
Expanding DNA Sequence Recognition with Minor Groove Binders
- Author
- Publication venue
- Biophysical Society. Published by Elsevier Inc.
- Publication date
- 02/02/2011
- Field of study
Expanding DNA Sequence Recognition with Minor Groove Binders
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
A highly virulent variant of HIV-1 circulating in the Netherlands
- Author
- Aarsman K
- Abel Sylvie
- Abeler-Dörner Lucie
- Abgrall Sophie
- Abgueguen Pierre
- Abraham Bruno
- Ackens R P
- Adam Axel
- Adams A
- Agher Nouara
- Ahmad S
- Ainsworth J
- Aissi Emmanuelle
- Ajana FaĂŻza
- Al Moujahid A
- Alagna Laura
- Albers M
- Albert Jan
- Alberto A
- Alcaraz Isabelle
- Allavena Clotilde
- Allegre Thierry
- Allen S
- Allienne Christophe
- Alvarez Muriel
- Alvarez-Huve Sandrine
- Amirat Naouel
- Ammerlaan H S M
- Anderson J
- Andrady U
- Andre Marie
- Ang C W
- Antoniotti Odile
- Antonucci S
- Aquilina Christian
- Arastéh Keikawus
- Arbter Peter
- Arends J E
- Arumainayyagam J
- Arvieux CĂ©dric
- Aslan Alexandre
- Assi Assi
- Atoui Nadine
- Aubert V
- Audebert Franz
- Aumaitre Hugues
- Autar R S
- Avettand Fenoel VĂ©ronique
- Baas S
- Babiker Abdel
- Back N K T
- Baclet VĂ©ronique
- Baillat Vincent
- Bakker M
- Bakker Margreet
- Bakker Y
- Balausine Stéphanie
- Balsarin Florence
- Bannert Norbert
- Bannert Norbert
- Bansaal D
- Bantsimba Jonas
- Barbe Frédérique
- Barbuat Claudine
- Barin Francis
- Barth R E
- Bassant N
- Bastides Frédéric
- Batala Anne-Sophie
- Batard Marie-Laure
- Batisse Dominique
- Battegay M
- Baudry Thomas
- Baumgarten Axel
- Bax H I
- Bazin Christine
- Beck Charles
- Beck-Wirth GeneviĂšve
- Belan Alix Greder
- Belarbi Linda
- Bellenger Katharine
- Ben Abdallah Saadia
- Benomar Meryem
- Berger Jean-Luc
- Bergsma D
- Berkhout B
- Berkhout Ben
- Bermon N
- Bernard Louis
- Bernard Noëlle
- Bernard-Henry Claudine
- Bernasconi E
- Berrebi Valérie
- Berrevoets M A H
- Berthe Huguette
- Berzow Dirk
- Besnier Michel
- Bevan M
- Bevan Margaret-Ann
- Bezemer D O
- Bezemer Daniela
- Bezemer M
- Biekre Raphael
- Bieniek Bernhard
- Bierman W F W
- Biezunski Noemie
- Billaud Eric
- Blaauw H
- Blackman H
- Blackman Helen
- Blanc Arnaud
- Blanquart François
- Bloch Martine
- Blok W L
- Bodard LoĂŻc
- Bogner Johannes
- Bollens Diane
- Bolliot Claudine
- Bomers M
- Bonmarchand Manuela
- Bonnet Bénédicte
- Bonnet Fabrice
- Bonsall David
- Bont L J
- Boonstra A
- Bor P C J
- Bornarel Dominique
- Bottero Julie
- Bouchaud Olivier
- Boucher C A B
- Bouchez Sabelline
- Boue François
- Bourgeois Christine
- Boussard Jean-Luc
- Boutoille David
- Bouwhuis J W
- Bowman C
- Boyd A C
- Branger J
- Braun D L
- Brewer C
- Bridgwood A
- Brinkman K
- Brochier Corinne
- Brockmeyer Norbert
- Brokking W
- Brosseau Delphine
- Brouwer A E
- Brouwer A E
- Browing M
- Brunel-Dalmas Florence
- Brunet Cecile
- Bruns A H W
- Brétin N
- Bucher H C
- Buisson Marielle
- Buisson Martin
- Buiting A
- Buiting A G M
- Burger D
- Burgers K
- Burton-Jeangros C
- Bushby S
- Byrne P
- Böni J
- Cabie André
- Cabras Ornella
- Caby Fabienne
- Cahitte Isabelle
- Calderwood J
- Calin Ruxandra
- Calmy A
- Caltado Sabrina
- Campa Pauline
- Campbell L
- Cardon Fanny
- Care C
- Care Christine
- Carganico Andreas
- Carrick G
- Castel Philippe
- Cavassini M
- Cazanave Charles
- Cazenave Benoit
- Cents-Bosma A S
- Cerland Christophe
- Chabrol Amélie
- Chaigne de Lalande Severin
- Chaix Fabrice
- Chaix Marie-Laure
- Chambrin VĂ©ronique
- Champagne HĂ©lĂšne
- Chandramani S
- Chantalat Christelle
- Chapplain Jean-Marc
- Chardon Patricia
- Chas Julie
- Chavanet Pascal
- Cheneau Christine
- Chennebault Jean Marie
- Cheret Antoine
- Chevojon Pierre
- Chiarello Pierre
- Chirouze Catherine
- Christl Andreas
- Claas E C J
- Claassen M
- Clarke Mindy
- Claus Bernd
- Claus Jörg
- Clavel François
- Cloarec Nicolas
- Cohen Stuart J W T
- Colin de Verdiere Nathalie
- Collias Lio
- Connolly L
- Conort Guillaume
- Consigny Paul Henri
- Cordes Christiane
- Cordonnier François
- Cornavin Pauline
- Cornelissen M T E
- Cornelissen Marion
- Coupard MĂ©lissa
- Croisier Delphine
- Cros Agnes
- Cua Eric
- Curlier Elodie
- Currie J
- Cuzin Lise
- Daneluzzi Vincent
- Daniel Corinne
- Dauchy Frédéric
- David L
- Davido Benjamin
- Davids-Veldhuis S
- de Boer C
- de Boer M G J
- De Castro Nathalie
- de Cesare Mariateresa
- de Groot J
- de Groot L
- de Groot-de Jonge H
- de Haan M
- de Jong A
- de Jong-Peltenburg N C
- de Kroon I
- de Kruijf-van de Wiel B A F M
- de la Blanchardiere Arnaud
- de Mendonç A Melo M
- de Munnik E S
- de Regt M
- de Tejada B Martinez
- De Truchis Pierre
- de Vries-Sluijs T E M S
- de Weerd D A
- Dean G
- Debab Yasmine
- Debard Alexa
- Debast S B
- Dehn GĂŒnther
- Deiman B
- Delacroix Isabelle
- Delestan Mikael
- Delfraissy Jean François
- Delgado Jeannine
- Delllion Sophie
- Delobel Pierre
- Delpech Valerie
- Delsing C E
- den Hollander J G
- Denes Ăric
- Depond Audrey
- Derouineau Jean
- DeSouza C
- Detering-HĂŒbner Barbara
- Devendra S V
- Devidas Alain
- Diab Georges
- Diemer Myriam
- Dinh Aurélien
- Djoechro E
- Dofferhoff A S M
- Dollenmaier G
- Dondia Denis
- Donnelly C
- Donsesco RĂ©gine
- Dorama W
- Douma R A
- Drake S
- Drobacheff-Thiebaut Christine
- Ducroix Sophie
- Duffau Pierre
- Duijf-van de Ven C J H M
- Dulucq Marie Josée
- Dumont CĂ©cile
- Dunais Brigitte
- Duong Michel
- Dupke Stephan
- Dupont Matthieu
- Dupont Michel
- Duracinsky Martin
- Durant Jacques
- Durox HĂ©lĂšne
- Dutronc Hervé
- Duvivier Claudine
- Eden Aurélia
- Egger M
- El Berkaoui A
- El Moussaoui R
- Elharrar Brigitte
- Eliazevitch Murielle
- Ellerbroek P M
- Elsenburg L J M
- Elzi L
- Esnault Jean-Luc
- Essat Asma
- Esser Stefan
- Estreich S
- Evans M
- Faber S
- Fabre Isabelle
- Fairbrother Keith
- Fairley I
- Faucher Jean-François
- Faucher Olivia
- Faulkner S
- Faulkner Sue
- Faure Isabelle
- Faville R
- Faville Rebecca
- Fehr J
- Fellay J
- Fellay Jacques
- Fenske Stefan
- Feret Philippe
- Ferret Samuel
- Ferretti Luca
- Ferreyra Milagros
- Fialaire Pascale
- Fidler S
- Fidler S
- Fily Fabien
- Fischer Hugues
- Fischer Klaus
- Fischer Patricia
- Fitzgerald M
- Flegg P
- Foltzer Adeline
- Fonquernie Laurent
- Fox J
- Fox Julie
- Fraaij P L A
- Fraser Christophe
- Fraser P
- Freiwald Matthias
- Frietsch Bernhard
- Froguel Eric
- Fröschl Monika
- Furrer H
- Fux C A
- Gall Astrid
- Galle Peter
- Garipuy Daniel
- Garrait Valérie
- Gatey Caroline
- Gaud Catherine
- Gazaigne Sandrine
- Geelen S P M
- Geerders G F
- Geerlings S E
- Geffray LoĂŻk
- Gehring Peter
- Geilings J
- Gelinck L B S
- Gellen-Dautremer Justine
- Genet Claire
- Genet Philippe
- Gerard Laurence
- Gerbe Juliette
- Ghosn Jade
- Gibert Sylvie
- Gilleran G
- Gilquin Jacques
- Gilson R
- Gilson R
- Girard Jean-Jacques
- Girard Pierre-Marie
- Gisolf E H
- Glaunsinger Tobias
- Godin Collet Claire
- Godinot Mathieu
- Gohier Sandrine
- Goldberg David
- Golubchik Tanya
- Gomez M
- Gompels M
- Goorhuis A
- Goorney B
- Gorgievski M
- Goujard CĂ©cile
- Gourdon Florence
- Goussef Marie
- Grabowski M Kate
- Graefe Katrin
- Green P
- Green Pippa
- Green S
- Greenhough D
- Griffioen-van Santen B M G
- Grintjes-Huisman K J T
- Groeneveld P H P
- Grossi Olivier
- Groters M
- Guillevin LoĂŻc
- Guimard Thomas
- Gunsenheimer-Bartmeyer Barbara
- Gunsenheimer-Bartmeyer Barbara
- GĂŒler Cengiz
- GĂŒnthard H
- GĂŒnthard Huldrych F
- Hadacek Blanka
- Haerry D
- Haffner-Mauvais CĂ©cile
- Hage de Looff L
- Halaby T
- Hall Matthew
- Hall Nolwenn
- Halna Jean-Michel
- Hansen Stefan
- Harding J
- Haret Sophie
- Harindra V
- Hasse B
- Hassing R J
- Havenith T R A
- Hawkins D
- Hawkins David
- Hazenberg A
- Heikens E
- Heitmuller M
- Henriet S S V
- Herman S
- Herman Sandra
- Herpers B L
- Hertling Sandra
- Hessamfar Mojgan
- Higgs C
- Hillebregt M
- Hillenbrand Heribert
- Hintsche Bettina
- Hiraux Emmanuel
- Hirsch H H
- Hittinger Gilles
- Hoen Bruno
- Hoepelman A I M
- Hoffmann M
- Holtsema H
- Honore Patricia
- Hoogerwerf J
- Hoogewerf M
- Houlbert Dominique
- Hovius J W
- Howard L
- Hower Martin
- Hue Hervé
- Huleux Thomas
- Hustache Mathieu Mathieu
- HĂ€ussinger Dieter
- Hösli I
- Ingiliz Patrick
- Jacomet Christine
- Jacquet Jean Marc
- Jansen E R
- Jansen R
- Jansz A R
- Jayle Didier
- Jeantils Vincent
- Jebakumar S P R
- Jennings L
- Jerbi Saadia
- Jessen Arne
- Jessen Heiko
- Jeunet Noëlle
- Johnson Anne
- Johnson M
- Johnson Margaret
- Jolink H
- Jonges M
- Joulie Aline
- Jung Corinne
- Jurriaans S
- JĂ€ Gel-Guedes Eva
- JĂ€ger Hans
- Kahlert C
- Kaiser L
- Kampschreur L M
- Kansau Imad
- Karmochine Marina
- Katlama Christine
- Keelan-Phaf S
- Keiser O
- Kellam Paul
- Kellock D
- Kennedy N
- Kern Peter
- Keuter M
- Kirstetter Myriam
- KivelÀ Pia
- Klausen Gerd
- Kleene M J
- Kleinnijenhuis J
- Klimkait T
- Kloeze E
- Kmiec Isabelle
- Knapen M
- Knoester M
- Koffi Joseph
- Kok M
- Koopmans M P G
- Kootstra G J
- Kortmann W
- Kousignan Pascale
- Kouyos R
- Kouyos Roger D
- Kovari H
- Kowalczyk Jakub
- Kraan S
- Kreckel Peter
- Kreft Burkhard
- Kroon F P
- Kruijne E
- Kruiper M S M
- Ktorza Nadine
- Kuijpers T W
- Kuldanek K
- Kuldanek Kristin
- Kwa D
- Köppe Siegfried
- Laan L M
- Lacey H
- Lacoste Denis
- Laeyendecker Oliver
- Lafaurie Matthieu
- Lafeuillade Alain
- Lafon Erik
- Lagarrigue Myriam
- Lagneau Jean-Luc
- Lamaury Isabelle
- Lambregts M M C
- Lambry VĂ©ronique
- Lammers A J J
- Langebeek N
- Lanternier Fanny
- Lascaux Anne Sophie
- Lascoux-Combe Caroline
- Lauenroth-Mai Elke
- Launay Odile
- Lauw F N
- Lawlor V
- Le Puil SĂ©verine
- Lean C
- Leantez-Nainville Sophie
- Lechiche Catherine
- Lecuroux Camille
- Ledergerber B
- Lefebvre Benedicte
- Lefeuvre CĂ©line
- Lefort AgnĂšs
- Lelievre Jean Daniel
- Lelivelt K J
- Lemercier Yvon
- Lemoing Vincent
- Lempkes B
- Lenagat Sophie
- Leplatois Anne
- Leport Catherine
- Lepretre Annie
- Lerolle Nathalie
- Leroy Helene
- Lettinga K D
- Leureillard Didier
- Levy Yves
- Leyten E M S
- Livrozet Jean-Michel
- Loay D
- Lodewijk C
- Loeffen Y G T
- Lorenzen Thore
- Loulergue Pierre
- Louni Françoise
- Lowe S H
- Lucas E
- Luycx Odile
- Lyavanc Thomas
- Lynn W
- Machado Moise
- MacIntyre-Cockett George
- Magdy A
- Mahy Sophie
- Maignan Aline
- Majerholc Catherine
- Makhloufi Djamila
- Makinson Alain
- Malet Martine
- Malvy Denis
- Manceron VĂ©ronique
- Marigot Dhiba
- Markus Rudolf
- Marneef M
- Marquardt Ties
- Martell CĂ©dric
- Martha BenoĂźt
- Martin Anne
- Martin Isabelle Poizot
- Martinetti G
- Martinot Martin
- Marzolini C
- Masse Virginie
- Massip Patrice
- Mauboussin Jean-Marc
- May Thierry
- Mayr Christoph
- Mazhude C
- McCormack S
- McKernan S
- McKernan Sinead
- McLean K
- McLean Ken
- Meaden J
- Medus Marie
- Meijering R
- Meixenberger Karolin
- Melville R
- Mercie Patrick
- Merle Corinne
- Merlet Audrey
- Merrien Dominique
- Mette R
- Metzner K
- Meybeck AgnĂšs
- Meyer Andreas
- Meyer Laurence
- Meyer Laurence
- Mguni S
- Miailhes Patrick
- Michel Catherine
- Michelet Christian
- Middel A
- Minozzi Catherine
- Minton J
- Molina Jean-Michel
- Moll Arend
- Mollema F
- Moreau Philippe
- Morineau-Le Houssine Pascale
- Morlat Philippe
- Morris S
- Mortier Emmanuel
- Mouton-Rioux Virginie
- Moyes A
- Mudrikova T
- Mulder-Seeleman E
- Mullaney S
- Mullaney Scott
- Munier Anne-Lise
- Munjishvili L
- Murck J L
- Murphy C
- Murphy S
- Muthern Lisa
- MĂŒller Marcus
- MĂŒller N
- Nadal D
- Nait-Ighil Lella
- Naqvi Alissa
- Nastouli Eleni
- Natarajan U
- Nau Pascale
- Nauta N
- Neau Didier
- Nellen F J B
- Nellen J
- Neuville SĂ©golĂšne
- Niault Mathilde
- Nicca D
- Niesters H G M
- Nobel H
- Nouwen J L
- O'Mahony C
- Obadia Martine
- Ong E
- Ong Swee Hoe
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- Ouissa Rachida
- Paccalin François
- Pachart Anne
- Pailhes Sylvie
- Pajkrt D
- Paling F
- Pantaleo G
- Parcelier François
- Parrinello Maguy
- Partisani Maria
- Patey Olivier
- Patra-Delo SolĂšne
- Pavie Juliette
- Paz Pauline Caraux
- Peacock K
- Peeck B
- Pellegrin Jean-Luc
- Penot Pauline
- Peretti Delphine
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- Perrone VĂ©ronique
- Perry N
- Pertusa Marie-Carmen
- Peters E J G
- Petrov-Sanchez Ventzislava
- Peyramond Dominique
- Philip GisĂšle
- Phillips Andrew
- Phung Bao
- Pialoux Gilles
- Picard Odile
- Pichancourt Gilles
- Pichon François
- Pierre Isabelle
- Pierre-Francois Sandrine
- Pietri Marie-Pierre
- Pijnappel F J J
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- Pintado Claire
- Pinto Adriana
- Piroth Lionel
- Pistone Thierry
- Plettenberg Andreas
- Pogany K
- Poinsignon Yves
- Ponscarme Diane
- Pontesilli O
- Porte Lydie
- Porter Kholoud
- Post F
- Post Frank
- Postel Nils
- Posthouwer D
- Postma D F
- Pradier Christian
- Prevoteau du Clary François
- Priester MichĂšle
- Prins J M
- Pritchard J
- Pronk M J H
- Proust Aurélie
- Psomas Christina
- Quertainmont Yann
- Quinsat Denis
- Rabier Valérie
- Raffi François
- Rahamat-Langendoen J
- Raho-Moussa Mariem
- Rajamanoharan S
- Rajda N
- Rami Agathe
- Rangom Camille
- Rauch A
- Rausch Michael
- Ravaux Isabelle
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- Receveur Marie-Catherine
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- Regenass S
- Regtop R
- Rehaiem Sami
- Reimann Evelyne
- Reiss P
- Reiss Peter
- Reliquet VĂ©ronique
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- Reuter Stefan
- Reuwer A
- Revest Matthieu
- Rey David
- Reynes Jacques
- Ribeiro Emmanuel
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- Rozenbaum Willy
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- Saada Mathieu
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- Salmon Dominique
- Salzberger Bernd
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- Schaffert Andreas
- Scharnhorst V
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- Scheigrond A
- Scheper H
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- Schmalöer Dirk
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- Schnaitmann Eiko
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- Schranz Dietmar
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- Schubert Franz
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- Shoai-Tehrani Michka
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- Spornraft-Ragaller Petra
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- StĂŒndel Manfred
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- Sukthankar A
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- Touam Fatima
- Tourneur Muriel
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- Tredup JĂŒrgen
- Trein Andreas
- Trepo Christian
- Trkola A
- Truvedi M
- Tubiana Roland
- Tuijn E
- Turpault Isabelle
- Ulmer Albrecht
- Uludag AgnĂšs
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- Valette Michel
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- Vallois Dorothée
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- van Berkel M
- van Broekhuizen M C
- van Burgel N D
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- van den Akker M
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- van den Berk G E L
- van den Bersselaar D N J
- van der Bliek G L
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- van der Plas A
- van der Poll T
- van der Prijt L M M
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- van Duinen M
- van Eden J
- van Eeden A
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- Vareil Marc-Olivier
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- Verduyn-Lunel F
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- Vernazza P
- Viallard Jean-François
- Viard Jean-Paul
- Viget Nathalie
- Visser E
- Visser K M
- Vittecoq Daniel
- Voigt R
- Vriesde M
- Vrouenraets S M E
- Wagenvoort G H J
- Waldner Anne
- Wandolo Emily
- Wartel Guillaume
- Waters A
- Weber R
- Wegdam M C A
- Weijenberg-Maes B
- Weijsenfeld A M
- Weinberck Pierre
- Weiss Laurence
- Weitner Lutwin
- Wemmert Charlotte
- Wensing A M J
- Wesselmann Hans
- Wessels E
- White C
- White D
- Wicke Thomas
- Wiemer Dorothea
- Wiersinga W J
- Wijnands S
- Wildenbeest G S
- Wilding H
- Wilkins E
- Williams O
- Winter A
- Wintermans B
- Wirth Gaétane
- Wit F W M N
- Wither J
- Witte E C
- Wolfs T F W
- Wolthers K C
- Woodward R
- Woudstra T
- Wouthuyzen-Bakker M
- Wttewaal E
- Wymant Chris
- Yazdanpanah Yazdan
- Yerly S
- Young Carmel
- Young F
- Young S
- Youssef Elaney
- Zaaijer H L
- Zadeh Mahsa Mohseni
- Zaheri S
- Zak Dit Zbar Olivier
- Zeng Ai-Feng
- Zhao Lele
- Zucchetti Antonella
- Zucman David
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 04/02/2022
- Field of study
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
- Author
- Aceituno A
- Acosta I
- Adams A
- Adatia S
- Aerden Leo A.m.
- Aeron-thomas John
- Aggour Mohamed
- Aghaebrahim A
- Agid R
- Aguettaz Pierre
- Ahle Guido
- Aja L
- Akhtar N
- Al Najjar-carpentier Amen-adam
- Al'boutros S
- Al-ajlan F
- Albers Gregory W
- Albers Gregory W.
- Alexandrou M
- Alhazzaa M
- Ali L
- Allen E
- Almekhlafi M
- Alseraya A
- Aly J
- Amar Arun
- Amaro S
- Amato-marzialli B
- Amerson L
- Amiri H
- Andersen G
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- Ang Timothy
- Anton C
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- Apoil-brissard Marion
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- Ariño H
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- Arquizan Caroline
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- Attia John
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- Baillot Pierre-alexandre
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- Bakchine Serge
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- Baronnet-chauvet Flore
- Barral Francis-guy
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- Barros Renan Sales
- Bartolini Mario Bruno
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- Yavagal Dileep R.
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- Zerlauth Jean-baptiste
- Zimmel L
- Zuniga Paolo
- Zurasky J
- Publication venue
- 'Elsevier BV'
- Publication date
- 16/12/2017
- Field of study
Background:
General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods:
For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered.
Findings:
Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09â2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75â3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14â2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low.
Interpretation:
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
- Author
- A Aceituno
- A Adams
- A Aghaebrahim
- A Alseraya
- A Anderson
- A Azizi
- A Balgude
- A Bauer
- A Bharatha
- A Bhatt
- A Binder
- A Bitner
- A Blue-Schaller
- A Cayley
- A Cervera
- A Chamorro
- A Cullen
- A Dogan
- A Drofa
- A Ducruet
- A Ducruet
- A Durocher
- A DĂĄvalos
- A Farrag
- A Farrow-Schmidt
- A Flores
- A Fulton
- A Grande
- A Hassan
- A Hendrickson
- A Horev
- A Huberle
- A Hunter
- A Itreat
- A Jadhav
- A Jadhav
- A Jedlitschka
- A Kansara
- A Kastrup
- A Knox
- A KrĂŒtzelmann
- A Lima
- A LĂłpez
- A Malek
- A Malik
- A Manosalva
- A Martin
- A MartĂnez-Piñeiro
- A Minaeian
- A Mohammad
- A Moore
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- A Novak
- A O'Driscoll
- A O'Hare
- A Patel
- A Porter
- A Puri
- A Rai
- A Ranft
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- A Richmond
- A Ringlestein
- A Rohr
- A Rontal
- A Rontal
- A Rovira
- A Russman
- A Saad
- A Shuaib
- A Shuaib
- A Siddiqui
- A Sirelkhatim
- A Sirelkhatim
- A Swarnkar
- A Taqui
- A Tarabishy
- A Tomasello
- A Trivedi
- A Tunguturi
- A Wagner
- A Wakhloo
- A Weill
- A Weill
- A Witteler
- Aad van der Lugt
- Aad van der Lugt
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- Aditya Bharatha
- Adnan H. Siddiqui
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- M Charif
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- M Hamberger
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- M Hogan
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- M Kate
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- M Killer-Oberpfalzer
- M Kowarik
- M Lapierre
- M Lazzaro
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- O Imoukhuede
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- S Dehkharghani
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- S Subramaniam
- S Tateshima
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- Sabrina Debruxelles
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- Skye Coote
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- Stephen M Davis
- Susan Day
- Sylvain Lachaud
- Sylvie Godon-Hardy
- SĂ©bastien Richard
- SĂ©bastien Richard
- SĂ©verine Debiais
- T Boeckh-Behrens
- T Coughlan
- T Daly
- T Daly
- T Davis
- T Devlin
- T Devlin
- T Galvin
- T Harbo
- T Hendrickson
- T Hyldal
- T Jeerakathil
- T Kahles
- T Krings
- T Larson
- T Lowenkopf
- T Lynch
- T Marotta
- T Meindl
- T Musuka
- T Nguyen
- T Reiff
- T Roberts
- T Sajobi
- T Sajobi
- T Scheibe-Mirek
- T Stavngaard
- T Stewart
- T Stewart
- T Stewart
- T Walsh
- TA Yeo
- Tae-Hee Cho
- Tanya Frost
- TB Kotylak
- Teddy Y Wu
- TG Jovin
- Thanh Phan
- Theo Stijnen
- Thibaud Lebouvier
- Thierry Moulin
- Thomas J Oxley
- Thomas Liebig
- Thomas Ritzenthaler
- Thomas Ronziere
- Thompson Robinson
- Tiemen van Boxtel
- Timo Krings
- Timothy Ang
- Timothy J Harrington
- Timothy J Kleinig
- Tiphaine Rouaud
- Tissa Wijeratne
- Tobien H.C.M.L. Schreuder
- Tommy Andersson
- Tony Goddard
- TS Field
- Tudor G Jovin
- Tudor G. Jovin
- TW Watson
- U Grzyska
- V Biberacher
- V Chang
- V Costalat
- V Deshmukh
- V Dubuc
- V Kalugdan
- V Nambiar
- V Obach
- V Pandey
- V Patel
- V Reddy
- V Snyder
- V Szeder
- V Totoraitis
- V Totoraitis
- V Yang
- V Zegarac
- VA Coté
- Valérie Domigo
- Valérie Wolff
- Vasdev Ashok
- Vincent Cahagne
- Vincent Costalat
- Vincent Guiraud
- Violaine Rouaud Jaffrenou
- Vitor Mendes Pereira
- VK Reddy
- W Clark
- W Holloway
- W Maloney
- W Montanera
- W Morgan
- W Pfeilschifer
- W Poon
- W Tekle
- Wade Smith
- Werner Hacke
- WF Morrish
- WF Morrish
- Willem Jan J. van Rooij
- Willy Struijk
- Wilma Pellikaan
- Wim H van Zwam
- Wim H. van Zwam
- Winston Chong
- Wintermark
- WJ Hicks
- WJ Montanera
- WJ Montanera
- Wouter J Schonewille
- X Ayrignac
- X Urra
- Xavier Barreau
- Xavier Ducrocq
- Xavier Leclerc
- Y Deschaintre
- Y Li
- Y Yu
- Yannick Bejot
- YD Kim
- Yince Loh
- Yves Chau
- Yves Samson
- Yvo B W E M Roos
- Yvo B.W.E.M. Roos
- Z El-Zammar
- Z Khawaja
- Zofia Ross
- Zoltan Szatmary
- Zwenneke Flach
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