The possible role of anti-methicillin-resistant Staphylococcus aureus antimicrobial agents in spontaneous bacterial peritonitis

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SO045A NATIONWIDE SURVEY ON RADIATION RISK OF CANCER FROM MEDICAL IMAGING IN END STAGE KIDNEY DISEASE AND IN TRANSPLANT PATIENTS

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Probiotics-addicted low-protein diet for microbiota modulation in patients with advanced chronic kidney disease (ProLowCKD): A protocol of placebo-controlled randomized trial

Abstract Microbiota is a term coined to describe the population of bacteria, viruses and fungi that inhabit in symbiosis within a living host. A connection between unbalanced microbiota and chronic kidney disease has been established. In these patients, high levels of urea reach the intestine promoting the overgrowth of bacterial species that are prone to generate uremic toxins. Due to the high morbidity and mortality of this condition, a large number of therapeutic approaches to reduce inflammation and microbial uremic toxins have been proposed, with controversial results. A low protein diet, with a protein intake of 0.6–0.8 g/kg of body weight, is a useful and historically pursued option with this regard. The aim of our study is to evaluate, among patients with advanced renal failure not on dialysis, the synergic beneficial effects of this diet and the selected probiotics Bifidobacterium longum (mix DLBL) and Lactobacillus reuteri LRE02 (DSM 23878)

Efficiency of dispersive wave generation in dual concentric core microstructured fiber

We describe the generation of powerful dispersive waves that are observed when pumping a dual concentric core microstructured fiber by means of a sub-nanosecond laser emitting at the wavelength of~1064 nm. The presence of three zeros in the dispersion curve, their spectral separation from the pump wavelength, and the complex dynamics of solitons originated by the pump pulse break-up, all contribute to boost the amplitude of the dispersive wave on the long-wavelength side of the pump. The measured conversion efficiency towards the dispersive wave at 1548 nm is as high as 50%. Our experimental analysis of the output spectra is completed by the acquisition of the time delays of the different spectral components. Numerical simulations and an analytical perturbative analysis identify the central wavelength of the red-shifted pump solitons and the dispersion profile of the fiber as the key parameters for determining the efficiency of the dispersive wave generation process.Comment: 11 pages, 12 figure

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Multimodal nonlinear optical microscopy : from biophotonics to geophotonics

Nonlinear optical spectroscopies such as CARS and SRS offer rapid, label-free, chemical-specific imaging. And the ability to simultaneously deploy multiple modes of nonlinear imaging on a single sample is creating some striking new views of natural materials.Peer reviewed: YesNRC publication: Ye

New mode locking operation of a pulsed Nd:YAG laser by using atypical three wave interactions

International audienc

New Biomedical Opportunities Offered by Compact Sub-Nanosecond Supercontinuum Sources

International audienc

Pulsed supercontinuum source of variable pulse duration

La présente invention concerne une source supercontinuum apte à émettre des ondes entre le domaine infrarouge et le domaine ultraviolet