Motivating customers to develop and maintain a relationship with pharmacists: an application of a Stages of Change Model

A consistent branch of research in health communication has been focused on the study of the pharmacist - patient relationship. In past decades, the pharmacist and his role in the health care setting has shifted from a product oriented approach, where the primary focus was the production and compound of medicines, to a more patient oriented approach, with main focus becoming the understanding and caring for clients and the problems they bring to their health care providers. As a consequence, research in the health communication field, with a focus on community pharmacy settings needs to examine strategies to get the pharmacist closer to the clients, developing a long – term relationship, and adopting a more patient- oriented information approach to move closer to the needs of the client. The main purpose of my doctoral thesis is to examine the pharmacist - client relationship focusing in particular on the attempt to integrate the Stages of Change Model (Prochaska and DiClemente, 1983), with two models currently in use to describe relationship development in the pharmacy context, in order to identify strategies that can support the pharmacists in building a relationship of loyalty with their clients in the future. I hypothesized that targeting health information according to the level of the relationship clients are in could produce the necessary loyalty to commit to the pharmacist and to enhance the long run acceptance and effectiveness of the health message. In particular, the empirical section is devoted to understanding how to produce the necessary loyalty that can lead to better future response for the therapeutic and health needs of the client. The hypothesis was tested in the context of Tessin pharmacist – client relationship by means of a three phase study: an explorative study, a descriptive study, and finally an intervention study. Using the data collected in the descriptive study, two models of relationship development were tested: one static and one dynamic. The static model treats the perceived relational benefits, relationship selling behaviours, perceived expertise and stages of change constructs as antecedents of trust. The dynamic model adds the Stages of Change moderating effect on perceived benefits, perceived expertise, perceived relationship selling behaviours, as antecedents of trust. In the dynamic model, trust is directly influenced by the perceived expertise of the pharmacist, relationship selling behaviours, and perceived relational benefits. The Stages of Change Model moderated the relationship between perceived relational benefits and trust, and approached significance in moderating the relationship between perceived expertise and trust. The moderated relationship influences the way to structure an intervention to increase client intention to frequent the pharmacy in the future: in particular, it suggests tailoring the message depending on the stage of the relationship. The analysis of the data shows that targeting health messages according to the level of client relationship (developmental stage/maintenance stage) and building the messages focusing on the variables most influential to the particular relationship stage should bring to a more “loyal client” in the future. Furthermore, results in the intervention study show that for people in the developmental stage, a targeted message, that is a message focused on relational benefits, was more effective than either no message, or a stage mismatched message

Witnessing entanglement in hybrid systems

We extend the definition of entanglement witnesses based on structure factors to the case in which the position of the scatterers is quantized. This allows us to study entanglement detection in hybrid systems. We provide several examples that show how these extra degrees of freedom affect the detection of entanglement by directly contributing to the measurement statistics. We specialize the proposed witness operators for a chain of trapped ions. Within this framework, we show how the collective vibronic state of the chain can act as an undesired quantum environment and how ions quantum motion can affect the entanglement detection. Finally, we investigate some specific cases where the method proposed leads to detection of hybrid entanglement.Comment: 6 pages, 4 figure

Detecting Non-Markovianity of Quantum Evolution via Spectra of Dynamical Maps

We provide an analysis on non-Markovian quantum evolution based on the spectral properties of dynamical maps. We introduce the dynamical analog of entanglement witness to detect non-Markovianity and we illustrate its behavior with several instructive examples. It is shown that for several important classes of dynamical maps the corresponding evolution of singular values and/or eigenvalues of the map provides a simple non-Markovianity witness

Efficient superdense coding in the presence of non-Markovian noise

Many quantum information tasks rely on entanglement, which is used as a resource, for example, to enable efficient and secure communication. Typically, noise, accompanied by loss of entanglement, reduces the efficiency of quantum protocols. We develop and demonstrate experimentally a superdense coding scheme with noise, where the decrease of entanglement in Alice's encoding state does not reduce the efficiency of the information transmission. Having almost fully dephased classical two-photon polarization state at the time of encoding with concurrence $0.163\pm0.007$, we reach values of mutual information close to $1.52\pm 0.02$ ($1.89\pm 0.05$) with 3-state (4-state) encoding. This high efficiency relies both on non-Markovian features, that Bob exploits just before his Bell-state measurement, and on very high visibility ($99.6\%\pm0.1\%$) of the Hong-Ou-Mandel interference within the experimental set-up. Our proof-of-principle results with measurements on mutual information pave the way for exploiting non-Markovianity to improve the efficiency and security of quantum information processing tasks.Comment: 6 pages, 4 figures. V2: Minor change

Nonequilibrium quantum thermodynamics in Coulomb crystals

We present an in-depth study of the nonequilibrium statistics of the irreversible work produced during sudden quenches in proximity to the structural linear-zigzag transition of ion Coulomb crystals in 1+1 dimensions. By employing both an analytical approach based on a harmonic expansion and numerical simulations, we show the divergence of the average irreversible work in proximity to the transition. We show that the nonanalytic behavior of the work fluctuations can be characterized in terms of the critical exponents of the quantum Ising chain. Due to the technological advancements in trapped-ion experiments, our results can be readily verified

Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, beta-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma

Background: Osteosarcoma (OSA) represents the most common canine primary bone tumour. Despite several pathways have been investigated so far, few molecules have been identified as prognostic tools or potential therapeutic targets, and there is still the need to find out molecular pathways with specific influence over OSA progression to facilitate earlier prognosis and treatment.Aims of the present study were to evaluate the immunohistochemical pattern and levels of expression of a panel of molecules (survivin, β-catenin, caspase 3 -inactive and active forms- and p53) involved in cell cycle and apoptosis regulation in canine OSA samples, known to be of interest in the study also of human OSA, and to detect specific relations among them and with histological tumour grade, disease free interval (DFI) and overall survival (OS).Results: Nuclear β-catenin immunostaining was detected in normal osteoblasts adjacent to the tumour, and in 47% of the cases. Cytoplasmic and/or membranous immunostaining were also observed. Nuclear survivin and p53 positive cells were found in all cases. Moderate/high cytoplasmic β-catenin expression (≥10% positive cells) was significantly associated with the development of metastasis (P = 0.014); moderate/high nuclear p53 expression (≥10% positive cells) was significantly associated with moderate/high histological grade (P = 0.017) and shorter OS (P = 0.049). Moderate/high nuclear survivin expression (≥15% positive cells) showed a tendency toward a longer OS (P = 0,088).Conclusions: The present results confirmed p53 as negative prognostic marker, while suggested survivin as a potential positive prognostic indicator, rather than indicative of a poor prognosis. The detection of nuclear β-catenin immunostaining in normal osteoblasts and the absent/low expression in most of the OSAs, suggested that this pathway could not play a major role in oncogenic transformation of canine osteoblasts. Further studies are needed to confirm these hypotheses

Robust non-Markovianity in ultracold gases

We study the effect of thermal fluctuations on a probe qubit interacting with a Bose-Einstein condensed (BEC) reservoir. The zero-temperature case was studied in [Haikka P et al 2011 Phys. Rev. A 84 031602], where we proposed a method to probe the effects of dimensionality and scattering length of a BEC based on its behavior as an environment. Here we show that the sensitivity of the probe qubit is remarkably robust against thermal noise. We give an intuitive explanation for the thermal resilience, showing that it is due to the unique choice of the probe qubit architecture of our model.Comment: Submitted to FQMT11 topical issue of the Physica Script