MiR-141 not only modulates anoikis resistance of ovarian cancer cells but also alters pre-metastatic niche for ovarian cancer cell metastatic colonization

Conference Theme: From Cancer Biology to the ClinicINTRODUCTION: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide. This disease is generally called the ‘silent killer’ because there are no symptoms and thus, the majority of patients are found in advanced stages accompanied by extensive metastasis. Most deaths from this cancer are attributed to metastatic progression. The cancer metastasis is determined by the priming of metastatic niche and the intrinsic properties of cancer cells to adapt ...postprin

Is antenatal antibody screening worthwhile in Chinese?

A total of 1997 pregnant women were screened during their first antenatal visit for irregular antibodies for the prevention of haemolytic disease of the newborn. Patient sera were tested against a panel of group 0 screen cells including one with the expression of Miltenberger determinants GP.Mur, 17 women (0.85%) had irregular antibodies of which four were of potential clinical significance, including one with anti-D, two with anti-E and one with anti-D, anti-E and anti-G. Although antenatal antibody screening is mandatory in Western populations, our results suggest that this may not be necessary in the Chinese population except for those who are Rh D-negative or who have a history of haemolytic disease of the newborn.link_to_subscribed_fulltex

The role of heme oxygenase-1 in the protection of chronic intermittent hypoxia-induced lung injury in vivo

目的 观察慢性间歇低氧(CIH)对大鼠肺脏局部炎症反应以及肺泡结构的影响,探讨药物诱导血红素加氧酶-1(HO-1)在此过程中的干预效果.方法 Sprague-Dawley雄性大鼠24只,按随机数字表法分为常氧对照组、CIH组、常氧+hemin干预组(hemin组)和CIH+hemin干预组(CIH+ hemin组),每组6只.CIH组大鼠予间歇低氧环境中(4 min10％ +2 min21％ 02,8 h/d,共6周),对照组大鼠置于常氧环境中.利用腹腔注射hemin(4 mg/kg)诱导HO-1表达,IN组及CIH组腹腔注射等体积生理盐水.采用western blot检测大鼠肺脏HO-1及cleaved caspase3表达水平,ELISA检测大鼠肺脏局部炎症因子中性粒细胞化学趋化因子-1(CINC-1)、IL-6、肿瘤坏死因子-α(TNF-α)和单核细胞趋化蛋白-1(MCP-1)的表达水平,使用HE染色观察大鼠肺脏病理改变.结果 为期6周的CIH可明显升高肺脏炎症因子TNF-α[(2.20 ±0.10) vs (1.80±0.08) ng/ml]、IL-6[(0.87 ±0.05) vs(0.52 ±0.05) ng/ml]、CINC-1[(66 ±6) vs (39 ±5) pg/ml]和MCP-1[(2.20土0.09)vs(1.40±0.10) ng/ml]以及cleaved caspase3表达(均P＜0.05),hemin可明显抑制由于CIH诱导的肺脏炎症因子[(TNF-α:(1.60±0.20) ng/ml,IL-6:(0.60±0.07) ng/ml,CINC-1:(45±6) pg/ml,MCP-1:(1.80 ±0.10) ng/ml,均P＜0.05]水平增高以及cleaved caspase3表达(P＜0.01),肺脏HO-1表达明显升高.hemin可进一步增加CIH下肺脏HO-1的表达水平.CIH导致肺泡结构损伤,而hemin诱导的HO-1升高可明显抑制由于CIH诱导的肺脏病理改变.结论 CIH可导致肺脏局部炎症因子表达升高,细胞凋亡及肺泡结构破坏,药物诱导HO-1升高可抑制CIH诱导的局部炎症反应和细胞凋亡,逆转肺泡结构损伤,表明CIH对肺脏的损伤作用及HO-1的保护功能

Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines: A self-controlled case series study

BACKGROUND & AIMS: Case reports of severe acute liver injury (ALI) following COVID-19 vaccination have recently been published. We evaluated the risks of ALI following COVID-19 vaccination (BNT162b2 or CoronaVac). METHODS: We conducted a modified self-controlled case series analysis using the vaccination records in Hong Kong with data linkage to electronic medical records from a territory-wide healthcare database. Incidence rate ratios (IRRs) for ALI outcome in the 56-day period following first and second doses of COVID-19 vaccines in comparison to the non-exposure period were estimated and compared to the ALI risk in patients with SARS-CoV-2 infection. RESULTS: Among 2,343,288 COVID-19 vaccine recipients who were at risk, 4,677 patients developed ALI for the first time between 23rd February 2021 to 30th September 2021. The number of ALI cases within 56 days after the first and second dose of vaccination were 307 and 521 (335 and 334 per 100,000 person-years) for BNT162b2, and 304 and 474 (358 and 403 per 100,000 person-years) for CoronaVac, respectively, compared to 32,997 ALI cases per 100,000 person-years among patients within 56 days of SARS-CoV-2 infection. Compared to the non-exposure period, no increased risk was observed in the 56-day risk period for first (IRR 0.800; 95% CI 0.680–0.942) and second (IRR 0.944; 95% CI 0.816–1.091) dose of BNT162b2, or first (IRR 0.689; 95% CI 0.588–0.807) and second (IRR 0.905; 95% CI 0.781–1.048) dose of CoronaVac. There were no severe or fatal cases of ALI following COVID-19 vaccination. CONCLUSION: There was no evidence of an increased risk of ALI associated with BNT162b2 or CoronaVac vaccination. Based on all current available evidence from previous studies and our study, the benefit of mass vaccination far outweighs the ALI risk from vaccination

Brain-Controlled Wheelchair Through Discrimination of Two Mental Tasks

Recently, Brain-Computer Interface (BCI) research has been targeted at the rehabilitation of motor-disabled individuals because it helps to establish a communication and control channel for them. This new channel could be used to restore motor functions or to provide them with mobility using a BCI controlled motorized wheelchair. One of the most important limitations of these systems is to guarantee that a person can, through his mental activity, safely control the variety of navigation commands that provide control of the wheelchair: advance, turn, move back, and stop. The vast majority of the mobile robot navigation applications that are controlled via a BCI demand that the user performs as many different mental tasks as there are different control commands. Having a higher number of commands makes it easier for the subjects to navigate through the environment, since they have more choices to move. However, despite this is an intuitive solution, the classification accuracy of such systems gets worse as the number of mental tasks to identify increases. Some studies proved that the best classification accuracy is achieved when only two classes are discriminated. In order to enable an effective and autonomous wheelchair navigation with a BCI system without worsening user performance, our group proposed and later developed a new paradigm based on the discrimination of only two classes (one active mental task versus any other mental activity), which enabled the selection of four commands, besides the stop command: move forwards, turn right, move backward and turn left. In the present study, a subject participated in an experiment in order to freely control a wheelchair carrying out continuous movements. The obtained results suggest that the proposed BCI system seems to be an effective way of driving a robotic wheelchair autonomously.This work was partially supported by the University of Málaga, by the Spanish Ministry of Economy and Competitiveness through the projects LICOM (DPI2015-67064-R) and INCADI (TEC 2011-26395), and by the European Regional Development Fund (ERDF).2018-12-3

Authoritative parenting of Chinese mothers of children with and without intellectual disability

The present study examined authoritative parenting and associations with parenting sense of competence and social support in Chinese mothers of children with intellectual disability and mothers of typically developing children. One hundred and sixty-seven mothers of children with intellectual disability with a mean age of 10.89 years (SD = 1.74) and 119 mothers of typically developing children with a mean age of 10.55 years (SD = 1.10) participated in a survey. Mothers of children with intellectual disability reported similar levels of parental warmth, and less use of reasoning and autonomy support compared with mothers of typically developing children. Parenting efficacy contributed uniquely to three dimensions of authoritative parenting for mothers of children with intellectual disability. By comparison, parenting efficacy did not contribute to use of reasoning and autonomy support for mothers of typically developing children. Social support made a unique but small contribution to parental warmth but not to parental reasoning and autonomy support for mothers of children with intellectual disability. For mothers of typically developing children, social support was associated with both parental warmth and autonomy support. This study suggests that child disability status is related to maternal authoritative parenting, and additionally, parenting efficacy plays a more critical role in predicting authoritative parenting of Chinese mothers of children with intellectual disability than mothers of typically developing children