Using the transit of Venus to probe the upper planetary atmosphere

The atmosphere of a transiting planet shields the stellar radiation providing us with a powerful method to estimate its size and density. In particular, because of their high ionization energy, atoms with high atomic number (Z) absorb short-wavelength radiation in the upper atmosphere, undetectable with observations in visible light. One implication is that the planet should appear larger during a primary transit observed in high energy bands than in the optical band. The last Venus transit in 2012 offered a unique opportunity to study this effect. The transit has been monitored by solar space observations from Hinode and Solar Dynamics Observatory (SDO). We measure the radius of Venus during the transit in three different bands with subpixel accuracy: optical (4500A), UV (1600A, 1700A), Extreme UltraViolet (EUV, 171-335A) and soft X-rays (about 10A). We find that, while the Venus optical radius is about 80 km larger than the solid body radius (the expected opacity mainly due to clouds and haze), the radius increases further by more than 70 km in the EUV and soft X-rays. These measurements mark the densest ion layers of Venus' ionosphere, providing information about the column density of CO2 and CO. They are useful for planning missions in situ to estimate the dynamical pressure from the environment, and can be employed as a benchmark case for observations with future missions, such as the ESA Athena, which will be sensitive enough to detect transits of exoplanets in high-energy bands.Comment: 13 pages, 2 figures; published in Nature Communications; the full and copy-edited version is open access at http://www.nature.com/ncomms/2015/150623/ncomms8563/full/ncomms8563.htm

Chemometric study of the excipients’ influence on polymorphic-behavior: Mefenamic acid as case of study

The assessment of polymorphism is a problematical issue for regulatory agencies, because variations among crystalline forms of active pharmaceutical ingredient (API) can lead to changes in the efficacy and safety of formulated product. Such conversions are very hard to be detected, thus, the development of techniques for the identification, characterization and quantification of polymorphs results essential in all stages of the manufacturing process. The presence of excipients in formulated products may change the crystal stability of an API, by catalyzing a polymorphic transformation or stabilizing the less stable form. As paradox, all suitable analytical techniques (spectroscopies, thermal analysis, NMR and DRX, and others) for polymorphic analysis are affected by excipients. A deep understanding of the polymorphism-excipient relationship is in full accordance with Quality by Design (QbD) paradigm, the systematic approach focused in quality building into a product based in the full understanding of the products and process. In this work, a novel approach based on thermal stress, MIR monitoring, multivariate curve resolution with alternating least squares (MCR-ALS) and kinetic analysis was developed and applied to monitor polymorphism behavior of model API in formulated products. Commercial tablets, physical mixtures and commercial API, were processed and analyzed under the proposed approach. Commercial tablets of MFA revealed a fast conversion to Form II, contrasting to the behavior of the pure API. Physical mixtures showed similar behavior to commercial tablets, thus reduction in transformation times was related to MFA-excipients physical interaction, even at surface level. Calorimetric studies support the conclusion obtained. The developed approach could be extended to others APIs and other stress sources (humidity, solvents, mechanical forces and its combinations), being a valuable tool for QbD environment.Fil: Antonio, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Calvo, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Maggio, Ruben Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentin

Evaluation of Fitness and the Balance Levels of Children with a Diagnosis of Juvenile Idiopathic Arthritis: A Pilot Study

Background: Juvenile idiopathic arthritis is a main cause of physical disability and has high economic costs for society. The purpose of this study was to assess the fitness levels and the postural and balance deficits with a specific test battery. Methods: Fifty-six subjects were enrolled in this study. Thirty-nine healthy subjects were included in the control group and seventeen in the juvenile idiopathic arthritis group. All subjects were evaluated using a posturography system. The fitness level was evaluated with a battery of tests (Abalakov test, sit-up test, hand grip test, backsaver sit and reach, the toe touch test). An unpaired t-test was used to determine differences. Pearson's correlation coefficient was used to evaluate the correlation between the tests. Results: The battery of tests demonstrated that subjects in the juvenile idiopathic arthritis group have lower fitness levels compared to the control group. The juvenile idiopathic arthritis group showed low postural control with respect to the control group. Pearson analysis of the juvenile idiopathic arthritis group data showed significant correlations between variables. Pearson's results from the control group data showed a similar trend. Conclusions: The results suggest that the battery of tests used could be an appropriate tool. However, we highlight that these conclusions need to be supported by other studies with a larger population scale

On Stellar Coronae and Solar Active Regions

Based on Yohkoh Soft X-Ray Telescope (SXT) observations of the Sun near peak activity level obtained on 1992 January 6, we search for coronal structures that have emission measure distributions EM(T ) that match the observed stellar coronal emission measure distributions derived for the intermediate-activity stars v Eri (K2 V) and m Boo A (G8 V) from Extreme Ultraviolet Explorer spectro- scopic observations. We —nd that the temperatures of the peaks of the observed stellar distributions EM(T ), as well as their slopes in the temperature range are very similar to those 6.0 ( log T ( 6.5, obtained for the brightest of the solar active regions in the 1992 January 6 SXT images. The observed slopes correspond approximately to EM P T b with b D 4, which is much steeper than predicted by static, uniformly heated loop models. Plasma densities in the coronae of v Eri and m Boo A are also observed to be essentially the same as the plasma densities typical of solar active regions. These data provide the best observational support yet obtained for the hypothesis that solar-like stars up to the activity levels of v Eri (K2 V) and m Boo A are dominated by active regions similar to, though possibly considerably larger than, those observed on the Sun. The surface —lling factor of bright active regions needed to explain the observed stellar emission measures is approximately unity. We speculate on the scenario in which small-scale ii nano—ares ˇˇ dominate the heating of active regions up to activity levels similar to those of v Eri (K2 V) and m Boo A. At higher activity levels still, the interactions of the active regions themselves may lead to increasing —aring on larger scales that is responsible for heating plasma to the observed coronal temperatures of on very active stars. Observations of X-ray and T Z 107 K EUV light curves using more sensitive instruments than are currently available, together with determi- nations of plasma densities over the full range of coronal temperatures (106¨107 K and higher), will be important to con—rm —are heating hypotheses and to elicit further details concerning coronal structures at solar-like active region temperatures and the temperatures that characterize the most (T ( 5 ) 106 K) active stars (T Z 107 K). Subject headings: stars: coronaestars: individual (v Eridani, m Bootis) ¨ Sun: corona ¨ Sun: X-rays, gamma raysX-rays: star

School-age vaccination, school openings and Covid-19 diffusion

This article investigates the relationship between school openings and Covid-19 diffusion when school-age vaccination becomes available. The analysis relies on a unique geo-referenced high frequency database on age of vaccination, Covid-19 cases and hospitalization indicators from the Italian region of Sicily. The study focuses on the change of Covid-19 diffusion after school opening in a homogeneous geographical territory (i.e., with the same control measures and surveillance systems, centrally coordinated by the Regional Government). The identification of causal effects derives from a comparison of the change in cases before and after school opening in the school year 2020/21, when vaccination was not available, and in 2021/22, when the vaccination campaign targeted individuals of age 12-19 and above 19. Results indicate that, while school opening determined an increase in the growth rate of Covid-19 cases in 2020/2021, this effect has been substantially reduced by school-age vaccination in 2021/2022. In particular, we find that an increase of approximately 10% in the vaccination rate of school-age population reduces the growth rate of Covid-19 cases after school opening by approximately 1%

High Pressure Assisted Coronary Stent Implantation Accomplished Without Intravascular Ultrasound Guidance and Subsequent Anticoagulation

AbstractObjectives. The purpose of this study was to determine the efficacy of treatment with antiplatelet therapy and no anticoagulation after high pressure assisted coronary stent implantation performed without intravascular ultrasound (IVUS) guidance.Background. Previous studies have shown that during IVUS-guided Palmaz-Schatz coronary stenting, it is safe to withhold anticoagulation when stent expansion has been optimized by high pressure balloon dilation.Methods. Patients that had successful coronary stenting without IVUS guidance were treated with ticlopidine, 500 mg/day, and aspirin, 325 mg/day, for 1 month and then received only aspirin, 325 mg/day, indefinitely. Patients were not treated with warfarin (Coumadin) or heparin after successful stenting. Clinical and angiographic events were assessed at 1 month.Results. A total of 201 intracoronary stents were implanted in 127 patients with 137 lesions. The average number of stents per lesion was 1.4 ± 0.8, and the average number of stents per patient was 1.6 ± 1.1. Stent deployment was performed for elective indications in 79% of procedures and for emergency indications in 21%. There were four stent thrombosis events for a per patient event rate of 3.1% and a per lesion event rate of 2.9%.Conclusions. After high pressure assisted stenting performed without IVUS guidance, there was an acceptable incidence of 3.1% of stent thrombosis with the combination of short-term ticlopidine and aspirin therapy and no anticoagulation. Although the study involved only 127 patients, the results support the relative safety of stenting without IVUS guidance and with antiplatelet therapy only in comparison to historical trials on stenting performed with postprocedure anticoagulation.(J Am Coll Cardiol 1977;29:21–7)

Signatures of X-ray dominated chemistry in the spectra of exoplanetary atmospheres

High-energy radiation from stars impacts planetary atmospheres deeply affecting their chemistry, providing departures from chemical equilibrium. While the upper atmospheric layers are dominated by ionizations induced by extreme ultraviolet radiation, deeper into the atmosphere molecular abundances are controlled by a characteristic X-ray dominated chemistry, mainly driven by an energetic secondary electron cascade. In this work, we aim at identifying molecular photochemically induced fingerprints in the transmission spectra of a giant planet atmosphere. We have developed a numerical code capable of synthesizing transmission spectra with arbitrary spectral resolution, exploiting updated infrared photoabsorption cross sections. Chemical mixing ratios are computed using a photochemical model, tailored to investigate high energy ionization processes. We find that in case of high levels of stellar activity, synthetic spectra in both low and high resolutions show significant, potentially observable out-of-equilibrium signatures arising mainly from CO, CH$_4$, C$_2$H$_2$, and HCN.Comment: The paper has been accepted for publication in The Planetary Science Journal (PSJ

Discrete-time dynamic modeling for software and services composition as an extension of the Markov chain approach

Abstract-Discrete Time Markov Chains (DTMCs) and Continuous Time Markov Chains (CTMCs) are often used to model various types of phenomena, such as, for example, the behavior of software products. In that case, Markov chains are widely used to describe possible time-varying behavior of "self-adaptive" software systems, where the transition from one state to another represents alternative choices at the software code level, taken according to a certain probability distribution. From a control-theoretical standpoint, some of these probabilities can be interpreted as control signals and others can just be observed. However, the translation between a DTMC or CTMC model and a corresponding first principle model, that can be used to design a control system is not immediate. This paper investigates a possible solution for translating a CTMC model into a dynamic system, with focus on the control of computing systems components. Notice that DTMC models can be translated as well, providing additional information

Autotuning control structures for reliability-driven dynamic binding

Abstract-This paper explores a formally grounded approach to solve the problem of dynamic binding in serviceoriented software architecture. Dynamic binding is a widely adopted mean to automatically bind exposed software interfaces to actual implementations. The execution of an operation on one or another implementation, though providing the same result, could turn out in different quality of service, e.g. due to failure occurrence. Dynamic binding is thus of primary importance to achieve what in the Software Engineering domain is called "selfadaptiveness", the capability to preserve a desired quality of service, if this is feasible. It is important to reach this goal also in the presence of environmental fluctuations -a route congestion increase -or even abrupt variations -a server breakdown. A quite general dynamic binding problem is here reformulated as a discrete-time feedback control one, and the use of autotuning techniques is discussed, extending previous research, in a view to guaranteeing the desired quality of service without the need for computationally-intensive optimisations