Quantifying lithological variability in the mantle

We present a method that can be used to estimate the amount of recycled material present in the source region of mid-ocean ridge basalts by combining three key constraints: (1) the melting behaviour of the lithologies identified to be present in a mantle source, (2) the overall volume of melt production, and (3) the proportion of melt production attributable to melting of each lithology. These constraints are unified in a three-lithology melting model containing lherzolite, pyroxenite and harzburgite, representative products of mantle differentiation, to quantify their abundance in igneous source regions. As a case study we apply this method to Iceland, a location with sufficient geochemical and geophysical data to meet the required observational constraints. We find that to generate the 20 km of igneous crustal thickness at Iceland's coasts, with 30±10%30±10% of the crust produced from melting a pyroxenitic lithology, requires an excess mantle potential temperature (ΔTp) of ⩾130 °C (View the MathML sourceTp⩾1460°C) and a source consisting of at least 5% recycled basalt. Therefore, the mantle beneath Iceland requires a significant excess temperature to match geophysical and geochemical observations: lithological variation alone cannot account for the high crustal thickness. Determining a unique source solution is only possible if mantle potential temperature is known precisely and independently, otherwise a family of possible lithology mixtures is obtained across the range of viable ΔTp. For Iceland this uncertainty in ΔTp means that the mantle could be >20% harzburgitic if View the MathML sourceΔTp>150°C (View the MathML sourceTp>1480°C). The consequences of lithological heterogeneity for plume dynamics in various geological contexts are also explored through thermodynamic modelling of the densities of lherzolite, basalt, and harzburgite mixtures in the mantle. All lithology solutions for Iceland are buoyant in the shallow mantle at the ΔTp for which they are valid, however only lithology mixtures incorporating a significant harzburgite component are able to reproduce recent estimates of the Iceland plume's volume flux. Using the literature estimates of the amount of recycled basalt in the sources of Hawaiian and Siberian volcanism, we found that they are negatively buoyant in the upper mantle, even at the extremes of their expected ΔTp. One solution to this problem is that low density refractory harzburgite is a more ubiquitous component in mantle plumes than previously acknowledged

Learning Together: forging belonging among students with experience of the criminal justice system

The Learning Together methodology at Liverpool John Moores University attempts to open up higher education for people with criminal convictions.  Applied in a criminal justice course, Learning Together aims to create a safe space for criminal justice academics, students, service users and practitioners to come together and form a unique community of practice whereby scholarly activity, life events and professional experience are recognised, applied and practiced within and beyond the classroom.  As the initiative has grown and developed, course co-creators have recognised how community engagement as a pedagogical framework holds the ability to reduce cultural distance between academic researchers and the communities in which they work whilst at the same time enriching learning and strengthening communities.  This paper provides an insight into the initiative and reflects on how belonging can be embedded via a connected curriculum framework.&nbsp

Developing a creative pedagogy to understand the university experience of non-traditional students

Despite the presence of a widening participation agenda, people with criminal convictions face a number of barriers accessing and participating in higher education (Office for Students, 2019). This may be due to unspent criminal convictions (Unlock, 2018), limited confidence and self-esteem (Champion and Noble, 2016), a lack of previous educational attainment (Prison Reform Trust, 2017) and/or presence of risk-adverse, bureaucratic, university admission processes (Bhattacharya et al., 2013). As a result, people with criminal convictions are not only under-represented throughout the sector (Unlock, 2018) but completely overlooked when it comes to understanding their university experience. To address this longstanding issue, the authors have developed an educational opportunity (utilising the Learning Together programme) for criminal justice academics, students, practitioners and service users to come together and learn from one another through lived experience, professional practice and Creative Pedagogy. Learning Together was originally developed and implemented by Dr Amy Ludlow and Dr Ruth Armstrong at the University of Cambridge to provide opportunities for university students to learn alongside people serving a custodial sentence (Armstrong and Ludlow, 2016). &nbsp

Calcium supplements and cancer risk : a meta-analysis of randomised controlled trials

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Developing a creative pedagogy to understand the university experience of non-traditional students

Despite the presence of a widening participation agenda, people with criminal convictions face a number of barriers accessing and participating in higher education (Office for Students, 2019). This may be due to unspent criminal convictions (Unlock, 2018), limited confidence and self-esteem (Champion and Noble, 2016), a lack of previous educational attainment (Prison Reform Trust, 2017) and/or presence of risk-adverse, bureaucratic, university admission processes (Bhattacharya et al., 2013). As a result, people with criminal convictions are not only under-represented throughout the sector (Unlock, 2018) but completely overlooked when it comes to understanding their university experience. To address this longstanding issue, the authors have developed an educational opportunity (utilising the Learning Together programme) for criminal justice academics, students, practitioners and service users to come together and learn from one another through lived experience, professional practice and Creative Pedagogy. Learning Together was originally developed and implemented by Dr Amy Ludlow and Dr Ruth Armstrong at the University of Cambridge to provide opportunities for university students to learn alongside people serving a custodial sentence (Armstrong and Ludlow, 2016).

The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney : the percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole kidney stones randomised controlled trial (PUrE RCT) protocol

PUrE is a UK Collaborative Trial funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project no. 13/152/02). The Health Services Research Unit is funded by the Chief Scientists Office of the Scottish Government Health Directorates. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the Health Technology Assessment Programme, the National Institute of Health Research, the National Health Service or the Department of Health. The funder (through their peer-review and funding board review process) approved the study proposal but had no role in the collection, analysis or interpretation of data or writing of the report.Peer reviewedPublisher PD

Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester

Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL. Study design: Employing a prospective case-controlled design we studied 20 pregnant women with a history of RPL and 20 age-matched women with no history of RPL (NRPL). We measured serum relaxin-2 levels by ELISA at 6-8. 10-12, 20, and 34 weeks gestation and in cord blood, and maternal uterine artery Doppler resistance index (RI) at >= 10 weeks gestation. Results: Relaxin rose to a peak at 12 weeks, and gradually declined towards term. At all gestations, women with a history of RPL had lower RLX levels than women without. At 10-12 weeks gestation, uterine artery RI correlated with serum RLX for both RPL and NRPL. In the NRPL group at 10-12 weeks the presence of a notched waveform was associated with higher RLX levels than the absence of a notch (mean 2.1 ng/ml vs. 1.3 ng/ml, P < 0.05) and also at 20 weeks (2.1 ng/ml vs. 0.95 ng/ml, P < 0.05) but no such difference was seen in the RPL group. Umbilical venous RLX was 4-fold higher in the RPL group than the NRPL group. Conclusion: Women with a history of RPL demonstrate attenuated levels of serum RLX across all pregnancy trimesters. How dysregulated RLX metabolism may contribute to adverse pregnancy outcome in RPL requires further investigation. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved

FGFR3 and TP53 mutation analysis in inverted urothelial papilloma: incidence and etiological considerations

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Shockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones : the TISU non-inferiority RCT

Acknowledgements The authors wish to thank the patients who participated in the TISU trial.We also thank Stanley Coutts (patient representative) and Charles Clark (patient representative and co-applicant) for their contribution to the design of the participant-facing documents (patient information sheet and questionnaires); Sharon Wren for her secretarial support and data management; previous data co-ordinators, Jessica Wood and Margery Heath, for their data and trial management support; the CHaRT programming team led by Gladys McPherson (to 2016) and Mark Forrest (2016–present); other staff within CHaRT and the HSRU for their assistance with the trial (Cynthia Fraser); members of the PMG for their ongoing advice and support of the trial, plus the independent members of the TSC and DMC; and the staff at the recruitment sites who facilitated the recruitment, treatment and follow-up of trial participants (all listed below); and, finally, we would like to thank the National Institute for Health Research and the Health Technology Assessment programme for funding the TISU trial. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 26, No. 19. See the NIHR Journals Library website for further project information.Peer reviewedPublisher PD