THE SYNTHESIS OF SOME CYCLOHEXANE DERIVATIVES AND THEIR RELATED ACYCLIC ANALOGUES AS POTENTIAL ANTIMICROBIAL AGENTS

This thesis consists of syntheses of a number of B-amino ketones, a class of compounds known to possess a wide range of pharmacological properties. Two main series (B) and (D) were prepared to examine the relation-ship between chemical structure and antimicrobial activity. The related cyclic analogs (A) and (C) were also prepared for comparison of their antimicrobial properties with that of the above two series (B) and (D), in order to give information regarding the distance necessary for high biological activity between groups present in these series of compounds

Framing the features of Brownian motion and thermophoresis on radiative nanofluid flow past a rotating stretching sheet with magnetohydrodynamics

AbstractThis article addresses the combined effects of chemical reaction and viscous dissipation on MHD radiative heat and mass transfer of nanofluid flow over a rotating stretching surface. The model used for the nanofluid incorporates the effects of the Brownian motion and thermophoresis in the presence of heat source. Similarity transformation variables have been used to model the governing equations of momentum, energy, and nanoparticles concentration. Runge-Kutta-Fehlberg method with shooting technique is applied to solve the resulting coupled ordinary differential equations. Physical features for all pertinent parameters on the dimensionless velocity, temperature, skin friction coefficient, and heat and mass transfer rates are analyzed graphically. The numerical comparison has also presented for skin friction coefficient and local Nusselt number as a special case for our study. It is noted that fluid velocity enhances when rotational parameter is increased. Surface heat transfer rate enhances for larger values of Prandtl number and heat source parameter while mass transfer rate increases for larger values of chemical reaction parameter

The effect of women director on banks performance: Evidence from Pakistan

Code of Corporate governance around the globe encourage the appearance of women in corporate board. The objective of this research is to observe the association between board gender diversity and its effects on bank performance which is based on evidence of Pakistan. The sample of this research comprises of 10 listed banks of Pakistan. Secondary data has been collected of 12 years from 2005 to 2016. Bank financial performance is measured through ROA and ROE. Analysis is done through descriptive statistics and linear regression are applied on the data through different tests such as Heteroscedasticity, Stationary of the data, Multicollinearity is tested through Dickey fuller and Augmented Dickey fuller approaches. The study summarizes that there is an insignificant association between board gender diversity and banks performance in Pakistan, it concludes that this study does not support the developed hypothesis that woman on board has insignificant effect on bank financial performance. The finding of this study recommends to use a large sample of banks with difference methodologies such as surveys, case studies and qualitative research to find out the causes of the question that why the women on board decreasing the financial performance

Evaluating Tire Pressure Control System to Improve Productivity and Mitigate Pavement Damage

The introduction of the use of Tire Pressure Control Systems (TPCS) to improve the productivity of the Canadian trucking industry is gaining momentum. The imposition of seasonal load restrictions (SLR) on the thaw-weakened secondary roads interrupts the transportation of raw materials to processing facilities For the forestry industry in particular, this has very significant impacts on productivity and costs. FPInnovations-Feric Division (Feric) has investigated the potential for TPCS-equipped trucks to travel with full, legal loading during the SLR period without accelerating road wear and tear. The TPCS monitors and adjusts the inflation pressure of the trucks’ tires while driving and allows the operator to optimize the inflations for changes in loading, travel speed, or road quality encountered in the trip. This thesis describes an investigation to determine whether TPCS can be used to mitigate traffic generated damage to secondary roads and also reduce the need to implement load restrictions. The project involves a partnership with the Ontario Ministry of Transportation Ontario (MTO), Forest Engineering Research Institute of Canada (FERIC), Ontario Ministry of Natural Resources (MNR) and the Centre for Pavement and Transportation Technology (CPATT) located at the University of Waterloo. The thesis will describe the methodology, design, and instrumentation of the two test sites which are located in Dryden, Ontario and Chapleau, Ontario. In addition, repeated Portable Falling Weight Deflectometer (PFWD) testing is being carried out at these sites and the initial results of this examination and associated impacts of the environment and traffic on the road will be presented. This study also involves looking into the reliability of using the portable FWD, offering a lower cost alternative instead of the trailer mounted FWD to monitor pavement strength for the identification the SLR period. The use of innovative sensors and data collection techniques are proving to be very informative and are advancing pavement engineering knowledge. Moreover, the thesis is aimed at exploring the possibilities of achieving the current objectives of the government DOTs such as TPCS potential for addressing the timber industry in crisis, reduced road maintenance budgets, and global warming increasing road damage

On a New Numerical Approach on Micropolar Fluid, Heat and Mass Transfer Over an Unsteady Stretching Sheet Through Porous Media in the Presence of a Heat Source/Sink and Chemical Reaction

The problem of MHD micropolar fluid, heat and mass transfer over unsteady stretching sheet through porous medium in the presence of a heat source/sink and chemical reaction is presented in this chapter. By applying suitable similarity transformations, we transform the governing partial differential equations into a system of ordinary differential equations. We then apply the recently developed numerical technique known as the Spectral Quasi-Linearization Method. The validity of the accuracy of the technique is checked against the bvp4c routine method. Numerical results for the surface shear stresses, Nusselt number and the Sherwood number are presented in tabular form. Also numerical results for the velocity, temperature and concentration distribution are presented in graphical forms, illustrating the effects of varying values of different parameters

Wearable Near Infrared Spectroscopy for Noninvasive Assessment of Cerebral Oxygenation in Pediatric Sickle Cell Disease

About 1 out of every 13 African American infants are born with the Sickle Cell Trait. Sickle Cell Disease (SCD) has a profound effect on the brain due to chronic anemia and abnormal perfusion. Indeed, the risk of stroke is 300 times higher than the general population. Assessment of cerebral oxygenation in SCD is important to screen the risk of stroke and monitoring of therapeutic effects. To address this need, the technical solution that we propose is a photonic device using functional Near Infrared Spectroscopy (fNIRS) that noninvasively measures oxyhemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb) levels in the bloodstream. We have built our prototype fNIRS device that consists of an ESP-32 microcontroller with a built-in Digital to Analog and Analog to Digital converter channels (DAC and ADC), three Operational Amplifiers (two AD8655 and one OPA363), two LEDs for emitting light into the skin tissue, and a Photodiode for measuring the remitted light intensity. Oxy-Hb has a higher absorption rate at lower wavelengths, while deoxy-Hb has a higher absorption rate at higher wavelengths. Thus, we use 650 nm and 950nm wavelengths to accurately measure oxy-Hb and deoxy-Hb. Using the Beer-Lambert law, we can determine the changes in oxygenation between the two. We are currently conducting performance tests on a set of optical phantoms mimicking biological tissue optical properties. This bench-top verification demonstrates that our prototype can noninvasively track the changes of tissue oxygenation level and will be ready for further validation on human subjects in the future

Correlation of cyclin D1 between hormones receptors and other clinical parameters in invasive breast carcinoma

Background: Breast carcinoma is the most common malignancy in women. The prognosis of breast carcinoma is determined by different prognostic factors including age of patients, type of tumour, stage of tumours, grade of tumors, presence or absence of metastasis and hormones receptor status. The present study was conducted to assess the expression of cyclin D1 in invasive breast carcinoma and its correlation with age, tumour grade, lymph node metastasis and hormones receptors (estrogen receptors and progesterone receptors).Methods: Present study was conducted in department of pathology UPUMS, Saifai, Etawah, Uttar Pradesh. This was a prospective cross sectional observation study conducted on 21 mastectomy specimen from January 2019 to June 2020, diagnosed as invasive breast carcinoma on routine haematoxylin and eosin stain. Immunohistochemistery marker was scored by using allred scoring methods. Grading was calculated according to Nottingham grading system.Results: It was observed out of 21 cases 9 (42.8%) cases were showing cyclin D1 positivity. In our study 14 cases were estrogen receptor and progesterone receptor positive, out of 14 ER and PR positive cases 9 (64.2%) cases showing cyclin D1 positivity. There was significant correlation between cyclin D1 and hormones receptors (ER and PR). No significant correlation between cyclin D1and age, tumour grade and lymph node metastasis.Conclusions: Present study depicts significant correlation between cyclin D1 and hormones receptors (ER and PR). No significant correlation between cyclin D1and age, tumour grade and lymph node metastasis

Comparison of Optimal Homotopy Asymptotic and Adomian Decomposition Methods for a Thin Film Flow of a Third Grade Fluid on a Moving Belt

We have investigated a thin film flow of a third grade fluid on a moving belt using a powerful and relatively new approximate analytical technique known as optimal homotopy asymptotic method (OHAM). The variation of velocity profile for different parameters is compared with the numerical values obtained by Runge-Kutta Fehlberg fourth-fifth order method and with Adomian Decomposition Method (ADM). An interesting result of the analysis is that the three terms OHAM solution is more accurate than five terms of the ADM solution and this thus confirms the feasibility of the proposed method

Impact of marble powder amendment on hydraulic properties of a sandy soil

Marble powder is one of carbonate rock amendments that is used to improve soil reaction. We hypothesized that the powdered marble addition can cause favorable changes in hydraulic properties of sandy soils. Six levels of marble powder addition to an aridisol soil (0%; M0; 5%; M5; 10%; M10; 15%; M15; 20%; M20 and 25%, M25; by bulk volume) were analyzed in triplicate. The saturated hydraulic conductivity and soil water retention curves were obtained. Pore space properties were investigated using soil water retention curves, mercury intrusion porosimetry and scanning electron microscopy. The saturated hydraulic conductivity significantly decreased (between 83 and 97% for M5 and M25 respectively) and parameters α and n of the van Genuchten model significantly decreased in marble-amended soils. Both field capacity and permanent wilting point increased with the addition of marble powder. Plant-available water, increased significantly until 10% of marble powder application; higher percentages of application did not provide additional significant changes in the plant-available water. Pore space distributions from soil water retention curves parameters showed an increase in the pore size range and a decrease in the average pore size; pore space distribution from the scanning electron microscopy also showed the presence of a new family of dominant pore sizes which was not detected by the soil water retention curves parameters approach. It was concluded that the addition of marble powder can improve the ability of soil to store water providing an advantage for irrigation water management in water scarce environments. Further research will have to address the impact of marble powder amendment under field semi-arid conditions.This work was partially funded by the project GRE17-12 from the University of Alicante (2018-2019)

A rare case of Aeromonas hydrophila catheter related sepsis in a patient with chronic kidney disease receiving steroids and dialysis: a case report and review of Aeromonas infections in chronic kidney disease patients

Aeromonas hydrophila (AH) is an aquatic bacterium. We present a case of fifty-five-year-old gentleman with chronic kidney disease (CKD) due to crescentic IgA nephropathy who presented to us with fever. He was recently pulsed with methyl prednisolone followed by oral prednisolone and discharged on maintenance dialysis through a double lumen dialysis catheter. Blood culture from peripheral vein and double lumen dialysis catheter grew AH. We speculate low immunity due to steroids and uremia along with touch contamination of dialysis catheter by the patient or dialysis nurse could have led to this rare infection. Dialysis catheter related infection by AH is rare. We present our case here and take the opportunity to give a brief review of AH infections in CKD patients