Evaluation of relationship between orthodontic treatment need according Dental Aesthetic Index (DAI) and student’s perception in 11-14 year old students in the city of Shiraz in 2012

Background: Although the demand for orthodontic treatment is affected by understanding the needs for treatment and costs, patients’ concerns do not always match with expert’s assessments. To gain a clearer understanding of children’s orthodontic needs, treatment recommendations and how an abnormality can affect a child’s quality of life is critical. Information on the relationship between assessment of need for treatment and an individual’s perception of need for orthodontic treatment is of great interest for orthodontic service providers. The present study aimed to assess the relationship between need for orthodontic treatment according to Dental Aesthetic Index (DAI) and individuals’ perception of need for treatment in 11-14 year old students.Methods: In this study, 240 primary and middle school students from the four educational districts of Shiraz were selected through multi-stage random sampling and completed the study questionnaire. Then dental examination was done by the dentist according to DAI index to determine the student’s need for orthodontic treatment.Results: According to the results, 73.8% of the students had DAI score of13-25 (little or no need for treatment), 15.2% had DAI score of 25-30 (specific malocclusion with elective need for treatment), 4.4% had DAI score of 30-35 (severe malocclusion with extreme need for treatment), and 6.7% had DAI score exceeding 35 indicating their serious need for orthodontic treatment. The total mean score of DAI was 23.57.Conclusion: The results revealed a significant relationship between the students’ perception of need for treatment and professional assessment of need for orthodontic treatment based on DAI index (P = 0.002).

Synthesis and Characterization of Simvastatin-N-succinyl chitosan-citicoline Conjugated Form Intended for Improving Alzheimer’s Disease in Long Term Use of Simvastatin

Introduction: Simvastatin is a semisynthesis statin. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme of cholesterol synthesis, in AMPK (AMP-activated protein kinase) signaling pathway. Simvastatin is able to cross blood brain barrier more than the other statins, due to its lipophilic nature. There is controversy about the effect of simvastatin on Alzheimer’s disease (AD). For example, simvastatin can induce AD through insulin signaling pathway but can ameliorate AD via MAPK (Mitogen-Activated Protein Kinase) signaling pathway.  In this study, we report the synthesis of a conjugated form of simvastatin with citicoline, to block negative effect of simvastatin on insulin signaling pathway and increase positive effect of simvastatin on MAPK signaling pathway and chitosan as a linker between these two drugs.   Methods and Results: for simvastatin-n-succinyl chitosan-citicoline synthesis, chitosan reacted with succinic acid to form n-succinyl chitosan. Then simvastatin connected to n-succinyl chitosan via acetylation reaction. After 24 hours citicoline was added to reaction media. H-NMR and FT-IR were done to examine whether the conjugation reaction has been done or not. Characterization and morphology tests have been done on reaction result. H-NMRresults approved the synthesis of drug-polymer. FT-IR results showed both amide and ester peaks.  Maximum absorptions (λmax) of all primary chemicals were seen in UV visible spectroscopy results of conjugated form.SEM result showed that the conjugated form has nanoparticulate structure in size range of 100-300 nanometers. X-RD result showed a peak under 25 theta. Another characterization test wasRBC hemolysis with six different concentrations, in which normal saline was negative control and Triton was positive control. Conclusions: Conjugation of lipophilic simvastatin with hydrophilic citicoline to improve AD can be done with helping of a polymer which is rich in carboxylic acid

Quantitative and qualitative characteristics of Persian oak along altitudinal gradation and gradient (case study: Ilam province, Iran)

Quantitative and qualitative characteristics of Persian oak (Quercus persica) were studied in relation to altitude and slope variations in Ilam province. A total area of 1,500 m2 (30 × 50 m) was covered in five altitudinal classes ranging from 800 to 1,800 m a.s.l. Samples were taken based on a systematic random sampling method with 24 sample plots at each class. In total, 120 sample plots (in five classes) were collected covering four gradient categories ranging from 60%. An analysis of variance (ANOVA) was carried out to compare differences between group means in gradient categories and Duncan’s post-hoc test was performed to reveal differences between the means of various quantitative characteristics (e.g. growing stock, basal area, diameter at breast height, tree height and regeneration) and the altitudinal classes. The Kruskal-Wallis test was used to examine the differences between the means of qualitative variables and different altitudes and slopes categories. The results indicated that variations with altitudes may have a higher impact than slopes on the quantitative characteristics of the oak stands in the region while the qualitative variables of the native species were influenced by both altitudes and slope variations

Analysis of Blood Transfusion Data Using Bivariate Zero-Inflated Poisson Model: A Bayesian Approach

Recognizing the factors affecting the number of blood donation and blood deferral has a major impact on blood transfusion. There is a positive correlation between the variables "number of blood donation" and "number of blood deferral": as the number of return for donation increases, so does the number of blood deferral. On the other hand, due to the fact that many donors never return to donate, there is an extra zero frequency for both of the above-mentioned variables. In this study, in order to apply the correlation and to explain the frequency of the excessive zero, the bivariate zero-inflated Poisson regression model was used for joint modeling of the number of blood donation and number of blood deferral. The data was analyzed using the Bayesian approach applying noninformative priors at the presence and absence of covariates. Estimating the parameters of the model, that is, correlation, zeroinflation parameter, and regression coefficients, was done through MCMC simulation. Eventually double-Poisson model, bivariate Poisson model, and bivariate zero-inflated Poisson model were fitted on the data and were compared using the deviance information criteria (DIC). The results showed that the bivariate zero-inflated Poisson regression model fitted the data better than the other models

Psychometric properties of the Postgraduate Hospital Educational Environment Measure in an Iranian hospital setting

Background: Students’ perceptions of the educational environment are an important construct in assessing and enhancing the quality of medical training programs. Reliable and valid measurement, however, can be problematic – especially as instruments developed and tested in one culture are translated for use in another. Materials and method: This study sought to explore the psychometric properties of the Postgraduate Hospital Educational Environment Measure (PHEEM) for use in an Iranian hospital training setting. We translated the instrument into Persian and ensured its content validity by back translation and expert review prior to administering it to 127 residents of Urmia University of Medical Science. Results: Overall internal consistency of the translated measure was good (a=0.94). Principal components analysis revealed five factors accounting for 52.8% of the variance. Conclusion: The Persian version of the PHEEM appears to be a reliable and potentially valid instrument for use in Iranian medical schools and may find favor in evaluating the educational environments of residency programs nationwide

Job burnout and some of its risk factors on the health workers (Behvarz) in Koohrang County, I.R.Iran, in 2010

زمینه و هدف : فرسودگی شغلی، شامل خستگی عاطفی ، مسخ شخصیت و کاهش موفقیت فردی است و زمانی که توانایی های فرد برای تقاضاهای محیط کار کافی نباشد علائم آن آشکار می شود. کارکنان نظام سلامت به دلیل مواجهه با استرس های فیزیکی و روانی در معرض فرسودگی می باشند. این مطالعه با هدف تعیین میزان فرسودگی شغلی بهورزان و بررسی ارتباط خصوصیات جمعیت شناختی با آن انجام گرفت . روش بررسی: این پژوهش توصیفی-تحلیلی، بر روی همه بهورزان شهرستان کوهرنگ ( 81 نفر) در آبانماه سال 1389 انجام شد . ابزار گردآوری داده ها پرسشنامه­ای شامل اطلاعات جمعیت شناختی و پرسشنامه فرسودگی شغلی مازلاک ( MBI ) بود. پرسشنامه توسط بهورزان تکمیل و داده­ها با استفاده از آزمون های آماری ANOVA ، ضریب همبستگی اسپیرمن و آزمون تی مستقل تحلیل گردید. یافته ها: از نظر فراوانی، کاهش موفقیت فردی زیاد ( 5/24 ) ، خستگی عاطفی زیاد ( 6/4 ) و مسخ شخصیت زیاد ( 7/2 ) ، به ترتیب از بیشترین فراوانی و از نظر شدت، خستگی عاطفی شدید ( 7/6 ) و مسخ شخصیت شدید ( 3/1 ) ، به ترتیب از بیشترین شدت برخوردار بودند. هیچ یک از بهورزان کاهش شدید موفقیت فردی را گزارش ننمود. میزان خستگی عاطفی با مسخ شخصیت و میزان کاهش موفقیت فردی با خستگی عاطفی رابطه معنی داری داشت (001/0 > P ) . بین جنس، سن، وضعیت تأهل، سابقه کار، نوع استخدام و میزان تحصیلات بهورزان و فرسودگی رابطه معنی داری دیده نشد. نتیجه گیری: این مطالعه نشان داد که فراوانی و شدت فرسودگی شغلی در بهورزان شهرستان کوهرنگ پایین است که از دلایل آن می توان به موقعیت اجتماعی مناسب، نزدیکی محل کار و زندگی، درآمد متناسب با حجم کار و تحصیلات، امنیت شغلی، سطح توقع پایین و شرایط آب و هوایی و فرهنگی منطقه اشاره کر

Investigation the effect of program based on Roy’s adaptation model on general health of offspring of people with multiple sclerosis

Background and aim: General health is not merely the absence of illness or disability, but a state of well-being that enables one to cope with the stresses of life, become professionally and academically useful. Parents' multiple sclerosis complications have potential effects on the health of their offspring. Therefore, the aim of this study was to evaluate the effect of program based on Roy’s adaptation model on general health of offspring of patients with multiple sclerosis. Methods: This semi-experimental study was done on 80 offspring of parents with multiple sclerosis, member of the MS association and the welfare organization of Shahrekord in 2018. Samples were selected as available, Roy form were completed by them and those who scored less than 80%, entered the study. The general health questionnaire was completed in both groups before, after and two months after the intervention. In the intervention group, a program based Roy’s adaptation model was developed, implemented and followed up for six session (2session education, of general education and 4 session direct intervention). Data were analyzed by SPSS21 software and statistical tests. Results: Before intervention, the mean of general health scores between the two groups was not statistically significant (p = 0.716). But there was a significant difference immediately after (p = 0.025) and two months after the intervention (p <0.001). General health scores in the intervention group showed a significant increase. Conclusion: Using a program based on Roy’s adaptation model has a positive effect on general health of offspring of people with multiple sclerosis. Keywords: Multiple Sclerosis, Roy “adaptation Model, Stress, General Health, offsprin

Therapeutic targets of natural products for the management of cardiovascular symptoms of coronavirus disease 2019

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first occurred in China in December 2019 and subsequently spread all over the world with cardiovascular, renal, and pulmonary symptoms. Therefore, recognizing and treating the cardiovascular sign and symptoms that caused by coronavirus disease 2019 (COVID-19) can be effective in reducing patient mortality. To control the COVID-19-related cardiovascular symptoms, natural products are considered one of the promising choices as complementary medicine. Scientists are struggling to discover new antiviral agents specific to this virus. In this review, the natural products for management of cardiovascular symptoms of COVID-19 are categorized into three groups: (a) natural products with an impact on angiotensin II type 1 receptor; (b) natural products that inhibit angiotensin-converting enzyme activity; and (c) natural products that mimic adenosine activity. All these natural products should undergo clinical investigations to test their efficacy, safety, and toxicity in the treatment of cardiovascular symptoms of COVID-19. This article summarizes agents with potential efficacy against COVID-19-related cardiovascular symptoms

Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review

Marine sponges (porifera) have proved to be a prolific source of unique bioactive secondary metabolites, among which the alkaloids occupy a special place in terms of unprecedented structures and outstanding biological activities. Identification of active cytotoxic alkaloids extracted from marine animals, particularly sponges, is an important strive, due to lack of knowledge on traditional experiential and ethnopharmacology investigations. In this report, a comprehensive survey of demospongian bioactive alkaloids in the range 1987-2020 had been performed with a special emphasis on the potent cytotoxic activity. Different resources and databases had been investigated, including Scifinder (database for the chemical literature) CAS (Chemical Abstract Service) search, web of science, Marin Lit (marine natural products research) database. More than 230 representatives of different classes of alkaloids had been reviewed and classified, different genera belonging to the phylum porifera had been shown to be a prolific source of alkaloidal molecules, including Agelas sp., Suberea sp., Mycale sp., Haliclona sp., Epipolasis sp., Monanchora sp., Crambe sp., Reniera sp., and Xestospongia sp., among others. The sufficient production of alkaloids derived from sponges is a prosperous approach that requires more attention in future studies to consider the constraints regarding the supply of drugs, attained from marine organisms

Prevalence and Correlates of Psychiatric Disorders in a National Survey of Iranian Children and Adolescents

Objective: Considering the impact of rapid sociocultural, political, and economical changes on societies and families, population-based surveys of mental disorders in different communities are needed to describe the magnitude of mental health problems and their disabling effects at the individual, familial, and societal levels. Method: A population-based cross sectional survey (IRCAP project) of 30 532 children and adolescents between 6 and 18 years was conducted in all provinces of Iran using a multistage cluster sampling method. Data were collected by 250 clinical psychologists trained to use the validated Persian version of the semi-structured diagnostic interview Kiddie-Schedule for Affective Disorders and Schizophrenia-PL (K-SADS-PL). Results: In this national epidemiological survey, 6209 out of 30 532 (22.31%) were diagnosed with at least one psychiatric disorder. The anxiety disorders (14.13%) and behavioral disorders (8.3%) had the highest prevalence, while eating disorders (0.13%) and psychotic symptoms (0.26%) had the lowest. The prevalence of psychiatric disorders was significantly lower in girls (OR = 0.85; 95% CI: 0.80-0.90), in those living in the rural area (OR = 0.80; 95% CI: 0.73-0.87), in those aged 15-18 years (OR = 0.92; 95% CI: 0.86-0.99), as well as that was significantly higher in those who had a parent suffering from mental disorders (OR = 1.96; 95% CI: 1.63-2.36 for mother and OR = 1.33; 95% CI: 1.07-1.66 for father) or physical illness (OR = 1.26; 95% CI: 1.17-1.35 for mother and OR = 1.19; 95% CI: 1.10-1.28 for father). Conclusion: About one fifth of Iranian children and adolescents suffer from at least one psychiatric disorder. Therefore, we should give a greater priority to promoting mental health and public health, provide more accessible services and trainings, and reduce barriers to accessing existing services