Managing malignant pleural effusion with an indwelling pleural catheter: factors associated with spontaneous pleurodesis

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Identifying the critical success factors for relationship management in PPP projects

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Containment of fast scanning computer network worms

This paper presents a mechanism for detecting and containing fast scanning computer network worms. The countermeasure mechanism, termed NEDAC, uses a behavioural detection technique that observes the absence of DNS resolution in newly initiated outgoing connections. Upon detection of abnormal behaviour by a host, based on the absence of DNS resolution, the detection system then invokes a data link containment system to block traffic from the host. The concept has been demonstrated using a developed prototype and tested in a virtualised network environment. An empirical analysis of network worm propagation has been conducted based on the characteristics of reported contemporary vulnerabilities to test the capabilities of the countermeasure mechanism. The results show that the developed mechanism is sensitive in detecting and blocking fast scanning worm infection at an early stage

Building integrated project and asset management teams for sustainable built infrastructure development

Purpose – This paper aims to investigate the relevance of the relationally integrated value networks (RIVANS) concept for integrating project management (PM) and asset management (AM) for total asset management (TAM). The specific objectives are to test the RIVANS for TAM concept postulated by Kumaraswamy (2011) and Kumaraswamy et al. (2012); discover ways to enable PM and AM teams to work in an integrated manner; and recommend strategies and operational measures to promote greater team integration in the industry. Design/methodology/approach – This study is based in Hong Kong with parallel studies in the UK, Singapore and Sri Lanka. Through a comprehensive questionnaire, a case study on an organization engaged in both design and construction and operations and maintenance (O&M) works, interviews and hosting a workshop (all conducted with experienced industry practitioners and experts), a set of recommendations are derived to guide the industry toward greater team integration. Findings – Early involvement of O&M staff is important for better anticipating obstacles and learning from past experiences, but PM and AM teams generally work independently with limited interaction. Priorities of the stakeholders are often different. Knowledge management is increasingly important, but knowledge sharing is not always a priority. The three focus areas in the set of recommendations developed from Hong Kong are: organizational/management structure, procurement strategies and operational mechanisms; fostering culture of team building and providing additional means of communication; and informal communication tools. Originality/value – There has been little research into the communication, interaction and integration between PM and AM priorities and teams. However, increasing industry emphasis on sustainable buildings, end-user satisfaction and designing for maintainability dictates that PM and AM teams must work closer together, hence the imperative for mapping useful directions to be pursued.postprin

Application of Relationally Integrated Value Networks in the Implementation of BIM for Better Life Cycle Considerations of Buildings

Track: TG80Emerging as an innovative tool with rapidly increasing usage in the construction industry, Building Information Modeling (BIM) can provide a platform to enable two dimensions of information exchange, namely i) information sharing among relevant participants within a certain project phase; and ii) information exchange between two or more project phases. The latter is of vital importance to help achieve potential life cycle benefits of BIM. However, a significant gap exists in information flows in current BIM implementation in Hong Kong, between 'Design & Construction' (D&C) and ‘Operation & Management' (O&M). This paper discusses the potential application of a relational management framework named 'Relationally Integrated Value Networks' (RIVANS) to guide the process of information exchange between ‘D&C’ and ‘O&M’ in a BIM system. Possible causes of the above information flow gap are explored and proposals are developed based on RIVANS principles to bridge this gap. Findings and recommendations presented in this paper should pave the way for enhancing information flow in BIM across various phases of a construction project, thereby enabling integrated efforts for improving building life cycle performance.published_or_final_versio

Effect of elevated in-service temperature on the mechanical properties and microstructure of particulate-filled epoxy polymers

In civil engineering applications, epoxy-based polymers are subject to different environmental conditions including in-service temperature, which might accelerate their degradation and limit their application ranges. Recently, different particulate fillers were introduced to enhance the mechanical properties and reduce the cost of epoxy-based polymers. This paper addresses the effect of in-service elevated temperature (from room temperature to 80o C) in particulate-filled epoxy based resin containing up to 60% by volume of fire retardant and fly ash fillers through a deep understanding of the microstructure and analysis of their mechanistic response. An improvement in the retention of mechanical properties at in-service elevated temperature was achieved by increasing the percentages of fillers. The retention of compressive and split tensile strength at 80o C for the mix containing 60% fillers was 72% and 52%, respectively, which was significantly higher than the neat epoxy. Thermo-dynamic analysis showed an increase in glass transition temperature with the inclusion of fillers, while these mixes also experienced less weight loss compared to neat epoxy, indicating better thermal stability. Scanning electron microscopy images showed the formation of dense microstructures for particulate-filled epoxy based resin at elevated temperatures. This indicates that the particulate filled epoxy resin exhibits better engineering properties at in-service elevated temperatures, increasing their durability and therefore their suitability for civil engineering applications. A simplified prediction equation based on power function was proposed and showed a strong correlation to the experimental compressive and splitting tensile strength at different levels of in-service elevated temperature

The importance of endpoint selection: how effective does a drug need to be for success in a clinical trial of a possible Alzheimer's disease treatment?

To date, Alzheimer's disease (AD) clinical trials have been largely unsuccessful. Failures have been attributed to a number of factors including ineffective drugs, inadequate targets, and poor trial design, of which the choice of endpoint is crucial. Using data from the Alzheimer's Disease Neuroimaging Initiative, we have calculated the minimum detectable effect size (MDES) in change from baseline of a range of measures over time, and in different diagnostic groups along the AD development trajectory. The Functional Activities Questionnaire score had the smallest MDES for a single endpoint where an effect of 27% could be detected within 3 years in participants with Late Mild Cognitive Impairment (LMCI) at baseline, closely followed by the Clinical Dementia Rating Sum of Boxes (CDRSB) score at 28% after 2 years in the same group. Composite measures were even more successful than single endpoints with an MDES of 21% in 3 years. Using alternative cognitive, imaging, functional, or composite endpoints, and recruiting patients that have LMCI could improve the success rate of AD clinical trials

Rapid neuroinflammatory changes in human acute intracerebral hemorrhage

Objective Spontaneous intracerebral hemorrhage (ICH) is the commonest form of hemorrhagic stroke and is associated with a poor prognosis. Neurosurgical removal of intracerebral hematoma has limited benefit and no pharmacotherapies are available. In acute ICH, primary tissue damage is followed by secondary pathology, where the cellular and neuroinflammatory changes are poorly understood. Methods We studied histological changes in postmortem tissue from a cohort of spontaneous supra‐tentorial primary ICH cases (n = 27) with survival of 1–12 days, compared to a matched control group (n = 16) examined in corresponding regions. Hematoxylin–eosin and microglial (Iba1) immunolabelled sections were assessed at 0–2, 3–5, and 7–12 days post‐ICH. Results Peri‐hematoma, the observed ICH‐related changes include edema, tissue neutrophils and macrophages from day 1. Ischemic neurons and swollen endothelial cells were common at day 1 and universal after day 5, as were intramural erythrocytes within small vessel walls. Activated microglia were evident at day 1 post‐ICH. There was a significant increase in Iba1 positive area fraction at 0–2 (threefold), 3–5 (fourfold), and 7–12 days post ICH (ninefold) relative to controls. Giant microglia were detected peri‐hematoma from day 5 and consistently 7–12 days post‐ICH. Interpretation Our data indicate that neuroinflammatory processes commence from day 1 post‐ICH with changing microglial size and morphology following ICH and up to day 12. From day 5 some microglia exhibit a novel multiply nucleated morphology, which may be related to changing phagocytic function. Understanding the time course of neuroinflammatory changes, post‐ICH may reveal novel targets for therapy and brain restoration

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.

ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression is associated with poor survival. Restoration of wildtype, but not mutant ZNF750 protein uniquely inhibited the malignant phenotypes of SCC cells both in vitro and in vivo. Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750. In addition, ZNF750 potently suppressed cell migration by directly inhibiting the transactivation of LAMC2. Together, our findings characterize ZNF750 as a crucial SCC-specific suppressor and uncover its novel anticancer-associated functions

Comprehensive comparison of copy number variations detection using Illumina Omni 2.5M and Affymetrix CytoScan® arrays

Posters: Genome Structure, Variation and Function: abstract no. 552TStructural variation has been recognized as a genetic risk factor contributing to human diseases, and in particular, congenital disorders. Smaller scale copy number variations (CNVs) have also been linked to a number of neurodevelopmental phenotypes, including intellectual disability as well as autism spectrum disorders. The precise detection of CNVs is therefore necessary for ...postprin