258 research outputs found

    Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data.

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    Cancer genomic data is continually growing in complexity, necessitating improved methods for data capture and analysis. Tumors often contain multiple therapeutically relevant alterations, and co-occurring alterations may have a different influence on therapeutic response compared to if those alterations were present alone. One clinically important example of this is the existence of a resistance conferring alteration in combination with a therapeutic sensitizing mutation. The JAX Clinical Knowledgebase (JAX-CKB) (https://ckb.jax.org/) has incorporated the concept of the complex molecular profile, which enables association of therapeutic efficacy data with multiple genomic alterations simultaneously. This provides a mechanism for rapid and accurate assessment of complex cancer-related data, potentially aiding in streamlined clinical decision making. Using the JAX-CKB, we demonstrate the utility of associating data with complex profiles comprising ALK fusions with another variant, which have differing impacts on sensitivity to various ALK inhibitors depending on context

    Legal Deserts: A Multi-State Perspective on Rural Access to Justice

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    Rural America faces an increasingly dire access-to-justice crisis, which serves to exacerbate the already disproportionate share of social problems afflicting rural areas. One critical aspect of the crisis is the dearth of information and research regarding the extent of the problem and its impacts. This Article begins to fill that gap by providing surveys of rural access to justice in six geographically, demographically, and economically varied states: California, Georgia, Maine, Minnesota, South Dakota, and Wisconsin. In addition to providing insights about the distinct rural challenges confronting each of these states, the legal resources available, and existing policy responses, the Article explores common themes that emerge through this multi-state lens, with particular attention to the rural attorney shortage, thus framing a richer, broader discussion of rural access to justice. Written for a special issue on Revitalizing Rural, this Article ultimately proposes a two-step approach to alleviate rural justice deficits. First, although the information presented here provides a solid foundation, a critical need remains for ongoing, careful, and thoughtful study of the legal needs and lack of legal resources in rural areas. Second, the unique institutional, structural, and demographic characteristics of rural areas will require tailored, innovative, and data-driven solutions to match appropriate legal services with needs. We advocate a re-thinking of the roles of many justice system stakeholders, including the critical steps that legal educators can and should take to help close the rural-urban justice gap. Our hope is that this Article will inform and expand access-to-justice conversations so that they more intentionally address the legal needs of the vast rural reaches of our nation, thus furthering the ultimate goal of realizing access to justice for all Americans

    Legal Deserts

    Get PDF
    Rural America faces an increasingly dire access-to-justice crisis, which serves to exacerbate the already disproportionate share of social problems afflicting rural areas. One critical aspect of the crisis is the dearth of information and research regarding the extent of the problem and its impacts. This Article begins to fill that gap by providing surveys of rural access to justice in six geographically, demographically, and economically varied states: California, Georgia, Maine, Minnesota, South Dakota, and Wisconsin. In addition to providing insights about the distinct rural challenges confronting each of these states, the legal resources available, and existing policy responses, the Article explores common themes that emerge through this multi-state lens, with particular attention to the rural attorney shortage, thus framing a richer, broader discussion of rural access to justice. Written for a special issue on “Revitalizing Rural,” this Article ultimately proposes a two-step approach to alleviate rural justice deficits. First, although the information presented here provides a solid foundation, a critical need remains for ongoing, careful, and thoughtful study of the legal needs and lack of legal resources in rural areas. Second, the unique institutional, structural, and demographic characteristics of rural areas will require tailored, innovative, and data-driven solutions to match appropriate legal services with needs. We advocate a re-thinking of the roles of many justice system stakeholders, including the critical steps that legal educators can and should take to help close the rural-urban justice gap. Our hope is that this Article will inform and expand access-to-justice conversations so that they more intentionally address the legal needs of the vast rural reaches of our nation, thus furthering the ultimate goal of realizing access to justice for all Americans

    Interaction-driven (quasi-) insulating ground states of gapped electron-doped bilayer graphene

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    Bernal bilayer graphene has recently been discovered to exhibit a wide range of unique ordered phases resulting from interaction-driven effects and encompassing spin and valley magnetism, correlated insulators, correlated metals, and superconductivity. This letter reports on a novel family of correlated phases characterized by spin and valley ordering, observed in electron-doped bilayer graphene. The novel correlated phases demonstrate an intriguing non-linear current-bias behavior at ultralow currents that is sensitive to the onset of the phases and is accompanied by an insulating temperature dependence, providing strong evidence for the presence of unconventional charge carrying degrees of freedom originating from ordering. These characteristics cannot be solely attributed to any of the previously reported phases, and are qualitatively different from the behavior seen previously on the hole-doped side. Instead, our observations align with the presence of charge- or spin-density-waves state that open a gap on a portion of the Fermi surface or fully gapped Wigner crystals. The resulting new phases, quasi-insulators in which part of the Fermi surface remains intact or valley-polarized and valley-unpolarized Wigner crystals, coexist with previously known Stoner phases, resulting in an exceptionally intricate phase diagram

    Lyapunov Potential Description for Laser Dynamics

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    We describe the dynamical behavior of both class A and class B lasers in terms of a Lyapunov potential. For class A lasers we use the potential to analyze both deterministic and stochastic dynamics. In the stochastic case it is found that the phase of the electric field drifts with time in the steady state. For class B lasers, the potential obtained is valid in the absence of noise. In this case, a general expression relating the period of the relaxation oscillations to the potential is found. We have included in this expression the terms corresponding to the gain saturation and the mean value of the spontaneously emitted power, which were not considered previously. The validity of this expression is also discussed and a semi-empirical relation giving the period of the relaxation oscillations far from the stationary state is proposed and checked against numerical simulations.Comment: 13 pages (including 7 figures) LaTeX file. To appear in Phys Rev.A (June 1999

    Single frequency erbium fiber external cavity semiconductor laser

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    A novel external cavity configuration for stable single frequency operation of the semiconductor laser is demonstrated. By using an erbium doped fiber as the external cavity, longitudinal mode-hopping is suppressed, ensuring single frequency operation. Employing a 3m long fiber cavity, resolution-limited optical linewidths of a kHz are obtained.[This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.

    Probing the tunable multi-cone bandstructure in Bernal bilayer graphene

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    Controlling the bandstructure of Dirac materials is of wide interest in current research but has remained an outstanding challenge for systems such as monolayer graphene. In contrast, Bernal bilayer graphene (BLG) offers a highly flexible platform for tuning the bandstructure, featuring two distinct regimes. In one regime, which is well established and widely used, a tunable bandgap is induced by a large enough transverse displacement field. Another is a gapless metallic band occurring near charge neutrality and at not too strong fields, featuring rich 'fine structure' consisting of four linearly-dispersing Dirac cones with opposite chiralities in each valley and van Hove singularities. Even though BLG was extensively studied experimentally in the last two decades, the evidence of this exotic bandstructure is still elusive, likely due to insufficient energy resolution. Here, rather than probing the bandstructure by direct spectroscopy, we use Landau levels as markers of the energy dispersion and carefully analyze the Landau level spectrum in a regime where the cyclotron orbits of electrons or holes in momentum space are small enough to resolve the distinct mini Dirac cones. We identify the presence of four distinct Dirac cones and map out complex topological transitions induced by electric displacement field. These findings introduce a valuable addition to the toolkit for graphene electronics
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