External Prolonged Electrocardiogram Monitoring in Unexplained Syncope and Palpitations: Results of the SYNARR-Flash Study

AIMS: SYNARR-Flash study (Monitoring of SYNcopes and/or sustained palpitations of suspected ARRhythmic origin) is an international, multicentre, observational, prospective trial designed to evaluate the role of external 4-week electrocardiogram (ECG) monitoring in clinical work-up of unexplained syncope and/or sustained palpitations of suspected arrhythmic origin. METHODS AND RESULTS: Consecutive patients were enrolled within 1 month after unexplained syncope or palpitations (index event) after being discharged from emergency room or hospitalization without a conclusive diagnosis. A 4-week ECG monitoring was obtained by external high-capacity loop recorder (SpiderFlash-T(®), Sorin) storing patient-activated and auto-triggered tracings. Diagnostic monitorings included (i) conclusive events with reoccurrence of syncope or palpitation with concomitant ECG recording (with/without arrhythmias) and (ii) events with asymptomatic predefined significant arrhythmias (sustained supraventricular or ventricular tachycardia, advanced atrio-ventricular block, sinus bradycardia 6 s). SYNARR-Flash study enrolled 395 patients (57.7% females, 56.9 ± 18.7 years, 28.1% with syncope, and 71.9% with palpitations) from 10 European centres. For syncope, the 4-week diagnostic yield was 24.5%, and predictors of diagnostic events were early start of recording (0-15 vs. >15 days after index event) (OR 6.2, 95% CI 1.3-29.6, P = 0.021) and previous history of supraventricular arrhythmias (OR 3.6, 95% CI 1.4-9.7, P = 0.018). For palpitations, the 4-week diagnostic yield was 71.6% and predictors of diagnostic events were history of recurrent palpitations (P < 0.001) and early start of recording (P = 0.001). CONCLUSION: The 4-week external ECG monitoring can be considered as first-line tool in the diagnostic work-up of syncope and palpitation. Early recorder use, history of supraventricular arrhythmia, and frequent previous events increased the likelihood of diagnostic events during the 4-week external ECG monitoring.info:eu-repo/semantics/publishedVersio

A WebGIS tool for the dissemination of earthquake data

In 2004 a new seismic hazard map of Italy (MPS Working Group, 2004) has been released by a task force that produced an amount of new or updated data, such as a new version of the earthquake catalogue (CPTI04; CPTI Working Group, 2004) and an updated seismogenic zonation. A set of WebGIS tools has been designed for the data dissemination to the scientific community and the general public. The design of the WebGIS tools focused first on the consultation of the DBM04 macroseismic database (DBM Working Group, 2005), which contains the macroseismic intensity data-points (IDP) of the earthquakes listed in the CPTI04 catalogue. The WebGIS tool design and development process had to fulfill: 1) simplicity, 2) responsiveness and 3) readiness for future extensions. The specific requirements for the macroseismic database consultation interface were: - data access by place and by earthquake; - IDP maps with queryable points; - data download in both tabular and map format; - easily upgradable content; - quick and user friendly interface

A WebGIS tool for the dissemination of earthquake data

In 2004 a new seismic hazard map of Italy (MPS Working Group, 2004) has been released by a task force that produced an amount of new or updated data, such as a new version of the earthquake catalogue (CPTI04; CPTI Working Group, 2004) and an updated seismogenic zonation. A set of WebGIS tools has been designed for the data dissemination to the scientific community and the general public. The design of the WebGIS tools focused first on the consultation of the DBM04 macroseismic database (DBM Working Group, 2005), which contains the macroseismic intensity data-points (IDP) of the earthquakes listed in the CPTI04 catalogue. The WebGIS tool design and development process had to fulfill: 1) simplicity, 2) responsiveness and 3) readiness for future extensions. The specific requirements for the macroseismic database consultation interface were: - data access by place and by earthquake; - IDP maps with queryable points; - data download in both tabular and map format; - easily upgradable content; - quick and user friendly interface

Migration of dendritic cells across blood and lymphatic endothelial barriers.

7openopenDel Prete A; Locati M; Otero K; Riboldi E; Mantovani A; Vecchi A; Sozzani S.DEL PRETE, Annalisa; Locati, M; Otero, K; Riboldi, E; Mantovani, A; Vecchi, A; Sozzani, Silvan

Cell Lineage Commitment and Tumor Microenvironment as Determinants for Tumor-Associated Myelomonocytic Cells Plasticity

Ario Garza en el documento que acredita su maestría En el 81 aniversario del nacimiento de nuestro querido maestro Ario Garza Mercado, iniciamos en su honor la publicación del Blog de la Biblioteca Daniel Cosío Villegas (BDCV) de El Colegio de México (COLMEX), el cual pretende ser un canal de comunicación innovador y participativo, una ventana para que los usuarios reales y potenciales, conozcan nuestros servicios, las colecciones y también para que los Bibliotecólogos Académicos de la BDCV c..

Reciprocal interference between the NRF2 and LPS signaling pathways on the immune-metabolic phenotype of peritoneal macrophages

The metabolic and immune adaptation to extracellular signals allows macrophages to carry out specialized functions involved in immune protection and tissue homeostasis. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that coordinates cell redox and metabolic responses to stressors. However, the individual and concomitant activation of NRF2 and inflammatory pathways have been poorly investigated in isolated macrophages. We here took advantage of reporter mice for the transcriptional activities of NRF2 and nuclear factor-kB (NF\u3baB), a key transcription factor in inflammation, and observe a persisting reciprocal interference in the response of peritoneal macrophages to the respective activators, tert-Butylhydroquinone (tBHQ) and lipopolysaccharide (LPS). When analyzed separately by gene expression studies, these pathways trigger macrophage-specific metabolic and proliferative target genes that are associated with tBHQ-induced pentose phosphate pathway (PPP) with no proliferative response, and with opposite effects observed with LPS. Importantly, the simultaneous administration of tBHQ&nbsp;+&nbsp;LPS alters the effects of each individual pathway in a target gene-specific manner. In fact, this co-treatment potentiates the effects of tBHQ on the antioxidant enzyme, HMOX1, and the antibacterial enzyme, IRG1, respectively; moreover, the combined treatment reduces tBHQ activity on the glycolytic enzymes, TALDO1 and TKT, and decreases LPS effects on the metabolic enzyme IDH1, the proliferation-related proteins KI67 and PPAT, and the inflammatory cytokines IL-1\u3b2, IL-6, and TNF\u3b1. Altogether, our results show that the activation of NRF2 redirects the metabolic, immune, and proliferative response of peritoneal macrophages to inflammatory signals, with relevant consequences for the pharmacological treatment of diseases that are associated with unopposed inflammatory responses