1,064 research outputs found
Free energy of cluster formation and a new scaling relation for the nucleation rate
Recent very large molecular dynamics simulations of homogeneous nucleation
with Lennard-Jones atoms [Diemand et al. J. Chem. Phys. {\bf
139}, 074309 (2013)] allow us to accurately determine the formation free energy
of clusters over a wide range of cluster sizes. This is now possible because
such large simulations allow for very precise measurements of the cluster size
distribution in the steady state nucleation regime. The peaks of the free
energy curves give critical cluster sizes, which agree well with independent
estimates based on the nucleation theorem. Using these results, we derive an
analytical formula and a new scaling relation for nucleation rates: is scaled by , where the supersaturation ratio is ,
is the dimensionless surface energy, and is a dimensionless
nucleation rate. This relation can be derived using the free energy of cluster
formation at equilibrium which corresponds to the surface energy required to
form the vapor-liquid interface. At low temperatures (below the triple point),
we find that the surface energy divided by that of the classical nucleation
theory does not depend on temperature, which leads to the scaling relation and
implies a constant, positive Tolman length equal to half of the mean
inter-particle separation in the liquid phase.Comment: 7 figure
Multiscale expansion of the lattice potential KdV equation on functions of infinite slow-varyness order
We present a discrete multiscale expansion of the lattice potential
Korteweg-de Vries (lpKdV) equation on functions of infinite order of
slow-varyness. To do so we introduce a formal expansion of the shift operator
on many lattices holding at all orders. The lowest secularity condition from
the expansion of the lpKdV equation gives a nonlinear lattice equation,
depending on shifts of all orders, of the form of the nonlinear Schr\"odinger
(NLS) equationComment: 9 pages, submitted to Journ. Phys.
Explicit Form of the Evolution Operator of Tavis-Cummings Model : Three and Four Atoms Cases
In this letter the explicit form of evolution operator of the Tavis-Cummings
model with three and four atoms is given. This is an important progress in
quantum optics or mathematical physics.Comment: Latex file, 10 pages. We combined quant-ph/0404034(the three atoms
case) and quant-ph/0406184(the four atoms case) into an article. to appear in
International Journal of Geometric Methods in Modern Physic
Homogeneity of Stellar Populations in Early-Type Galaxies with Different X-ray Properties
We have found the stellar populations of early-type galaxies are homogeneous
with no significant difference in color or Mg2 index, despite the dichotomy
between X-ray extended early-type galaxies and X-ray compact ones. Since the
X-ray properties reflect the potential gravitational structure and hence the
process of galaxy formation, the homogeneity of the stellar populations implies
that the formation of stars in early-type galaxies predat es the epoch when the
dichotomy of the potential structure was established.Comment: 6 pages, 5 figures, accepted for publication in Ap
Feasibility of adjusting paced left ventricular activation by manipulating stimulus strength
The ALMA Discovery of the Rotating Disk and Fast Outflow of Cold Molecular Gas in NGC 1275
We present ALMA Band 6 observations of the CO(2-1), HCN(3-2), and
HCO(3-2) lines in the nearby radio galaxy / brightest cluster galaxy
(BCG) of NGC 1275 with the spatial resolution of pc. In the previous
observations, CO(2-1) emission was detected as radial filaments lying in the
east-west direction. We resolved the inner filament and found that the filament
cannot be represented by a simple infalling stream both morphologically and
kinematically. The observed complex nature of the filament resembles the cold
gas structure predicted by recent numerical simulations of cold chaotic
accretion. A crude estimate suggests that the accretion rate of the cold gas
can be higher than that of hot gas. Within the central 100 pc, we detected a
rotational disk of the molecular gas whose mass is \sim10^{8} M_{\sun}. This
is the first evidence of the presence of massive cold gas disk on this spatial
scale for BCGs. The disk rotation axis is approximately consistent with the
axis of the radio jet on subpc scales. This probably suggests that the cold gas
disk is physically connected to the innermost accretion disk which is
responsible for jet launching. We also detected absorption features in the
HCN(3-2) and HCO(3-2) spectra against the radio continuum emission mostly
radiated by -pc size jet. The absorption features are blue-shifted
from the systemic velocity by 300-600~km~s, which suggests the
presence of outflowing gas from the active galactic nucleus (AGN). We discuss
the relation of the AGN feeding with cold accretion, the origin of blue-shifted
absorption, and estimate of black hole mass using the molecular gas dynamics.Comment: Version 2 (accepted version). 18 pages, 16 figures. Accepted for
publication in Ap
Rare coding variants in CHRNB2 reduce the likelihood of smoking
Human genetic studies of smoking behavior have been thus far largely limited to common variants. Studying rare coding variants has the potential to identify drug targets. We performed an exome-wide association study of smoking phenotypes in up to 749,459 individuals and discovered a protective association in CHRNB2, encoding the β2 subunit of the α4β2 nicotine acetylcholine receptor. Rare predicted loss-of-function and likely deleterious missense variants in CHRNB2 in aggregate were associated with a 35% decreased odds for smoking heavily (odds ratio (OR) = 0.65, confidence interval (CI) = 0.56–0.76, P = 1.9 × 10−8). An independent common variant association in the protective direction (rs2072659; OR = 0.96; CI = 0.94–0.98; P = 5.3 × 10−6) was also evident, suggesting an allelic series. Our findings in humans align with decades-old experimental observations in mice that β2 loss abolishes nicotine-mediated neuronal responses and attenuates nicotine self-administration. Our genetic discovery will inspire future drug designs targeting CHRNB2 in the brain for the treatment of nicotine addiction
Complete maturation of the plastid protein translocation channel requires a type I signal peptidase
The protein translocation channel at the plastid outer envelope membrane, Toc75, is essential for the viability of plants from the embryonic stage. It is encoded in the nucleus and is synthesized with a bipartite transit peptide that is cleaved during maturation. Despite its important function, the molecular mechanism and the biological significance of the full maturation of Toc75 remain unclear. In this study, we show that a type I signal peptidase (SPase I) is responsible for this process. First, we demonstrate that a bacterial SPase I converted Toc75 precursor to its mature form in vitro. Next, we show that disruption of a gene encoding plastidic SPase I (Plsp1) resulted in the accumulation of immature forms of Toc75, severe reduction of plastid internal membrane development, and a seedling lethal phenotype. These phenotypes were rescued by the overexpression of Plsp1 complementary DNA. Plsp1 appeared to be targeted both to the envelope and to the thylakoidal membranes; thus, it may have multiple functions
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