3 research outputs found

    Manželské mýty

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    Phenotype heritabilities. Figure S2. Miami plot for height. Figure S3. Miami plot for BMI. Figure S4. Miami plot for waist circumference. Figure S5. Miami plot for waist-to-hip ratio. Figure S6. Miami plot for body fat percentage. Figure S7. Miami plot for diastolic blood pressure. Figure S8. Miami plot for creatinine. Figure S9. Miami plot for urea. Figure S10. Miami plot for fasting glucose (all individuals included). Figure S11. Miami plot for fasting glucose (excluding diabetics and measurements of >7 mmol/L). Figure S12. Miami plot for HDL cholesterol. Figure S13. Miami plot for total cholesterol. Figure S14. Miami plot for total cholesterol adjusted for statin use. Figure S15. QQ plots for all traits analysed. Figure S16. Comparison of effect sizes for GUGC top hits in the GS:SFHS EHR analysis. (PDF 2160 kb

    Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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    Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (Phase 1) imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5x10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1, AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered
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