Effects of dietary fibre and the provision of a foraging substrate on the welfare of sows in different grouping systems

End of project reportThere are no clear guidelines on how best to meet the EU legislative requirement (Council Directive 2001/88/EC) that pregnant sows and gilts should be provided with sufficient amounts of bulky or high fibre diets and high energy food to satisfy hunger and the motivation to chew. Therefore the aim of this project was to investigate the effect of increasing dietary fibre levels and providing access to a foraging substrate on the welfare of sows housed in dynamic and static groups. To achieve this a review paper was compiled and three experiments were conducted. The aim of the review paper was to assess the effectiveness of increasing dietary fibre levels on the welfare of pregnant sows. Previous research found that increasing dietary fibre levels decrease activity levels and the performance of stereotypic behaviour, and increase resting behaviour. However, high fibre diets do not appear to reduce aggression between group-housed pregnant sows. The research clearly showed that the effectiveness of high fibre diets is influenced by the source of fibre, with soluble fibres being more effective in reducing stereotypic behaviours than insoluble fibres. However the optimum fibrous ingredient, or combination of ingredients, and the optimum dietary inclusion rate for these ingredients remains unclear

Compression of Martian atmosphere for production of oxygen

The compression of CO2 from the Martian atmosphere for production of O2 via an electrochemical cell is addressed. Design specifications call for an oxygen production rate of 10 kg per day and for compression of 50 times that mass of CO2. Those specifications require a compression rate of over 770 cfm at standard Martian temperature and pressure (SMTP). Much of the CO2 being compressed represents waste, unless it can be recycled. Recycling can reduce the volume of gas that must be compressed to 40 cfm at SMTP. That volume reduction represents significant mass savings in the compressor, heating equipment, filters, and energy source. Successful recycle of the gas requires separation of CO (produced in the electrochemical cell) from CO2, N2, and Ar found in the Martian atmosphere. That aspect was the focus of this work

Hairy Leukoplakia

Oral hairy leukoplakia (OHL) is a disease of the mucosa first described in 1984. This pathology is associated with Epstein-Barr virus (EBV) and occurs mostly in people with HIV infection, both immunocompromised and immunocompetent, and can affect patients who are HIV negative. [1, 2] The first case in an HIV-negative patient was reported in 1999 in a 56-year-old patient with acute lymphocytic leukemia. Later, many cases were reported in heart, kidney, and bone marrow transplant recipients and patients with hematological malignancies. [3, 4

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress

Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium. Their long life, lineage plasticity, and proliferative potential underlie the necessity for tight homeostatic regulation of the ISC compartment. In that context, the guanylate cyclase C (GUCY2C) receptor and its paracrine ligands regulate intestinal epithelial homeostasis, including proliferation, lineage commitment, and DNA damage repair. However, a role for this axis in maintaining ISCs remains unknown. Transgenic mice enabling analysis of ISCs (Lgr5-GFP) in the context of GUCY2C elimination (Gucy2c-/-) were combined with immunodetection techniques and pharmacological treatments to define the role of the GUCY2C signaling axis in supporting ISCs. ISCs were reduced in Gucy2c-/- mice, associated with loss of active Lgr5+ cells but a reciprocal increase in reserve Bmi1+ cells. GUCY2C was expressed in crypt base Lgr5+ cells in which it mediates canonical cyclic (c) GMPdependent signaling. Endoplasmic reticulum (ER) stress, typically absent from ISCs, was elevated throughout the crypt base in Gucy2c-/- mice. The chemical chaperone tauroursodeoxycholic acid resolved this ER stress and restored the balance of ISCs, an effect mimicked by the GUCY2C effector 8Br-cGMP. Reduced ISCs in Gucy2c-/-mice was associated with greater epithelial injury and impaired regeneration following sub-lethal doses of irradiation. These observations suggest that GUCY2C provides homeostatic signals that modulate ER stress and cell vulnerability as part of the machinery contributing to the integrity of ISCs. © Kraft et al

Isospin fractionation and isoscaling in dynamical nuclear collisions

Isoscaling is found to hold for fragment yields in the antisymmetrized molecular dynamics (AMD) simulations for collisions of calcium isotopes at 35 MeV/nucleon. This suggests the applicability of statistical considerations to the dynamical fragment emission. The observed linear relationship between the isoscaling parameters and the isospin asymmetry of fragments supports the above suggestion. The slope of this linear function yields information about the symmetry energy in low density region where multifragmentation occurs.Comment: 11 pages, 6 figure

Extending the theory of Owicki and Gries with a logic of progress

This paper describes a logic of progress for concurrent programs. The logic is based on that of UNITY, molded to fit a sequential programming model. Integration of the two is achieved by using auxiliary variables in a systematic way that incorporates program counters into the program text. The rules for progress in UNITY are then modified to suit this new system. This modification is however subtle enough to allow the theory of Owicki and Gries to be used without change

Self-Pulsating Semiconductor Lasers: Theory and Experiment

We report detailed measurements of the pump-current dependency of the self-pulsating frequency of semiconductor CD lasers. A distinct kink in this dependence is found and explained using rate-equation model. The kink denotes a transition between a region where the self-pulsations are weakly sustained relaxation oscillations and a region where Q-switching takes place. Simulations show that spontaneous emission noise plays a crucial role for the cross-over.Comment: Revtex, 16 pages, 7 figure

The S2 VLBI Correlator: A Correlator for Space VLBI and Geodetic Signal Processing

We describe the design of a correlator system for ground and space-based VLBI. The correlator contains unique signal processing functions: flexible LO frequency switching for bandwidth synthesis; 1 ms dump intervals, multi-rate digital signal-processing techniques to allow correlation of signals at different sample rates; and a digital filter for very high resolution cross-power spectra. It also includes autocorrelation, tone extraction, pulsar gating, signal-statistics accumulation.Comment: 44 pages, 13 figure

Multipayload interferometric wave vector determination of auroral hiss

We extend traditional, single payload, interferometric techniques to a multiple payload sounding rocket mission, and apply these techniques to measure the parallel and perpendicular wavelength of auroral VLF hiss from 8 kHz–20 kHz. We model the wavelength distribution of auroral hiss as a cone at a fixed angle with respect to the magnetic field that is isotropically distributed in the perpendicular plane. We apply this model to calculate the interferometric observables, coherency and phase, for a sounding rocket mission whose wave electric field receivers are on payloads that are separated 2–3 km along the magnetic field and 55–200 m across the magnetic field. Using an interferometer formed by comparing the collinear sphere-to-skin electric field antennas on a single payload, we estimate a lower limit on the perpendicular wavelength of VLF hiss of ∼60 m. Analysis of coherency and phase due to this conical wave vector distribution for a multipayload interferometer reveals the existence of a spin dependent coherency pattern. From this coherency pattern we generate an upper limit perpendicular wavelength estimate for VLF hiss of ∼350 m. The inter-payload phase gives an accurate estimate of the parallel wavelength of ∼6000–8000 m. This parallel wavelength is combined with the lower (upper) limit perpendicular wavelength estimates to generate upper (lower) limits on wave-normal angle. These limits are each within one degree of the predicted electrostatic whistler wave resonance cone angle verifying that VLF hiss propagates on this resonance cone