Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skane study

Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of 2013 at a median age of 5.8 years (0.8-12.2 years). In the multivariate analysis, the presence of IA-2 autoantibodies (IA-2A) in cord blood (HR 6.88, 95% CI 1.46,32.4; p = 0.003), but not maternal diabetes (HR 1.38, 95% CI 0.24,7.84; p = 0.71), was associated with risk of developing type 1 diabetes. No increased risk could be seen for the presence of autoantibodies to GAD65 or insulin. Conclusions/interpretation Our study indicates that the presence of cord blood IA-2A superimposes maternal diabetes and other cord blood islet autoantibodies as a predictor of type 1 diabetes development in the child. These findings may be of significance for future screening and study protocols on type 1 diabetes prediction

Application Lifecycle Management: : En studie av två Application Lifecycle Management system och deras stöd för systemutveckling i projektform

Application Lifecycle Management (ALM) is a genre of computerized systems which allows system development corporations to efficiently and more easily manage, maintain and handle the applications lifecycle. These ALM systems have a wide variety of tools which can be integrated to enable and support collaborative work, while they act at the core of the organisation. Todays ALM systems support flexible system development methods throughout the entire development process. This paper focuses on a case-study of a Swedish business- and technology corporation and their use of two ALM systems with an aim to unravel the differences between these systems and their functionality to serve as a basis for decision making regarding their utilization of best practice with their ALM-Systems. Meanwhile we studied their approach to ALM systems to see if they were using them according to the initial idea of ALM systems. The study is of a qualitative characteristic and both semi-structured interviews with employees and self-gathered data have been used to enable our research and the creation of benchmarks. The results from our study show that the corporation uses both their ALM systems as intended from the initial idea, but we have identified a need to integrate one of the ALM systems with their costumer support portal through a web service. To enable this integration they will raise the amount of affordance to a distinctive degree due to the seamless connection and communication between the ALM system and the customer portal

A model Integrating the Facilities Management Process with the Building End User’s Business Process (ProFacil)

The ProFacil model is a generic process model defined as a framework model showing the links between the facilities management process and the building end user’s business process. The purpose of using the model is to support more detailed process modelling. The model has been developed using the IDEF0 modelling method. The ProFacil model describes business activities from the generalized point of view as management-, support-, and core processes and their relations. The model defines basic activities in the provision of a facility. Examples of these activities are “operate facilities”, “provide new facilities”, “provide re-build facilities”, “provide maintained facilities” and “perform dispose of facilities”. These are all generic activities providing a basis for a further specialisation of company specific FM activities and their tasks. A facilitator can establish a specialized process model using the ProFacil model and interacting with company experts to describe their company’s specific processes. These modelling seminars or interviews will be done in an informal way, supported by the high-level process model as a common reference

Large eddy simulation of unsteady combustion

The present study concerns the application of a large eddy simulation (LES) model, capable of dealing with chemical reactions described by multistep reaction mechanisms and thermal radiation. The LES model, based on prefiltering of the balance equations of mass, momentum, and energy contains a variety of submodels far representing the residual stress tensor and flux vectors and the filtered reaction rates. Here, we have focused on the influence of modeling of the filtered reaction rates. Three different reaction rate formulations have been investigated, the eddy dissipation kinetic model, a model based on the presumed PDF approach, and finally a monotonically integrated LES model that does not explicitly take subgrid scale effects into account. The predictive capabilities of the LES model have been investigated by numerical simulations of the flow past a triangular-shaped flame holder in a rectilinear channel at various operating conditions parameterized by the equivalence ratio, inlet velocity, and temperature. In simulations of reacting flow situations, the fuel was propane and premixed conditions were enforced. Detailed experimental measurements of all operating conditions including temperature probability density functions are available. Comparison of simulated and measured quantities indicates that the LES model is capable of predicting the flow accurately under all three operating conditions and that the movement of the flame front can be captured. Moreover, a discussion describing the dissimilar modes of operation found in the test rig is presented