649 research outputs found

    Volumes that Speak: The Architectural Books of the Drayton Library Catalog and the Design of Drayton Hall

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    Drayton Hall, an early eighteenth-century plantation house on the Ashley River in Charleston, South Carolina, is widely considered to be the first Palladian house in the United States. Now owned and operated by the National Trust for Historic Preservation, Drayton Hall is something of a laboratory for the study of archaeology, landscape architecture, material culture, social history, and historic preservation. Though new discoveries are made almost every day at Drayton Hall, the origins of the house’s design remain unknown. In 2009, the Drayton Library Catalog was discovered within the Drayton manuscript collection containing references to seven popular eighteenth-century architectural books. By comparing measured drawings of Drayton Hall to designs found in these seven books, this project examines the origin of the house’s design in the context of published sources that would have been available at the time of its construction. While some of the books discussed have been previously identified as sources of inspiration, this project led to the discovery of a correlation between a pattern book plate and executed design from one of the seven books in the Drayton Library Catalog. The scope of this project was limited to the seven books in the Catalog and the previously identified sources. For that reason, measured drawings of the interior are included so that this document may be a tool for future studies outside the parameters of this project

    Blackberry Summer

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    A poem about summer

    Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland

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    There is increasing evidence that blood viscosity and its major determinants (haematocrit, plasma viscosity and fibrinogen) are associated with an increased risk of incident cardiovascular events; however, their associations with mortality are not established. We therefore studied the associations of these variables with cardiovascular events and total mortality in 1238 men and women aged 25-64 years, followed for 13 years in the first North Glasgow MONICA (MONItoring CArdiovascular disease) survey and West of Scotland centres in the Scottish Heart Health Study. After adjustment for age and sex, increasing whole blood viscosity, plasma viscosity, haematocrit and fibrinogen (analysed by both von Clauss and heat precipitation assays) were significantly associated with mortality. Only the association for fibrinogen (von Clauss assay) remained significant after adjustment for major cardiovascular risk factors. We conclude that clottable fibrinogen may be independently associated with mortality. However, the significance of this association, and the extent to which viscosity is associated with mortality, remain to be established in larger studies and meta-analyses

    Pigs and Chips:The making of a biotechnology innovation ecosystem

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    This paper presents a longitudinal case study in UK biotechnology covering some 30 years during which genomic technologies were introduced into pig breeding. This case study demonstrates how co-innovation involving existing small and medium sized enterprises, together with contributions from academics, has enabled companies to obtain the resources needed for value creation. Important contributions at critical junctures from public funding, pivotal contributions of individuals, and entry of new enterprises supplying essential resources, have enabled the fruitful realisation of new value creation. This paper contributes to the literature by taking a historical perspective, demonstrating how enabling long-term networking relationships including relevant academics, research institutions, funders and knowledge brokers has the potential to generate an innovation ecosystem that can respond effectively to a range of external challenges and take advantage of new techno-scientific opportunities

    C-reactive protein: associations with haematological variables, cardiovascular risk factors and prevalent cardiovascular disease

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    C-reactive protein (CRP) has been proposed as a risk factor for cardiovascular disease; however, this association is confounded by mutual relationships with both classical and haematological cardiovascular risk factors. We, therefore, measured CRP with a high-sensitivity assay in stored plasma samples from 414 men and 515 women in the north Glasgow MONICA (MONItoring trends in CArdiovascular diseases) survey, to study its correlation with haematological variables, classical risk factors and prevalent cardiovascular disease. CRP correlated with age, oral contraceptive use, menopause and most classical cardiovascular risk factors (except blood pressure). CRP also correlated with plasma levels of the pro-inflammatory cytokine interleukin 6, and haematocrit, viscosity, red cell aggregation, white cell count, and coagulation factors [fibrinogen, factor (F) VII in women, FVIII, FIX] and inhibitors (antithrombin and protein C in women; protein S) but not coagulation activation markers. CRP was significantly associated with prevalent cardiovascular disease in both men (P = 0.03) and women (P = 0.009), however, the association became non-significant after adjustment for firstly classical risk factors, then fibrinogen. We conclude that correlations with classical and haematological risk factors account for a substantial component of the association of CRP with prevalent cardiovascular disease, but there is evidence of a residual, independent effect among women

    The production of anaphoric reference in the written narratives of seven-year-old children: Analyzing the requirements for a computational teaching system based on a psycholinguistic model.

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    This thesis brings together one aspect of language development, the production of anaphoric pronouns in the written narratives of seven-year-old children, with the design of technology appropriate for teaching using whole texts, and pedagogical goals involved in teaching mother-tongue language. A five-stage methodology is proposed for analyzing the requirements for designing a Mother Tongue Language Teaching System (MTLTS) and is used to generate an informal specification of requirements for a prototype system called PROTEUS. PROTEUS is a system for teaching seven-year-old children about the production of pronouns in written narratives. The analysis of requirements includes five stages beginning with the proposal of an adult model of pronoun production having a 'process' orientation. Experimental work is described in which written narratives were elicited and analyzed for the purpose of modelling pronoun production relative to the adult model. A psycholinguistic model of the production of anaphoric reference in the written narratives of seven-year-old children identifies heuristic production strategies which represent a gradual simplification of behavior. These strategies are found to be implemented within local units of text, and range from pronominalization of the only character a local unit of text is about, (by default, pronominalization in clause-initial position), to the emergence of a full-blown position conservation strategy. Children are also found to produce 'pronominal confusion' when they referred to interacting characters in less constrained environments; or, they avoided the use of pronominals altogether. A statement of pedagogical goals for PROTEUS is set out, followed by a review of manual and computational methods for teaching language. Finally, it is concluded that an electronic text should be used to teach about pronominalization, and a system model for PROTEUS, which could be mapped to a system implementation, is proposed

    Partnership Perspectives: Changing the Image of Physical Therapy in Urban Neighborhoods Through Community Service Learning

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    Anecdotally, residents of a local inner-city neighborhood have limited perception and understanding of the physical therapy profession. The purpose of this paper is to present the results of a mixed design pilot study intended to investigate this community\u27s perception of physical therapy and Lower Roxbury community members\u27 assessment of Northeastem University\u27s Department of Physical Therapy community service-learning (CSL) program. Community residents who have been exposed to physical therapy through CSL may have a better understanding and perception of the profession than residents who have not participated
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