Biological variation: back to basics

Biological variation: back to basics

Patient and Sample Identification. out of the Maze?

Background: Patient and sample misidentification may cause significant harm or discomfort to the patients, especially when incorrect data is used for performing specific healthcare activities. It is hence obvious that efficient and quality care can only start from accurate patient identification. There are many opportunities for misidentification in healthcare and laboratory medicine, including homonymy, incorrect patient registration, reliance on wrong patient data, mistakes in order entry, collection of biological specimens from wrong patients, inappropriate sample labeling and inaccurate entry or erroneous transmission of test results through the laboratory information system. Many ongoing efforts are made to prevent this important healthcare problem, entailing streamlined strategies for identifying patients throughout the healthcare industry by means of traditional and innovative identifiers, as well as using technologic tools that may enhance both the quality and efficiency of blood tubes labeling. The aim of this article is to provide an overview about the liability of identification errors in healthcare, thus providing a pragmatic approach for diverging the so-called patient identification crisis

Machine learning in laboratory diagnostics: valuable resources or a big hoax?

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Current Cancer Epidemiology

In this brief report, we offer a concise overview on current cancer epidemiology garnered from the official databases of World Health Organization and American Cancer Society and provide recent information on frequency, mortality, and survival expectancy of the 15 leading types of cancers worldwide. Overall, cancer poses the highest clinical, social, and economic burden in terms of cause-specific Disability-Adjusted Life Years (DALYs) among all human diseases. The overall 0\u201374 years risk of developing cancer is 20.2% (22.4% in men and 18.2% in women, respectively). A total number of 18 million new cases have been diagnosed in 2018, the most frequent of which are lung (2.09 million cases), breast (2.09 million cases), and prostate (1.28 million cases) cancers. Beside sex-specific malignancies, the ratio of frequency between men and women is >1 for all cancers, except thyroid (i.e., 0.30). As concerns mortality, cancer is the second worldwide cause of death (8.97 million deaths) after ischemic heart disease, but will likely become the first in 2060 (~18.63 million deaths). Lung, liver, and stomach are the three most deadly cancers in the general population, while lung and breast cancers are the leading causes of cancer related-mortality in men and women, respectively. Prostate and thyroid cancers have the best prognosis, with 5-year survival ~100%, while esophagus, liver, and especially pancreas cancers have the worst prognosis, typically <20% at 5 years. We hope that this report will provide fertile ground for addressing health-care interventions aimed at preventing, diagnosing, and managing cancer around the world

Hyponatremia and Bone Fractures: An Intriguing and Often Overlooked Association

Hyponatremia and Bone Fractures: An Intriguing and Often Overlooked Associatio

La liaison fructueuse: Laboratory and emergency medicine

La liaison fructueuse: Laboratory and emergency medicin

The risks of defensive (emergency) medicine. The laboratory perspective

Diagnostic testing is a crucial aspect of the clinical decision making, especially in emergency settings where timely and accurate diagnoses are essential for appropriate patient management. Reliable statistics attest that the vast majority of clinical decisions for diagnosis, treatment and follow-up of both acute and chronic diseases are influenced by results of laboratory analyses. As specifically concerns the emergency department, many unnecessary laboratory tests are also ordered in this healthcare setting, with unfavorable consequences on laboratory and healthcare organization. As far as the laboratory environment is concerned, defensive (emergency medicine) may be associated with incremental costs, derangement of laboratory organization, enhanced complexity of data management process, diagnostic delay attributable to performance of unnecessary testing, and litigation. Educative or even regulatory interventions are hence urgently needed to addresses problems of the current liability system, in order to decrease the detrimental effects of defensive (emergency) medicine in the laboratory

Recombinant Factor VIII Concentrates

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Cardiac troponin elevation in patients with influenza virus infections

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