Social structure and diffusion of farm information : based on study of a farm community in Northeast Missouri

Digitized 2007 AES.Includes bibliographical references (pages 106-107)

Adopters of new farm ideas : characteristics and communications behavior (1961)

"IP-15M-10:61-SQ.""Agricultural Extension Services of Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota and Wisconsin.""North central regional extension publication number 13.""Farm Foundation and Federal Extension Service Cooperating.""Subcommittee for the study of diffusion of farm practices.

Diffusion research needs.

Cover title."Agricultural Experiment Stations of Alaska, Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota, Ohio, Wisconsin and the Farm Foundation and Cooperative State Research Service, USDA."Some general problems in diffusion from the perspective of theory of social action / C. Milton Coughenour -- Research needed on adoptive models / Joe M. Bohlen -- Needed research on the structures of interpersonal communications and influence / Herbert F. Lionberger -- A communications research approach to the diffusion of innovations / Everett M. Rogers.Includes bibliographical references

Quality by Design: Concepts for ANDAs

Quality by design is an essential part of the modern approach to pharmaceutical quality. There is much confusion among pharmaceutical scientists in generic drug industry about the appropriate element and terminology of quality by design. This paper discusses quality by design for generic drugs and presents a summary of the key terminology. The elements of quality by design are examined and a consistent nomenclature for quality by design, critical quality attribute, critical process parameter, critical material attribute, and control strategy is proposed. Agreement on these key concepts will allow discussion of the application of these concepts to abbreviated new drug applications to progress

Structural diversity of supercoiled DNA

By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA, in particular) remains unknown. Here we use electron cryo-tomography together with biochemical analyses to investigate structures of individual purified DNA min icircle topoisomers with defined degrees of supercoiling. Our results reveal that each topoisomer, negative or positive, adopts a unique and surprisingly wide distribution of three-dimensional conformations. Moreover, we uncover striking differences in how the topoisomers handle torsional stress. As negative supercoiling increases, bases are increasingly exposed. Beyond a sharp supercoiling threshold, we also detect exposed bases in positively supercoiled DNA. Molecular dynamics simulations independently confirm the conformational heterogeneity and provide atomistic insight into the flexibility of supercoiled DNA. Our integrated approach reveals the three-dimensional structures of DNA that are essential for its function