10 research outputs found
An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE):A Phase Ib/IIa Randomised Controlled Trial
RATIONALE: High circulating galectin-3 is associated with poor outcomes in patients with coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled thiodigalactoside galectin-3 inhibitor with antiinflammatory and antifibrotic actions, would be safely and effectively delivered in COVID-19 pneumonitis. OBJECTIVES: Primary outcomes were safety and tolerability of inhaled GB0139 as an add-on therapy for patients hospitalized with COVID-19 pneumonitis. METHODS: We present the findings of two arms of a phase Ib/IIa randomized controlled platform trial in hospitalized patients with confirmed COVID-19 pneumonitis. Patients received standard of care (SoC) or SoC plus 10 mg inhaled GB0139 twice daily for 48 hours, then once daily for up to 14 days or discharge. MEASUREMENTS AND MAIN RESULTS: Data are reported from 41 patients, 20 of which were assigned randomly to receive GB0139. Primary outcomes: the GB0139 group experienced no treatment-related serious adverse events. Incidences of adverse events were similar between treatment arms (40 with GB0139â+âSoC vs. 35 with SoC). Secondary outcomes: plasma GB0139 was measurable in all patients after inhaled exposure and demonstrated target engagement with decreased circulating galectin (overall treatment effect post-hoc analysis of covariance [ANCOVA] over days 2â7; Pâ=â0.0099 vs. SoC). Plasma biomarkers associated with inflammation, fibrosis, coagulopathy, and major organ function were evaluated. CONCLUSIONS: In COVID-19 pneumonitis, inhaled GB0139 was well-tolerated and achieved clinically relevant plasma concentrations with target engagement. The data support larger clinical trials to determine clinical efficacy. Clinical trial registered with ClinicalTrials.gov (NCT04473053) and EudraCT (2020â002230â32)
Normkreativ kyrka : Ett examensarbete om visuell kommunikation i den kristna kyrkan
Den kristna traditionen aÌr djupt rotad i vaÌrt samhaÌlle. Kristna hoÌgtider aÌr allmaÌnna helgdagar och vigslar, dop och begravningar i kyrkan tillhoÌr det vanliga. Trots detta aÌr Sverige idag ett av vaÌrldens mest sekulariserade laÌnder och bara 10% av svenskar menar att religion spelar en viktig roll i deras liv. Medlemsantalet och antalet gudstjaÌnstbesoÌkare i Svenska kyrkan sjunker foÌr varje aÌr. MaÌlet med detta arbete aÌr att visa paÌ hur visuell kommunikation kan anvaÌndas foÌr att foÌraÌndra foÌrutfattade meningar om kristendomen och bygga broar mellan aÌsikter och ideologier. I Normkreativ kyrka tar jag avstamp i den klassiska kristna bildkonsten foÌr att skapa en ny upplevelse av vaÌlbekanta bibliska motiv. PaÌ saÌ saÌtt vill jag skapa foÌrstaÌelse foÌr min personliga trosuppfattning och visa paÌ hur kristendomen kan goÌras relevant i Sverige idag
Technology â is there intentional work with technology? : A survey of pedagogues work with technology in elementary school, preschool to fifth grade.
The purpose of this degree project is to study if there is a intentional work with technology in the elementary school, preschool to fifth grade, in a municipality. The work will also study what conditions there are in the schools in order to work with technology. 95 questionnaires were distributed to the responsible teachers in all primary schools in the municipality, from preschool to fifth grade. The results of the survey show that more than half of the respondents do not consider themselves to work with technology in the school. The conditions, in order to work with the school subject technology in the municipality, are primarily external such as: material, facilities and the ability to divide students into smaller groups. The primary school teachers are experiencing a lack of knowledge within the subject technology and primarily desire further education to be able to work more with technology. One conclusion that emerged in the survey is that technology is a subject with low priority mainly because of lack of knowledge and competence among the teachers.Syftet med examensarbetet Àr att studera om det pÄ ett medvetet sÀtt arbetas med teknik i grundskolan, Är F-5 i en kommun. Arbetet ska Àven studera vilka förutsÀttningar det finns pÄ skolorna för att arbeta med teknik. 95 enkÀter delades ut till ansvariga klasslÀrare pÄ samtliga grundskolor i kommunen med Älderspannet F-5. Resultatet av undersökningen visar att mer Àn hÀlften av de svarande lÀrarna inte anser sig arbeta medvetet med teknik i skolan. De förutsÀttningar som finns för att arbeta med skolÀmnet teknik i kommunen Àr frÀmst yttre förutsÀttningar, dvs. material, lokaler och möjlighet att dela in eleverna i smÄgrupper. LÀrarna upplever en brist pÄ kunskap inom teknikÀmnet och önskar frÀmst fortbildning och kunskap för att kunna arbeta mer med teknik. En slutsats som framkommit i undersökningen Àr att teknik Àr ett lÄgt prioriterat Àmne frÀmst pÄ grund av bristen pÄ kunskap och kompetens hos lÀrarna
The feasibility of face scanning as an age verification tool from a technical- and UX-perspective
Within technical retail solutions, such as self-checkouts, Click & Collect boxes, and vending machines, there is always an ongoing process to find ways to make them as self-sufficient as possible. One occasion where personnel is still needed is when an age control for age-restricted products needs to be done. In this thesis work the possibilities to use face scanning as an age verification tool is investigated. The age estimation used by the examined software is powered by an AI that performs the age estimation based on a face scan of the person in front of the camera. It is the user experience, as well as the accuracy of the age estimation, that is being analysed. The study was done with quantitative research that included literature studies and a user test together with a survey. There were a total of 100 participants in the user test and 89 in the survey. From the results in this paper, the conclusion is that the age estimation is not yet accurate enough to be used in real-life situations, at least not without a high age buffer. The user experience was perceived as good and indicated that a solution like this would be approved and used by the approaching crowd. Inom tekniska lösningar i detaljhandeln, sĂ„som sjĂ€lvutcheckningskassor, Click & Collect boxar samt varuautomater, sĂ„ finns det en stĂ€ndigt pĂ„gĂ„ende process för att hitta sĂ€tt att göra lösningarna sĂ„ sjĂ€lvgĂ„ende som möjligt. Ett tillfĂ€lle dĂ€r personal fortfarande behövs Ă€r nĂ€r en Ă„lderskontroll för Ă„ldersbegrĂ€nsade produkter behöver utföras. I detta examensarbete undersöks möjligheterna att anvĂ€nda ansiktsskanning som ett verktyg för Ă„ldersverifiering. Ă
ldersestimationen som anvÀnds av den undersökta programvaran drivs av en AI som utför Äldersestimering baserat pÄ en ansiktsskanning av personen framför kameran. Det Àr anvÀndarupplevelsen, sÄvÀl som noggrannheten i Äldersestimeringen, som har analyserats. Studien utfördes som en kvantitativ forskning som innefattade en litteraturstudier samt ett anvÀndartest med en tillhörande enkÀt.  Det var totalt 100 deltagare i anvÀndartestet och 89 i undersökningen. FrÄn resultaten i denna rapport Àr slutsatsen att Äldersestimationen Ànnu inte Àr tillrÀckligt trÀffsÀker för att kunna anvÀndas i verkliga situationer, Ätminstone inte utan en hög Äldersbuffert. AnvÀndarupplevelsen upplevdes som bra och indikerade att en lösning som denna skulle godkÀnnas och anvÀndas av mÄlgruppen i frÄga
The feasibility of face scanning as an age verification tool from a technical- and UX-perspective
Within technical retail solutions, such as self-checkouts, Click & Collect boxes, and vending machines, there is always an ongoing process to find ways to make them as self-sufficient as possible. One occasion where personnel is still needed is when an age control for age-restricted products needs to be done. In this thesis work the possibilities to use face scanning as an age verification tool is investigated. The age estimation used by the examined software is powered by an AI that performs the age estimation based on a face scan of the person in front of the camera. It is the user experience, as well as the accuracy of the age estimation, that is being analysed. The study was done with quantitative research that included literature studies and a user test together with a survey. There were a total of 100 participants in the user test and 89 in the survey. From the results in this paper, the conclusion is that the age estimation is not yet accurate enough to be used in real-life situations, at least not without a high age buffer. The user experience was perceived as good and indicated that a solution like this would be approved and used by the approaching crowd. Inom tekniska lösningar i detaljhandeln, sĂ„som sjĂ€lvutcheckningskassor, Click & Collect boxar samt varuautomater, sĂ„ finns det en stĂ€ndigt pĂ„gĂ„ende process för att hitta sĂ€tt att göra lösningarna sĂ„ sjĂ€lvgĂ„ende som möjligt. Ett tillfĂ€lle dĂ€r personal fortfarande behövs Ă€r nĂ€r en Ă„lderskontroll för Ă„ldersbegrĂ€nsade produkter behöver utföras. I detta examensarbete undersöks möjligheterna att anvĂ€nda ansiktsskanning som ett verktyg för Ă„ldersverifiering. Ă
ldersestimationen som anvÀnds av den undersökta programvaran drivs av en AI som utför Äldersestimering baserat pÄ en ansiktsskanning av personen framför kameran. Det Àr anvÀndarupplevelsen, sÄvÀl som noggrannheten i Äldersestimeringen, som har analyserats. Studien utfördes som en kvantitativ forskning som innefattade en litteraturstudier samt ett anvÀndartest med en tillhörande enkÀt.  Det var totalt 100 deltagare i anvÀndartestet och 89 i undersökningen. FrÄn resultaten i denna rapport Àr slutsatsen att Äldersestimationen Ànnu inte Àr tillrÀckligt trÀffsÀker för att kunna anvÀndas i verkliga situationer, Ätminstone inte utan en hög Äldersbuffert. AnvÀndarupplevelsen upplevdes som bra och indikerade att en lösning som denna skulle godkÀnnas och anvÀndas av mÄlgruppen i frÄga
The influence of online consumer reviews on consumer buying behavior in the buying process : With a focus on high and low involvement products
Validerat; 20150114 (global_studentproject_submitter
Ăr varumĂ€rken de nya politikerna? : En kvalitativ studie om olika generationers upplevelse av brand activism i förpackningsdesign
This study investigates how different generations interpret the marketing strategy of brand activism through packaging design. This marketing strategy is a relatively new one, and refers to corporations that engage and take stances in current political causes. As it is a fairly unexplored area of research, the purpose of this study is to look further into the attitudes towards brand activism among different generations, and explore if it has an impact on their purchase intentions. Four different generations have been selected for this research project, namely; Baby Boomers, generation X, Y and Z. A qualitative method in terms of semi-structured interviews has been chosen, and four respondents from each generation have participated. The sixteen respondents have been selected through a goal-oriented convenience sample, and the interviews have been conducted both physically and digitally. In the interviews, respondents have analyzed the packages of Ben & Jerry's, Tony's Chocolonely and Oatly, three brands who are all using the marketing strategy of brand activism, and are mediating this through their packaging designs. This study accounts for brand activism and its development, and presents both successful and disadvantageous examples of businesses using brand activism. Furthermore the study explains the important role of the package as a bearer of a brand, and how it can affect the purchase behaviour of consumers. To get a deeper understanding about why the aspect of generations is examined in this study, previous research is presented to highlight its importance of showing various purchase behaviour. The research area discusses how corporations should take part or not in social responsibility to create a greater comprehension about brand activism. A discussion about whether brand activism is perceived as authentic has also been taken into consideration. To investigate these questions and to explore the research area, Generation Cohort Theory, The ABC-model, Brand Authenticity and Kotler's communication process, have been chosen as the theoretical framework. These theories and models have been put into a modification of Kotler's communication process, to bring distinctness to the studies subject area. The results show that every generation has thoughts and attitudes towards the area, and there is a twofold attitude towards brand activism. Some conclusions based on the collected empirical data can be drawn. None of the respondents, regardless of generation, have paid attention to the activistic message in the packaging design. Additionally every generation points out that brand activism does not affect their purchase intention in greater occurrence, but it might have an influence in a buying situation between two equivalent products. The empirical data also shows that the younger generations have a great knowledge about the brands and brand activism, and consume the products more frequently than the older generations. Finally, the study has shown that authenticity plays a significant role in this regard
Beaconlogin - an Efficient Way to Register Presence on Construction Sites
As of January the first, 2016, all companies working in the Swedish construction industry must follow a new law. The law makes it mandatory for anyone carrying out construction activities to have electronic staff registers on their sites. Failing to present a correct registration of all personnel present at the construction site will result in a fine ranging from 15,000 SEK to 25,000 SEK. Our solution for a simple way of registration builds on Bluetooth technology combined with a smartphone application. Together with Bluetooth devices, the registration can be done automatically which eliminates the need for construction workers to actively search for the e-staff register.Den första januari 2016 infördes en ny lag för företag inom den Svenska byggarbetsbranchen som gör det obligatoriskt för alla som utför byggverksamhet att ha elektroniska personalliggare pÄ sina byggarbetsplatser. Om man inte kan visa upp en korrekt nÀrvaroregistrering av den personal som befinner sig pÄ byggarbetsplatsen riskerar man som företag böter pÄ mellan 15 000 SEK till 25 000 SEK. VÄr lösning för att sköta nÀrvaroregistrering bygger pÄ bluetoothteknologi i kombination med en mobilapplikation. Med hjÀlp av bluetoothenheter kan registreringen ske automatiskt vilket tar bort behovet för arbetare att aktivt sjÀlva behöva sköta sin registrering
Beaconlogin - an Efficient Way to Register Presence on Construction Sites
As of January the first, 2016, all companies working in the Swedish construction industry must follow a new law. The law makes it mandatory for anyone carrying out construction activities to have electronic staff registers on their sites. Failing to present a correct registration of all personnel present at the construction site will result in a fine ranging from 15,000 SEK to 25,000 SEK. Our solution for a simple way of registration builds on Bluetooth technology combined with a smartphone application. Together with Bluetooth devices, the registration can be done automatically which eliminates the need for construction workers to actively search for the e-staff register.Den första januari 2016 infördes en ny lag för företag inom den Svenska byggarbetsbranchen som gör det obligatoriskt för alla som utför byggverksamhet att ha elektroniska personalliggare pÄ sina byggarbetsplatser. Om man inte kan visa upp en korrekt nÀrvaroregistrering av den personal som befinner sig pÄ byggarbetsplatsen riskerar man som företag böter pÄ mellan 15 000 SEK till 25 000 SEK. VÄr lösning för att sköta nÀrvaroregistrering bygger pÄ bluetoothteknologi i kombination med en mobilapplikation. Med hjÀlp av bluetoothenheter kan registreringen ske automatiskt vilket tar bort behovet för arbetare att aktivt sjÀlva behöva sköta sin registrering
Beaconlogin - an Efficient Way to Register Presence on Construction Sites
As of January the first, 2016, all companies working in the Swedish construction industry must follow a new law. The law makes it mandatory for anyone carrying out construction activities to have electronic staff registers on their sites. Failing to present a correct registration of all personnel present at the construction site will result in a fine ranging from 15,000 SEK to 25,000 SEK. Our solution for a simple way of registration builds on Bluetooth technology combined with a smartphone application. Together with Bluetooth devices, the registration can be done automatically which eliminates the need for construction workers to actively search for the e-staff register.Den första januari 2016 infördes en ny lag för företag inom den Svenska byggarbetsbranchen som gör det obligatoriskt för alla som utför byggverksamhet att ha elektroniska personalliggare pÄ sina byggarbetsplatser. Om man inte kan visa upp en korrekt nÀrvaroregistrering av den personal som befinner sig pÄ byggarbetsplatsen riskerar man som företag böter pÄ mellan 15 000 SEK till 25 000 SEK. VÄr lösning för att sköta nÀrvaroregistrering bygger pÄ bluetoothteknologi i kombination med en mobilapplikation. Med hjÀlp av bluetoothenheter kan registreringen ske automatiskt vilket tar bort behovet för arbetare att aktivt sjÀlva behöva sköta sin registrering