2,992 research outputs found
Higher Education Leaders’ Perceptions on the Angry Black Woman Syndrome
Capturing the voices of Black women on their experiences leading to senior-level leadership positions in higher education warranted research. University leaders must ensure that units implement fair and equitable hiring practices to promote diversity and leadership from all backgrounds. Therefore, this study intended to take an in-depth look into Black women\u27s trajectory in higher education. For this study, the researcher proposed interviewing Black women who have acquired senior-level leadership positions in higher education. The senior-level leadership positions included deans of student affairs, vice presidents of enrollment management, vice presidents of student affairs, college or university presidents, and other senior leadership roles that tend to be commonly filled by White men or women
Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA). Phosphorylation of spinophilin was stimulated by treatment of neostriatal neurons with a dopamine D1 receptor agonist or with forskolin, consistent with spinophilin being a substrate for PKA in intact cells. Using tryptic phosphopeptide mapping, site-directed mutagenesis, and microsequencing analysis, we identified two major sites of phosphorylation, Ser-94 and Ser-177, that are located within the actin-binding domain of spinophilin. Phosphorylation of spinophilin by PKA modulated the association between spinophilin and the actin cytoskeleton. Following subcellular fractionation, unphosphorylated spinophilin was enriched in the postsynaptic density, whereas a pool of phosphorylated spinophilin was found in the cytosol. F-actin co-sedimentation and overlay analysis revealed that phosphorylation of spinophilin reduced the stoichiometry of the spinophilin-actin interaction. In contrast, the ability of spinophilin to bind to PP1 remained unchanged. Taken together, our studies suggest that phosphorylation of spinophilin by PKA modulates the anchoring of the spinophilin-PP1 complex within dendritic spines, thereby likely contributing to the efficacy and plasticity of synaptic transmission
Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis
The clinical presentation of noncystic fibrosis bronchiectasis may be complicated by concomitant conditions, including gastro-oesophageal reflux (GOR). Increased acidic GOR is principally caused by gastro-oesophageal junction incompetence and may arise from lower oesophageal sphincter hypotension, including transient relaxations, hiatus hernia, and oesophageal dysmotility. Specific pathophysiological features which are characteristic of respiratory diseases including coughing may further increase the risk of GOR in bronchiectasis. Reflux may impact on lung disease severity by two mechanisms, reflex bronchoconstriction and pulmonary microaspiration. Symptomatic and clinically silent reflux has been detected in bronchiectasis, with the prevalence of 26 to 75%. The cause and effect relationship has not been established, but preliminary reports suggest that GOR may influence the severity of bronchiectasis. Further studies examining the implications of GOR in this condition, including its effect across the disease spectrum using a combination of diagnostic tools, will clarify the clinical significance of this comorbidity
Photoluminescence in mammal fur: 111 years of research
Photoluminescence in the pelage of mammals, a topic that has gained considerable recent research interest, was first documented in the 1700s and reported sporadically in the literature over the last century. The first detailed species accounts were of rabbits and humans, published 111 years ago in 1911. Recent studies have largely overlooked this earlier research into photoluminescent mammalian taxa and their luminophores. Here we provide a comprehensive update on existing research on photoluminescence in mammal fur, with the intention of drawing attention to earlier pioneering research in this field. We provide an overview on appropriate terminology, explain the physics of photoluminescence, and explore pigmentation and the ubiquitous photoluminescence of animal tissues, before touching on the emerging debate regarding visual function. We then provide a chronological account of research into mammalian fur photoluminescence, from the earliest discoveries and identification of luminophores to the most recent studies. While all mammal fur is likely to have a general low-level photoluminescence due to the presence of the protein keratin, fur glows luminously under ultraviolet light if it contains significant concentrations of tryptophan metabolites or porphyrins. Finally, we briefly discuss issues associated with preserved museum specimens in studies of photoluminescence. The study of mammal fur photoluminescence has a substantial history, which provides a broad foundation on which future studies can be grounded
Role of International Medical Graduates in Kentucky Medicine: Implications For Workforce Planning and Medical Education
An argument for International Medical Graduates (IMGs) as part of a state’s physician workforce is that they “fill the gap” created by the shortage of United States Medical Graduates (USMGs) required to meet the demand for physician services, especially primary care physicians in rural areas.
The purpose of this study is to examine the overall impact of IMGs on Kentucky’s physician workforce and determine whether they overcome the shortage of USMGs. Information from the Kentucky Board of Medical Licensure (KBML) was used to examine the distribution and practice patterns of IMGs and USMGs. IMGs are similar to USMGs in terms of gender, age, and average hours worked. IMGs were not any more likely than USMGs to practice in a primary care specialty. They were more likely to practice in a rural county and a county with a critical access hospital.
In conclusion, IMGs do not completely “fill the gap” in physician shortages in most Kentucky counties. More programs to attract and retain physicians should be developed, especially in rural areas. Additional residency programs at regional medical centers is one recommendation to accomplish this
Quantitative Evaluation of Heavy Metals in the Mastodon Tusk Ivory by Atomic Absorption Spectroscopy
One of the most important objects in the University of Northern Iowa Museum collection is the Mammut Americanum (American Mastodon) tusk, which was originally found in 1933 in a sand pit south of Hampton, Iowa. Since then, severe mechanical and chemical damage was done to the tusk in attempts of restoration and storage, as shown in Figure 1. In order to address these problems, the UNI Museum was awarded a Roy J. Carver Charitable Trust Grant to restore and preserve the American Mastodon tusk. The purpose of the project is quantitative determination of the heavy metal content in the core of the tusk ivory by atomic absorption spectroscopy. Information about trace heavy metals found in mastodon ivory, will help to draw conclusions about the dietary habits and the environment of the mastodon. In addition, since heavy metals are toxic even low concentrations, the content of the heavy metals in ivory is needed to be known, in order to avoid the hazard of heavy metal poisoning for the scientists working on further restoration of the tusk.https://scholarworks.uni.edu/mastodon_posters/1000/thumbnail.jp
KONSTRUKCIJA I MEHANIČKA CJELOVITOST BUŠOTINA ZA UTISKIVANJE CO2
Geologic Sequestration (GS) is part of a process known as “carbon
capture and storage (CCS)” and represents the process of injecting
CO2, into deep subsurface rock formations for long-term storage. For
injecting of CO2 existing wells are used as well as new drilled wells. A
well represents the most likely route for leakage of CO2 from geologic
carbon sequestration. Maintaining mechanical integrity helps prevent
the well and wellbore from becoming conduits for CO2 migration out
of the injection zone. The typical components of a CO2 injection well
are casing, tubing, cement, and packer. These components are relevant
for maintaining mechanical integrity and ensuring CO2 does not migrate
upwards from the injection zone into underground source of drinking
water (USDW); therefore helping to ensure zonal isolation of the
injected carbon dioxide. In order to have the safe underground storage
of CO2 well integrity considerations should be present during all phases
of well life including design phase, drilling, completion, injection,
workover (service) and abandonment.
The paper describes well design, well integrity and mechanical
integrity tests (MITs) as a means of measuring the adequacy of the
construction of the injection well and as a way to detect problems within
the well system.Geološko skladištenje (GS) kao dio procesa “kaptiranje i
skladištenje ugljičnog dioksida (CS)” predstavlja proces utiskivanja
CO2 u duboko zaliježuće stijene radi trajnog skladištenja. U tu svrhu
koriste se postojeće bušotine, ali se izrađuju i nove bušotine. Bušotina
predstavlja najvjerojatniji put za migraciju CO2 iz stijena u kojima je
on uskladišten. Održavanjem mehaničkog integriteta bušotine onemogućava
se da bušotina i njen prstenasti prostor postanu putovi migracije
CO2 iz utisne zone prema površini. Osnovne komponente bušotine za
utiskivanje CO2 su: kolona zaštitnih cijevi, tubing, cementni kamen i
paker. Ove komponente su bitne za održavanje mehaničkog integriteta i
sprječavanje vertikalne migracije CO2 iz utisne zone u stijene koje sadrže
pitku vodu (USDW) jer pomažu da se izolira zona (naslage stijena) u
koju je ugljični dioksid utisnut. Radi postizanja sigurnog uskladištenja
CO2 u podzemlju, integritet bušotine treba sagledati tijekom svih faza u
radnom vijeku bušotine od planiranja, preko bušenja, opremanja, utiskivanja,
održavanja (remonta) sve do trajnog napuštanja bušotine.
U radu se opisuju konstrukcija utisne bušotine, cjelovitost bušotine
te navode testovi mehaničkog integriteta (MITs) kojima se određuje da
li je primijenjena odgovarajuća konstrukcija utisne bušotine i otkrivaju
problemi unutar kanala bušotine
Inclusive teaching circles : mechanisms for creating welcoming classrooms.
This essay examines the Inclusive Teaching Circle (ITC) as a mechanism for faculty development in creating instructional tools that embrace an inclusive pedagogy reflecting diversity, cultural competence and social justice. We describe one group’s year-long participation in an ITC at a large, metropolitan research university in the south. Next, we share several members’ strategies for promoting more inclusive and equitable learning for students in our classrooms. Finally, we consider the implications of ITCs for its group participants and the professorate at large
Greek Oregano—A Niche Crop for Iowa?
The project was the result of a discussion with an Iowa-based company specializing in allnatural health care products for livestock and companion animals. They are interested in finding local sources of oregano oil because they currently import more than 8,000 lb annually from a European supplier. Greek oregano oil is used in animal care products and other pharmaceuticalsfor its carvacrol content, which has shown to have antimicrobial properties. Their product specifications require oil that contains a minimum of 65% carvacrol and 3% thymol
Relationship of electronic nose analyses and sensory evaluation of vegetable oils during storage
Off-flavors associated with oxidized oils make it difficult to recruit sensory panelists to evaluate the oils. Using an instrument called the “electronic nose” to monitor the formation of volatile compounds associated with off-flavors could help to interpret oil oxidation studies in part to supplement human sensory panels. No published studies evaluate the correlation of oil oxidation sensory data and “electronic nose” analyses. Therefore, this project was designed to determine the correlation between sensory evaluation and “electronic nose” analyses. Canola, corn, and soybean oils were stored at 60°C in the dark until sufficiently oxidized. On days 0, 3, 6, 9, and 12, oils were evaluated for peroxide value, for volatile compounds by “electronic nose,” and for off-flavor by sensory evaluation. The results suggest that the “electronic nose” is capable of measuring changes in volatile compounds associated with oil oxidation and could be used to supplement data obtained from sensory evaluations
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