The value of Tc-99m (V) dimercaptosuccinic acid in detecting intra-abdominal infection: compared with gallium scan

Objective Gallium-67 (Ga-67) and labeled leukocytes are useful in the detection of an unknown infectious source. However, the delay in the diagnosis of a Ga-67 citrate scan (gallium scan) and the complicated labeling technique of a leukocyte scan are major drawbacks to their clinical use. Recently, Tc-99m (V) dimercaptosuccinic acid (DMSA) has been found to be very useful in the detection of infection. Tc-99m (V) DMSA is inexpensive, easy to prepare. and provides a result within hours. In this study. we evaluated the potential of Tc-99m (V) DMSA scan (DMSA scan) in the detection of intra-abdominal infection. Methods A total of 33 patients who suffered from an unknown cause of fever after colorectal surgery were enrolled in this study. All patients received both a gallium scan and a DMSA scan. DMSA scintigraphy was performed 3-4 h after an injection of 740 MBq (20 m Ci) of Tc-99m DMSA. After completion of the DMSA image, 111 M Bq (3 mCi) of Ga-67 citrate was injected intravenously. Gallium scintigraphy was performed after 24 h and later as needed. Results Of the 33 patients, 17 (51.5%) were diagnosed with intra-abdominal abscesses. For DMSA scans, the sensitivity, specificity, and overall accuracy were 88.2%, 93.7%, and 90.9%, respectively. For gallium scans, the diagnostic sensitivity, specificity, and accuracy were 100%, 87.5%, and 93.9%, respectively. No statistical difference was found in the diagnostic accuracy between these two diagnostic modalities using Fisher's exact test. Conclusions DMSA scan is a useful alternative to gallium scan in the detection of intra-abdominal infection in patients with colorectal surgery because Tc-99m DMSA is inexpensive, easy to prepare, and most importantly the result can be obtained within hours

Bubbling 1/4 BPS solutions in type IIB and supergravity reductions on S^n x S^n

We extend the construction of bubbling 1/2 BPS solutions of Lin, Lunin and Maldacena (hep-th/0409174) in two directions. First we enquire whether bubbling 1/2 BPS solutions can be constructed in minimal 6d supergravity and second we construct solutions that are 1/4 BPS in type IIB. We find that the S^1 x S^1 bosonic reduction of (1,0) 6d supergravity to 4d gravity coupled to 2 scalars and a gauge field is consistent only provided that the gauge field obeys a constraint (F \wedge F=0). This is to be contrasted to the case of the S^3 x S^3 bosonic reduction of type IIB supergravity to 4d gravity, 2 scalars and a gauge field, where consistency is achieved without imposing any such constraints. Therefore, in the case of (1,0) 6d supergravity we are able to construct 1/2 BPS solutions, similar to those derived in type IIB, provided that this additional constraint is satisfied. This ultimately prohibits the construction of a family of 1/2 BPS solutions corresponding to a bubbling AdS_3 x S^3 geometry. Returning to type IIB solutions, by turning on an axion-dilaton field we construct a family of bubbling 1/4 BPS solutions. This corresponds to the inclusion of back-reacted D7 branes to the solutions of Lin, Lunin and Maldacena.Comment: 30 pages, Latex citations adde

Phylogenetic analysis and biochemical characterization of a thermostable dihydropyrimidinase from alkaliphilic Bacillus sp TS-23

Two degenerate primers established from the alignment of highly conserved amino acid sequences of bacterial dihydropyrimidinases (DHPs) were used to amplify a 330-bp gene fragment from the genomic DNA of Bacillus sp. TS-23 and the amplified DNA was successfully used as a probe to clone a dhp gene from the strain. The open reading frame of the gene consisted of 1422 bp and was deduced to contain 472 amino acids with a molecular mass of 52 kDa. The deduced amino acid sequence exhibited greater than 45% identity with that of prokaryotic D-hydantoinases and eukaryotic DHPs. Phylogenetic analysis showed that Bacillus sp. TS-23 DHP is grouped together with Bacillus stearothermophilus D-hydantoinase and related to dihydroorotases and allantoinases from various organisms. His(6)-tagged DHP was over-expressed in Escherichia coli and purified by immobilized metal affinity chromatography to a specific activity of 3.46 U mg(-1) protein. The optimal pH and temperature for the purified enzyme were 8.0 and 60 degrees C, respectively. The half-life of His(6)-tagged DHP was 25 days at 50 degrees C. The enzyme activity was stimulated by Co2+ and Mn2+ ions. His(6)-tagged DHP was most active toward dihydrouracil followed by hydantoin derivatives. The catalytic efficiencies (k(cat)/K-m) of the enzyme for dihydrouracil and hydantoin were 2.58 and 0.61 s(-1) mM(-1), respectively

The Role of the Fabrication of Anatase-TiO2 Chain-Networked Photoanodes

A novel, sandwich-layered Ti/TiO2/Ti/fluorine-doped tin oxide (FTO) architecture is reported. The Ti layers play a critical role in the formation of long pear-necklace chains made of interconnected TiO2 nanoparticles. The chains interpenetrate a network structure on FTO glass substrates under alkaline hydrothermal-processing conditions. A significant enhancement in the photocurrent density of dye-sensitized solar cells employing non-volatile polymer-based electrolytes is obtained

Harmonic maps from degenerating Riemann surfaces

We study harmonic maps from degenerating Riemann surfaces with uniformly bounded energy and show the so-called generalized energy identity. We find conditions that are both necessary and sufficient for the compactness in $W^{1,2}$ and $C^{0}$ modulo bubbles of sequences of such maps.Comment: 27 page

Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk

Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor alpha (ER alpha) gene polymorphisms were associated with POP risk by conducting a case-control association study in 88 women with POP and 153 women without POP. Genotypes of the ER alpha (ESR1) gene polymorphisms (rs17847075, rs2207647, rs2234693, rs3798577, and rs2228480) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the ESR1 rs2228480 genotypes evaluated. By using multivariable logistic regression, age and ESR1 rs2228480 genotype GA were significantly associated with POP risk. Although the sample size of women with POP studied is small, the present study shows that ER alpha genotype may be associated with POP risk

T-duality and Generalized Kahler Geometry

We use newly discovered N = (2, 2) vector multiplets to clarify T-dualities for generalized Kahler geometries. Following the usual procedure, we gauge isometries of nonlinear sigma-models and introduce Lagrange multipliers that constrain the field-strengths of the gauge fields to vanish. Integrating out the Lagrange multipliers leads to the original action, whereas integrating out the vector multiplets gives the dual action. The description is given both in N = (2, 2) and N = (1, 1) superspace.Comment: 14 pages; published version: some conventions improved, minor clarification