Integration of ceramic membrane through 3D printing technology

In this paper, 3D printing technology was being presented for its compatibility with ceramic materials due to its competitive process in terms of cost and speed, especially for the small quantities production. There were four types of ceramic membrane samples used in this study, which differ in their powder particle sizes and membrane shapes. They were 72μ without hole (1a), 72μ with hole (1b), 133μ without hole (2a), and 133μ with hole (2b). This paper presents the research effort that focuses on integration of ceramic powder with 3D printing technology in order to produce an effective ceramic membrane and characterize them on its physical, structural, and functional properties. Sample 1 has small particle size that results in small open (0.806cm³) and closed porosity (0.808cm³), which causes a higher bulk density (1.362g/cm³) if compared with sample 2, which has the open porosity (0.919cm³), closed porosity(1.127cm³) and bulk density (1.351g/cm³). The smaller particle forms an interconnecting structure that can trap the water molecules and increases the water absorption. The water absoption was 36.67% in sample 1 higher than that (33.24%) for sample 2. The 3D printing produces a ceramic membrane with an inhomogeneous structure which cause a deviation in its filtration rate. However, the membrane hole shape enhances the filtration rate by more than 50%, which is from 107.4ml/min to 171.1ml/min. The filtration rate was decreased with the treatment duration from 1 to 5 minutes due to the accumulation of particulate matters. The ceramic membrane with hole (1b and 2b) can improve the decreasing of filtration rate by 64.85% to 70.64% for particle size between 72μ to 133μ. The cleaning of the membrane was characterize by spectra detected by EDX and it shows an effectiveness in order to remove the accumulation of the particular matters after the backwash process. Among the samples, the ceramic membrane 1b has a higher efficiency in terms of chemical oxygen demand (COD) and total suspended solid (TSS), which were achieved 98.33% reduction in COD and 46.15% in TSS

A note on happiness and life satisfaction in Malaysia

Gross Domestic Product (GDP) has long been an indicator of economic growth.There is an on-going debate on whether high growth increases well-being.The terms ‘happiness’ and ‘life satisfaction’ are often used interchangeably to explain the subjective well-being levels of individuals.This study examines if both happiness and life satisfaction of Malaysian citizens are explained by the same factors based on a sample size of 1289 adopted from the 6th waves of World Values Survey (2010-2014).Outcomes from the ordered logit regression analysis indicate that income has strong positive relationship with happiness and life satisfaction.This study supports Easterlin paradox partially, which indicates a positive association between happiness and income in the short-term.Other common income related factors that have positive and strong significant impact on both happiness and life satisfaction are health status, employment and satisfaction on financial situation of household

Cause-related marketing: it's influence on consumers' choice of hypermarket

Malaysia has undergone market changes which lead to transformation from small shops to larger scale shops due to the globalization. The larger scale shop such as hypermarkets will increase the supply from local suppliers if the demand of consumers toward local product is high. This indicates that cause-related marketing concept can be applied if consumers are favour to hypermarkets that intend to support local product. Therefore, this study aims to examine the factors that influence consumers’ participation intention on “support local product” CRM campaign in the Malaysia context. There were six variables included to determine their effects on participation intention in “support local product” campaign which were firm motive, perceived corporate social responsibility, offer elaboration, brand attitude, ethnocentrism and environmental concern. Multiple regression and one-way ANOVA analysis were used to carry out data analysis. The results of multiple regression analysis indicated that all the predictors have significant relationships with participation intentions except for firm motive. Based on the findings, hypermarket might choose to engage in CRM campaign that use “support local product” as a cause. By doing so, it might assist the hypermarket to differentiate themselves with other competitors in retail industry

The CYP2C19*1/*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers

Background. The CYP2C19*2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether CYP2C19*2 alleles correlate with clopidogrel responsiveness following the administration of clopidogrel in healthy Malaysian volunteers. Methods. Ninety volunteers were genotyped for CYP2C19*2 and CYP2C19*3 alleles. Forty-five of 90 volunteers were included in the clopidogrel response studies and triaged into three genotypes, namely, CYP2C19*1/*1 (n=17), CYP2C19*1/*2 (n=21), and CYP2C19*2/*2 (n=7). All subjects received 300 mg of clopidogrel, and platelet reactivity was assessed after a four-hour loading utilizing the VerifyNow-P2Y12 assay. Platelet activity was reported using P2Y12 reaction units (PRUs), and nonresponder status was prespecified at PRU ≥ 230. Results. Following clopidogrel intake, CYP2C19*2/*2 carriers had a significantly higher mean PRU compared to the CYP2C19*1/*2 and CYP2C19*1/*1 (291.0 ± 62.1 versus 232.5 ± 81.4 versus 147.4 ± 87.2 PRU, P<0.001) carriers. Almost half of the participants (46.7%) were found to be nonresponders (3 were CYP2C19*1/*1, 11 were CYP2C19*1/*2, and 7 were CYP2C19*2/*2). Conclusion. In healthy Malaysian volunteers, CYP2C19*2 allele was associated with a decrease in platelet responsiveness to clopidogrel. However, clopidogrel nonresponders can be found not only in the carriers of CYP2C19*2/*2, but also in the carriers of CYP2C19*1/*2 and CYP2C19*1/*1. The present paper demonstrated that genotype information does not correlate with clopidogrel response, and genotyping may represent a less robust approach compared to platelet activity testing in guiding clopidogrel therapy

Development of high resolution melting analysis for the diagnosis of human malaria

Molecular detection has overcome limitations of microscopic examination by providing greater sensitivity and specificity in Plasmodium species detection. The objective of the present study was to develop a quantitative real-time polymerase chain reaction coupled with high-resolution melting (qRT-PCR-HRM) assay for rapid, accurate and simultaneous detection of all five human Plasmodium spp. A pair of primers targeted the 18S SSU rRNA gene of the Plasmodium spp. was designed for qRT-PCR-HRM assay development. Analytical sensitivity and specificity of the assay were evaluated. Samples collected from 229 malaria suspected patients recruited from Sabah, Malaysia were screened using the assay and results were compared with data obtained using PlasmoNexTM, a hexaplex PCR system. The qRT-PCR-HRM assay was able to detect and discriminate the five Plasmodium spp. with lowest detection limits of 1–100 copy numbers without nonspecific amplifications. The detection of Plasmodium spp. in clinical samples using this assay also achieved 100% concordance with that obtained using PlasmoNexTM. This indicated that the diagnostic sensitivity and specificity of this assay in Plasmodium spp. detection is comparable with those of PlasmoNexTM. The qRT-PCR-HRM assay is simple, produces results in two hours and enables high-throughput screening. Thus, it is an alternative method for rapid and accurate malaria diagnosis

Long-term evaluation of palm oil mill effluent (POME) steam reforming over lanthanum-based perovskite oxides

To replace the obsolete ponding system, palm oil mill effluent (POME) steam reforming (SR) over net-acidic LaNiO3 and net-basic LaCoO3 were proposed as the POME primary treatments, with promising H2-rich syngas production. Herein, the long-term evaluation of POME SR was scrutinized with both catalysts under the optimal conditions (600 °C, 0.09 mL POME/min, 0.3 g catalyst, & 74–105 μm catalyst particle size) to examine the catalyst microstructure changes, transient process stability, and final effluent evaluation. Extensive characterization proved the (i) adsorption of POME vapour on catalysts before SR, (ii) deposition of carbon and minerals on spent SR catalysts, and (iii) dominance of coking deactivation over sintering deactivation at 600 °C. Despite its longer run, spent LaCoO3 (50.54 wt%) had similar carbon deposition with spent LaNiO3 (50.44 wt%), concurring with its excellent coke resistance. Spent LaCoO3 (6.12 wt%; large protruding crystals) suffered a harsher mineral deposition than spent LaNiO3 (3.71 wt%; thin film coating), confirming that lower reactivity increased residence time of reactants. Transient syngas evolution of both SR catalysts was relatively steady up to 4 h but perturbed by coking deactivation thereafter. La2O2CO3 acted as an intermediate species that hastened the coke removal via reverse Boudouard reaction upon its decarbonation. La2O2CO3 decarbonation occurred continuously in LaCoO3 system but intermittently in LaNiO3 system. LaNiO3 system only lasted for 13 h as its compact ash blocked the gas flow. LaCoO3 system lasted longer (17 h) with its porous ash, but it eventually failed because KCl crystallites blocked its active sites. Relatively, LaCoO3 system offered greater net H2 production (72.78%) and POME treatment volume (30.77%) than LaNiO3 system. SR could attain appreciable POME degradation (>97% COD, BOD5, TSS, & colour intensity). Withal, SR-treated POME should be polished to further reduce its incompliant COD and BOD5

Genetic diversity of circumsporozoite protein in Plasmodium knowlesi isolates from Malaysian Borneo and Peninsular Malaysia

Understanding the genetic diversity of candidate genes for malaria vaccines such as circumsporozoite protein (csp) may enhance the development of vaccines for treating Plasmodium knowlesi. Hence, the aim of this study is to investigate the genetic diversity of non-repeat regions of csp in P. knowlesi from Malaysian Borneo and Peninsular Malaysia. A total of 46 csp genes were subjected to polymerase chain reaction amplification. The genes were obtained from P. knowlesi isolates collected from different divisions of Sabah, Malaysian Borneo, and Peninsular Malaysia. The targeted gene fragments were cloned into a commercial vector and sequenced, and a phylogenetic tree was constructed while incorporating 168 csp sequences retrieved from the GenBank database. The genetic diversity and natural evolution of the csp sequences were analysed using MEGA6 and DnaSP ver. 5.10.01. A genealogical network of the csp haplotypes was generated using NETWORK ver. 4.6.1.3. The phylogenetic analysis revealed indistinguishable clusters of P. knowlesi isolates across different geographic regions, including Malaysian Borneo and Peninsular Malaysia. Nucleotide analysis showed that the csp nonrepeat regions of zoonotic P. knowlesi isolates obtained in this study underwent purifying selection with population expansion, which was supported by extensive haplotype sharing observed between humans and macaques. Novel variations were observed in the C-terminal non-repeat region of csp. The csp non-repeat regions are relatively conserved and there is no distinct cluster of P. knowlesi isolates from Malaysian Borneo and Peninsular Malaysia. Distinctive variation data obtained in the C-terminal non-repeat region of csp could be beneficial for the design and development of vaccines to treat P. knowlesi

Вихретоковый анизотропный термоэлектрический первичный преобразователь лучистого потока

Представлена оригинальная конструкция первичного преобразователя лучистого потока, который может служить основой для создания приемника неселективного излучения с повышенной чувствительностью

Genome-Wide Association Study of Lung Adenocarcinoma in East Asia and Comparison With a European Population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications