SOME IMPLICATIONS OF THE TWO-CONSTRAINT JOINT RECREATIONAL CHOICE DEMAND MODEL

This paper explores the implications of applying a two-constraint joint recreational demand framework to estimate the demand for recreation at an Alaskan sportfishery. The demand for total days on-site and total trips per season are jointly estimated and used to parametrically define average on-site time and obtain consumer's surplus values.Resource /Energy Economics and Policy,

Valuing a Beach Day with a Repeated Nested Logit Model of Participation, Site Choice, and Stochastic Time Value

Beach recreation values are often needed by policy-makers and resource managers to efficiently manage coastal resources, especially in popular coastal areas like Southern California. This article presents welfare values derived from random utility maximization-based recreation demand models that explain an individual’s decisions about whether or not to visit a beach and which beach to visit. The models utilize labor market decisions to reveal each individual’s opportunity cost of recreation time. The value of having access to the beach in San Diego County is estimated to be between $21 and$23 per day.Recreation demand, repeated nested logit, labor supply, opportunity cost of leisure, time, beach recreation., Demand and Price Analysis, Environmental Economics and Policy, Institutional and Behavioral Economics, Q26, J22, Q51.,

Yeast Polarity: Negative Feedback Shifts the Focus

A new study of Cdc42p polarization in yeast suggests that the actin cytoskeleton can destabilize the polarity axis, causing Cdc42p foci to wander aimlessly around the cell cortex

ESTIMATING THE OPPORTUNITY COST OF RECREATION TIME IN AN INTEGRABLE 2-CONSTRAINT COUNT DEMAND MODEL

How researchers treat the opportunity cost of time substantially influences recreation demand parameter and welfare estimates. This paper presents a utility-theoretic and implementable approach, estimating the shadow value of time jointly with recreation demands for coastal activities, using a generalization of the semilog demand system in a two-constraint model.Consumer/Household Economics, Demand and Price Analysis,

The inhibition of neutrophil antibacterial activity by ultra-high molecular weight polyethylene particles.

Following infection, bacterial killing by polymorphonuclear leukocytes (neutrophils) is the main host defense against bacteria. Our hypothesis is that particles of ultra-high molecular weight polyethylene (UHMWP) may impair local neutrophil function and consequently reduce neutrophil bacterial killing. To determine how the in vitro phagocytic-bactericidal activity of neutrophils was affected by exposure to wear particles, tests were run comparing the effects of different particle composition, and different concentrations and sizes of UHMWP particles. There was a significant correlation between the number of particles and the decrease in neutrophil bactericidal activity (p<0.01), and the greatest effect was obtained with a concentration of 10(7) UHMWP/ml. There was a significant decrease in neutrophil bactericidal activity by incubation with particles of 0.1-5 microm (p<0.01), but not with larger size. The results suggest that neutrophil functional defects triggered by the presence of UHMWP particles may potentially contribute to the susceptibility of loose implants to bacterial infections

An algorithm for collapsing sign alternating sequences of real numbers

AbstractA table with two rows and n columns may be thought of as two vectors with n components. The distance between the two rows then corresponds to the norm of the difference between the rows. We examine the problem of how to collapse the adjacent columns of the table while keeping the norm of the difference as large as possible. First a stepwise algorithm is given which achieves this end with respect to the norm of the vector of differences. After proving the optimality of the stepwise solution we extend the result to the norm which arises from minimizing the number of persons misclassified. The same algorithm suffices

Polo-Like Kinase 2-Dependent Phosphorylation of NPM/B23 on Serine 4 Triggers Centriole Duplication

Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells. We previously reported that Polo-like kinase 2 (Plk2) is activated near the G1/S phase transition, and regulates the reproduction of centrosomes. In search for Plk2 interacting proteins we have identified NPM/B23 (Nucleophosmin) as a novel Plk2 binding partner. We find that Plk2 and NPM/B23 interact in vitro in a Polo-box dependent manner. An association between both proteins was also observed in vivo. Moreover, we show that Plk2 phosphorylates NPM/B23 on serine 4 in vivo in S-phase. Notably, expression of a non-phosphorylatable NPM/B23 S4A mutant interferes with centriole reduplication in S-phase arrested cells and leads to a dilution of centriole numbers in unperturbed U2OS cells. The corresponding phospho-mimicking mutants have the opposite effect and their expression leads to the accumulation of centrioles. These findings suggest that NPM/B23 is a direct target of Plk2 in the regulation of centriole duplication and that phosphorylation on serine 4 can trigger this process

Antimicrobial Peptide Exposure and Reduced Susceptibility to Daptomycin: Insights Into a Complex Genetic Puzzle

Adequate antibiotic treatment of bacteri-al infections is one of the most impor-tant problems of our time, not only because of the incessant development of antibiotic resistance, but also because of diminished development of novel anti-bacterial products. Attention has been focused on this problem by the recent United Nations World Health Day in April 2011, which highlighted antibiotic resistance and issued calls for urgent action by expert scientific panels tasked to establish priorities and solutions [1]. Among the proposals is a call for enhanced understanding of resistance, includin