Higher professional education is in penitentiary system: sociological analysis

Обобщаются результаты эксперимента по развитию высшего профессионального образования в пенитенциарной системе.The results of experiment are summarized on development of higher professional education in the penitentiary system

CRISPR

This review summarizes recent advances in endonuclease-mediated genome editing tools and research progress of genome-edited pigs as personalized test-systems for preclinical trials and as donors of organs with human-fit antigen profil

General Scheme of Risk – Oriented Audit Stages

The article examines the problem of applying risk-oriented approach in audit. A risk-oriented approach on the one hand allows to increase efficiency of auditors’ activity, the level of compliance with mandatory requirements, and on the other hand, to avoid the excessive inspections’ procedures in the formation of a scientifically grounded framework of reasonable sufficiency inherent to each specific audit. At the same time, risk-oriented approach needs to create its own methodological base, develop methodologies and relevant accompanying documents, and, most importantly, train personnel capable of implementing this innovative methodology. For this reason, topic of this paper is extremely relevant.     Keywords: audit, risk-oriented approach, planning, accounting (financial) statement

Substrate mineralization stimulates focal adhesion contact redistribution and cell motility of bone marrow stromal cells

Understanding the mechanisms of substrate based control of cell function is critical to the design of biomaterials. Cells interact with their extracellular matrix through cell adhesion contacts. We have previously described the self assembly of bone-like mineral onto an organic template and have shown that these biomimetic surfaces lead to an increased volume fraction of bone regenerated in vivo . In the present study, we compared the distribution of cell adhesion contacts, cell spreading, and cell motility of murine bone marrow stromal cells (BMSC) on mineralized vs. nonmineralized substrates. We developed a new approach for quantification of cell-material interactions and demonstrated that cell adhesion contacts on mineralized substrates were distributed throughout the cell surface contacting the substrate, whereas on nonmineralized substrates cell adhesion contacts were present near the cell periphery. We propose that mineralized substrates stimulate the predominant expression of fibrillar contacts, and nonmineralized substrates stimulate expression of focal adhesion contacts. Cell motility assays with colloidal gold demonstrated a statistically significant decrease in the average phagokinetic index of migrating cells on mineralized vs. nonmineralized substrates after 90 min of cell seeding. We propose that the physical–chemical properties of the substrate, altered by mineralization, cause expression of specific types of cell contacts and, as a result, modify molecular mechanisms responsible for cell spreading, motility, and possibly differentiation. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55848/1/30786_ftp.pd

Multicolour CCD photometric study of galactic star clusters SAI 63 and SAI 75

We present U B V I CCD photometric observations obtained in the field of open clusters SAI 63 and SAI 75. CCD optical data obtained for the first time for these clusters are used to derive the fundamental parameters of the clusters. Stellar surface density profile indicates that radii of SAI 63 and SAI 75 are ∼3′.5 and 2′.5 respectively. The reddenings E(B−V) are 0.44±0.05 and 0.34±0.05 mag for SAI 63 and SAI 75 respectively while the corresponding distances are 2.2 ± 0.2 and 3.5±0.3 kpc. An age of 450 ± 50 Myr for SAI 63 and 90 ± 10 Myr for SAI 75 is determined using the theoretical isochrones of Z=0.019. Our analysis shows that reddening law is normal towards SAI 75

The study of agronomical traits determining productivity of Triticum aestivum/Triticum timopheevii introgression lines with resistance to fungal diseases

Development of resistant cultivars is one of the effective ways for protection of common wheat T. aestivum L. from fungal pathogens. The gene pool of wild and cultivated wheat relatives is often used for widening the wheat genetic diversity of resistance genes. However, alien genetic material introgressed into the wheat genome can contain genetic factors negatively affecting agronomically important traits. T. aestivum/ T. timopheevii introgression lines derived from different common wheat cultivars have characteristically good resistance to leaf rust and powdery mildew. A comparative assessment of these lines and initial wheat varieties during four field seasons revealed a significant effect of environmental factors on the phenotypic differences between traits that have relevance to productivity. Averaged data obtained for individual introgression lines and for cross combinations revealed both positive and negative tendencies in variations of agronomical traits. The positive effects include a significant increase in the numbers of tillers and spikelets per spike of the lines derived from cv. Skala. Reduction in spike productivity was found in groups of the lines derived from cv. Tselinnaya 20 and cv. Novosibirskaya 67. However, no significant differences in 1000-grain weight were found between most lines and original wheat cultivars. Analysis of the data obtained showed no apparent correlation between the reduction of agronomic traits and the amount of alien genetic material introgressed into the common wheat genome. T. aestivum/T. timopheevii introgression lines can be used as a source of resistance genes without reducing the yield of wheat cultivars

Localization of the quantitative trait loci related to lodging resistance in spring bread wheat (<i>Triticum aestivum</i> L.)

The yield and grain quality of spring and winter wheat significantly depends on varieties’ resistance to lodging, the genetic basis of this trait being quantitative and controlled by a large number of loci. Therefore, the study of the genetic architecture of the trait becomes necessary for the creation and improvement of modern wheat varieties. Here we present the results of localization of the genomic regions associated with resistance to lodging, plant height, and upper internode diameter in Russian bread wheat varieties. Phenotypic screening of 97 spring varieties and breeding lines was carried out in the field conditions of the West Siberian region during 2017–2019. It was found that 54 % of the varieties could be characterized as medium and highly resistant to lodging. At the same time, it was noted that the trait varied over the years. Twelve varieties showed a low level of resistance in all years of evaluation. Plant height-based grouping of the varieties showed that 19 samples belonged to semi-dwarfs (60–84 cm), and the rest were included in the group of standard-height plants (85–100 cm). Quantitative trait loci (QTL) mapping was performed by means of genome-wide association study (GWAS) using 9285 SNP markers. For lodging resistance, plant height, and upper internode diameter, 26 significant associations (–log p &gt; 3) were found in chromosomes 1B, 2A, 3A, 3D, 4A, 5A, 5B, 5D, 6A, and 7B. The results obtained suggest that the regions of 700–711 and 597–618 Mb in chromosomes 3A and 6A, respectively, may contain clusters of genes that affect lodging resistance and plant height. No chromosome regions colocalized with the QTLs associated with lodging resistance or upper internode diameter were found. The present GWAS results may be important for the development of approaches for creating lodging-resistant varieties through marker-assisted and genomic selection

HARDWARE-SOFTWARE SYSTEMS IN PSYCHOLOGICAL SUPPORT FOR NUCLEAR POWER PLANT PERSONNEL

The problem of the human factor reliability in the nuclear industry is considered. The experience of development and application of modern hardware and software systems in the practice of psychological and psychophysiological support of nuclear plants’ personnel is analyzed. Promising directions for the development of psychological support for the reliability of personnel in the nuclear industry using hardware and software systems are presented. The classification of hardware and software systems (assisting, algorithmic, based on artificial intelligence) is given. The requirements for the qualification of users of the hardware and software systems of different categories are substantiated.Рассматривается проблема надежности человеческого фактора в атомной отрасли. Анализируется опыт разработки и применения специалистами Технической академии «Росатома» современных аппаратно-программных комплексов (АПК) в практике психологической и психофизиологической поддержки персонала в филиалах АО «Концерн Росэнергоатом». Представлены перспективные направления развития психологического обеспечения надежности персонала с использованием АПК. Приведена классификация АПК (помогающие, алгоритмические, на основе искусственного интеллекта), обоснованы требования к квалификации пользователей АПК разных классов