INSILICO DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL BENZOTHIAZOLE DERIVATIVES AS ANTI-CANCER AGENTS

Objectives: Cancer is a disease characterized by uncontrollable, irreversible, independent, autonomous, uncoordinated and relatively unlimited and abnormal over growth of tissues. Breast cancer is the second most common type of cancer after lung cancer. The aim of the study is to carry out the docking studies, synthesis and anti-tumour activities  of Benzothiazole derivatives containing oxadiazole groups or amino groups.Methods: The docking studies of benzothiazole derivatives were done with known anti-cancer targets like oestrogen receptor by using argus lab and auto dock programmes with the standard drug tamoxifen. Based upon  the results obtained from the molecular modeling, the derivatives were selected for the synthesis. The synthesized compounds were characterized by melting point, TLC, IR, 1H NMR, 13CNMR, MASS spectral data and screened for their in- vitro anti-cancer activities.Results: The docking scores obtained for benzothiazole derivatives (BT1,BT2,BT3,BT4) and std.tamoxifen  from the preliminary docking program by using  argusLab  were- 9.68,-9.4,-9.59, -11.1988,-9.71 and  by using autodock program were -6.29, -5.25,-7.19,-7.48,-3.86 respectively. All the four derivatives were synthesized, characterized and subjected to in vitro anticancer screening by MTT assay in breast cancer (MCF-7) cell lines. Compounds DBT1, DBT2, DBT3 were the most active compounds against MCF-7 cell lines with IC50 of 70.0, 64.0 and 65.0, respectively.Conclusion: All the four  derivatives show  good docking scores when compared to standard drug and can be concluded that all the synthesized benzothiazole  ligands show good anti-cancer property.Keywords: Benzothiazole, Oxadiazole, Estrogen receptor, Anticancer targets

BROAD PHONEME CLASSIFICATION USING SIGNAL BASED FEATURES

ABSTRACT Speech is the most efficient and popular means of human communicatio

Down-conversion processes in ab-initio non-relativistic quantum electrodynamics

The availability of efficient photon sources with specific properties is important for quantum-technological applications. However, the realization of such photon sources is often challenging and hence alternative perspectives that suggest new means to enhance desired properties while suppressing detrimental processes are valuable. In this work we highlight that ab-initio simulations of coupled light-matter systems can provide such new avenues. We show for a simple model of a quantum ring that by treating light and matter on equal footing we can create and enhance novel pathways for down-conversion processes. By changing the matter subsystem as well as the photonic environment in experimentally feasible ways, we can engineer hybrid light-matter states that enhance at the same time the efficiency of the down-conversion process and the non-classicality of the created photons. Furthermore we show that this also leads to a faster down-conversion, potentially avoiding detrimental decoherence effects.Comment: 26 pages, 29 figure

The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure

We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+−) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure

Role of Endothelial Progenitor Cells and Inflammatory Cytokines in Healing of Diabetic Foot Ulcers

Background: To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing. Methods: We studied healthy subjects, diabetic patients not at risk of DFU, at risk of DFU and with active DFU. We prospectively followed the DFU patients over a 12-week period. We also investigated similar changes in diabetic rabbit and mouse models of wound healing. Results: All EPC phenotypes except the kinase insert domain receptor (KDR)+CD133+ were reduced in the at risk and the DFU groups compared to the controls. There were no major EPC differences between the control and not at risk group, and between the at risk and DFU groups. Serum stromal-cell derived factor-1 (SDF-1) and stem cell factor (SCF) were increased in DFU patients. DFU patients who healed their ulcers had lower CD34+KDR+ count at visits 3 and 4, serum c-reactive protein (CRP) and granulocyte-macrophage colony-stimulating factor (GM-CSF) at visit 1, interleukin-1 (IL-1) at visits 1 and 4. EPCs tended to be higher in both diabetic animal models when compared to their non-diabetic counterparts both before and ten days after wounding. Conclusions: Uncomplicated diabetes does not affect EPCs. EPCs are reduced in patients at risk or with DFU while complete wound healing is associated with CD34+KDR+ reduction, suggesting possible increased homing. Low baseline CRP, IL-1α and GM-CSF serum levels were associated with complete wound healing and may potentially serve as prognostic markers of DFU healing. No animal model alone is representative of the human condition, indicating the need for multiple experimental models

Työelämää simuloivat kurssit ja työelämäyhteistyö yliopistojen käännösalan koulutuksissa

This article is based on papers presented at the seminar for the teachers’ and researchers’ section of the Finnish Association of Translators and Interpreters in August 2015. The theme of the seminar was courses currently offered within Finnish translator training that involve simulated or authentic aspects of professional business translation or are based on cooperation with the translation industry. After an overview of recent forms of cooperation at the five Finnish universities offering translator training, the article presents examples of courses with relevance for working as professional translators, interpreters, or other multilingual communications professionals. The examples include multilingual translation workshops involving project management, authentic or simulated translation assignments and a student-operated translation and interpreting co-operative. The article shows, firstly, that Finnish translator training offers a wide range of activities where the students not only have the opportunity to familiarize themselves with the demands and current practices of the industry but also to view them with a critical eye. Secondly, and perhaps even more importantly, the training institutions are motivated to develop translator and interpreter training further and to share experiences and good practices.This article is based on papers presented at the seminar for the teachers’ and researchers’ section of the Finnish Association of Translators and Interpreters in August 2015. The theme of the seminar was courses currently offered within Finnish translator training that involve simulated or authentic aspects of professional business translation or are based on cooperation with the translation industry. After an overview of recent forms of cooperation at the five Finnish universities offering translator training, the article presents examples of courses with relevance for working as professional translators, interpreters, or other multilingual communications professionals. The examples include multilingual translation workshops involving project management, authentic or simulated translation assignments and a student-operated translation and interpreting co-operative. The article shows, firstly, that Finnish translator training offers a wide range of activities where the students not only have the opportunity to familiarize themselves with the demands and current practices of the industry but also to view them with a critical eye. Secondly, and perhaps even more importantly, the training institutions are motivated to develop translator and interpreter training further and to share experiences and good practices