Fabrication of porous extended-release tablets using dual nozzle fused deposition modeling 3D printing techniques

The aim of this study was to fabricate shell-core porous tablet formulations by fused deposition modeling dual nozzle three-dimensional printing coupled with hot-melt extrusion techniques. Acetaminophen was selected as the model drug for this study owing to its pH-independent property. The 3-point bend test and the stiffness test were performed to investigate the printability of filaments. The stiffness constant, k, was calculated to represent the printability by fitting the breaking distances and stress data into Hooke’s law. The formulation 1 (F1) and formulation 2 (F2) filaments were printed successfully by demonstrating the preferred hardness with 16.74±3.55 and 14.72±2.20 respectively in k value (g/ mm3). In vitro dissolution studies were performed in phosphate buffer (pH 6.8) to evaluate the drug release rate of the printed tablets. Due to SEM images, drug load, and other factors, F1 core tablets demonstrated a faster dissolution profile than F2 core tablets. Three different porous shells were designed to extend dissolution profiles by sealing the core tablet in it. From the result, both formulations with shell-core porous tablets demonstrated an extended dissolution profile in all designs. Therefore, a novel extended-release porous shell-core tablet was successfully developed, by altering the hole’s quantity and location can acquire different dissolution profiles

A study of the causal relationship between IT governance inhibitors and its success in Korea enterprises

노트 : Proceedings of the 41st Hawaii International Conference on System Sciences - 2008 행사명 : 41st Hawaii International Conference on System Sc

High Bearing Temperature Troubleshooting of Centrifugal Heat-Pump Compressor

Case StudyOn September 2013, a centrifugal heat-pump compressor began showing an abnormal temperature rise in its tilting pad journal bearing (DE-side). The phenomenon appeared when increasing the rotor speed following a process of load-up. This case study presents the chronology of the investigation conducted to identify the root cause of the unacceptable temperature rise: Troubleshooting the cause of High Bearing Temperature. The troubleshooting process took several months while there were severe economic losses as the compressor could not deliver its full load

Simulated microgravity with floating environment promotes migration of non-small cell lung cancers

A migration of cancer is one of the most important factors affecting cancer therapy. Particularly, a cancer migration study in a microgravity environment has gained attention as a tool for developing cancer therapy. In this study, we evaluated the proliferation and migration of two types (adenocarcinoma A549, squamous cell carcinoma H1703) of non-small cell lung cancers (NSCLC) in a floating environment with microgravity. When we measured proliferation of two NSCLCs in the microgravity (MG) and ground-gravity (CONT), although initial cell adhesion in MG was low, a normalized proliferation rate of A549 in MG was higher than that in CONT. Wound healing results of A549 and H1703 showed rapid recovery in MG; particularly, the migration rate of A549 was faster than that of H1703 both the normal and low proliferating conditions. Gene expression results showed that the microgravity accelerated the migration of NSCLC. Both A549 and H1703 in MG highly expressed the migration-related genes MMP-2, MMP-9, TIMP-1, and TIMP-2 compared to CONT at 24 h. Furthermore, analysis of MMP-2 protein synthesis revealed weaker metastatic performance of H1703 than that of A549. Therefore, the simulated microgravity based cancer culture environment will be a potential for migration and metastasis studies of lung cancers

Downstream Impact Investigation of Released Sediment from Reservoir Desilting Operation

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Synthesis of Bifunctional Poly(Vinyl Phosphonic Acid-co-glycidyl Metacrylate-co-divinyl Benzene) Cation-Exchange Resin and Its Indium Adsorption Properties from Indium Tin Oxide Solution

ABSTRACT Poly(vinyl phosphonic acid-co-glycidyl methacrylate-co-divinyl benzene) (PVGD) and PVGD containing an iminodiacetic acid group (IPVGD), which has indium ion selectivity, were synthesized by suspension polymerization, and their indium adsorption properties were investigated. The synthesized PVGD and IPVGD resins were characterized using Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and mercury porosimetry. The cation-exchange capacity, the water uptake and the indium adsorption properties were investigated. The cation-exchange capacities of PVGD and IPVGD were 1.2 -4.5 meq/g and 2.5 -6.4 meq/g, respectively. The water uptakes were decreased with increasing contents of divinyl benzene (DVB). The water uptake values were 25% -40% and 20% -35%, respectively. The optimum adsorption of indium from a pure indium solution and an artificial indium tin oxide (ITO) solution by the PVGD and IPVGD ion-exchange resins were 2.3 and 3.5 meq/g, respectively. The indium adsorption capacities of IPVGD were higher than those of PVGD. The indium ion adsorption selectivity in the artificial ITO solution by PVGD and IPVGD was excellent, and other ions were adsorbed only slightly