The aim of this study was to fabricate shell-core porous tablet formulations by fused deposition modeling dual nozzle three-dimensional printing coupled with hot-melt extrusion techniques. Acetaminophen was selected as the model drug for this study owing to its pH-independent property. The 3-point bend test and the stiffness test were performed to investigate the printability of filaments. The stiffness constant, k, was calculated to represent the printability by fitting the breaking distances and stress data into Hooke’s law. The formulation 1 (F1) and formulation 2 (F2) filaments were printed successfully by demonstrating the preferred hardness with 16.74±3.55 and 14.72±2.20 respectively in k value (g/ mm3). In vitro dissolution studies were performed in phosphate buffer (pH 6.8) to evaluate the drug release rate of the printed tablets. Due to SEM images, drug load, and other factors, F1 core tablets demonstrated a faster dissolution profile than F2 core tablets. Three different porous shells were designed to extend dissolution profiles by sealing the core tablet in it. From the result, both formulations with shell-core porous tablets demonstrated an extended dissolution profile in all designs. Therefore, a novel extended-release porous shell-core tablet was successfully developed, by altering the hole’s quantity and location can acquire different dissolution profiles
