7,306 research outputs found
Entropies of Rotating Charged Black Holes from Conformal Field Theory at Killing Horizons
The covariant phase technique is used to compute the constraint algebra of
the stationary axisymmetric charged black hole. A standard Virasoro subalgebra
with corresponding central charge is constructed at a Killing horizon with
Carlip's boundary conditions. For the Kerr-Newman black hole and the
Kerr-Newman-AdS black hole, the density of states determined by conformal
fields theory methods yields the statistical entropy which agrees with the
Bekenstein-Hawking entropy.Comment: 12 pages, no figure, RevTe
The Quintessential CMB, Past & Future
The past, present and future of cosmic microwave background (CMB) anisotropy
research is discussed, with emphasis on the Boomerang and Maxima balloon
experiments. These data are combined with large scale structure (LSS)
information and high redshift supernova (SN1) observations to explore the
inflation-based cosmic structure formation paradigm. Here we primarily focus on
a simplified inflation parameter set, {omega_b,omega_{cdm},Omega_{tot},
Omega_Q,w_Q, n_s,tau_C, sigma_8}. After marginalizing over the other cosmic and
experimental variables, we find the current CMB+LSS+SN1 data gives
Omega_{tot}=1.04\pm 0.05, consistent with (non-baroque) inflation theory.
Restricting to Omega_{tot}=1, we find a nearly scale invariant spectrum, n_s
=1.03 \pm 0.07. The CDM density, omega_{cdm}=0.17\pm 0.02, is in the expected
range, but the baryon density, omega_b=0.030\pm 0.004, is slightly larger than
the current nucleosynthesis estimate. Substantial dark energy is inferred,
Omega_Q\approx 0.68\pm 0.05, and CMB+LSS Omega_Q values are compatible with the
independent SN1 estimates. The dark energy equation of state, parameterized by
a quintessence-field pressure-to-density ratio w_Q, is not well determined by
CMB+LSS (w_Q<-0.3 at 95%CL), but when combined with SN1 the resulting w_Q<-0.7
limit is quite consistent with the w_Q=-1 cosmological constant case. Though
forecasts of statistical errors on parameters for current and future
experiments are rosy, rooting out systematic errors will define the true
progress.Comment: 14 pages, 3 figs., in Proc. CAPP-2000 (AIP), CITA-2000-6
CMB Analysis of Boomerang & Maxima & the Cosmic Parameters {Omega_tot,Omega_b h^2,Omega_cdm h^2,Omega_Lambda,n_s}
We show how estimates of parameters characterizing inflation-based theories
of structure formation localized over the past year when large scale structure
(LSS) information from galaxy and cluster surveys was combined with the rapidly
developing cosmic microwave background (CMB) data, especially from the recent
Boomerang and Maxima balloon experiments. All current CMB data plus a
relatively weak prior probability on the Hubble constant, age and LSS points to
little mean curvature (Omega_{tot} = 1.08\pm 0.06) and nearly scale invariant
initial fluctuations (n_s =1.03\pm 0.08), both predictions of (non-baroque)
inflation theory. We emphasize the role that degeneracy among parameters in the
L_{pk} = 212\pm 7 position of the (first acoustic) peak plays in defining the
range upon marginalization over other variables. Though the CDM
density is in the expected range (\Omega_{cdm}h^2=0.17\pm 0.02), the baryon
density Omega_bh^2=0.030\pm 0.005 is somewhat above the independent 0.019\pm
0.002 nucleosynthesis estimate. CMB+LSS gives independent evidence for dark
energy (Omega_\Lambda=0.66\pm 0.06) at the same level as from supernova (SN1)
observations, with a phenomenological quintessence equation of state limited by
SN1+CMB+LSS to w_Q<-0.7 cf. the w_Q=-1 cosmological constant case.Comment: 11 pages, 3 figs., in Proc. IAU Symposium 201 (PASP), CITA-2000-6
Entropies of the general nonextreme stationary axisymmetric black hole: statistical mechanics and thermodynamics
Starting from metric of the general nonextreme stationary axisymmetric black
hole in four-dimensional spacetime, both statistical-mechanical and
thermodynamical entropies are studied. First, by means of the "brick wall"
model in which the Dirichlet condition is replaced by a scattering ansatz for
the field functions at the horizon and with Pauli-Villars regularization
scheme, an expression for the statistical-mechanical entropy arising from the
nonminimally coupled scalar fields is obtained. Then, by using the conical
singularity method Mann and Solodukhin's result for the Kerr-Newman black hole
(Phys. Rev. D54, 3932(1996)) is extended to the general stationary black hole
and the nonminimally coupled scalar field. We last shown by comparing the two
results that the statistical-mechanical entropy and one-loop correction to the
thermodynamical entropy are equivalent for coupling . After
renormalization, a relation between the two entropies is given.Comment: 18 pages, Latex, nofigue. Accepted by Phys. Rev.
Effect of angular momentum on equilibrium properties of a self-gravitating system
The microcanonical properties of a two dimensional system of N classical
particles interacting via a smoothed Newtonian potential as a function of the
total energy E and the total angular momentum L are discussed. In order to
estimate suitable observables a numerical method based on an importance
sampling algorithm is presented. The entropy surface shows a negative specific
heat region at fixed L for all L. Observables probing the average mass
distribution are used to understand the link between thermostatistical
properties and the spatial distribution of particles. In order to define a
phase in non-extensive system we introduce a more general observable than the
one proposed by Gross and Votyakov [Eur. Phys. J. B:15, 115 (2000)]: the sign
of the largest eigenvalue of the entropy surface curvature. At large E the
gravitational system is in a homogeneous gas phase. At low E there are several
collapse phases; at L=0 there is a single cluster phase and for L>0 there are
several phases with 2 clusters. All these pure phases are separated by first
order phase transition regions. The signal of critical behaviour emerges at
different points of the parameter space (E,L). We also discuss the ensemble
introduced in a recent pre-print by Klinko & Miller; this ensemble is the
canonical analogue of the one at constant energy and constant angular momentum.
We show that a huge loss of informations appears if we treat the system as a
function of intensive parameters: besides the known non-equivalence at first
order phase transitions, there exit in the microcanonical ensemble some values
of the temperature and the angular velocity for which the corresponding
canonical ensemble does not exist, i.e. the partition sum diverges.Comment: 17 pages, 11 figures, submitted to Phys. Rev.
Measurement of a Peak in the Cosmic Microwave Background Power Spectrum from the North American test flight of BOOMERANG
We describe a measurement of the angular power spectrum of anisotropies in
the Cosmic Microwave Background (CMB) from 0.3 degrees to ~10 degrees from the
North American test flight of the BOOMERANG experiment. BOOMERANG is a
balloon-borne telescope with a bolometric receiver designed to map CMB
anisotropies on a Long Duration Balloon flight. During a 6-hour test flight of
a prototype system in 1997, we mapped > 200 square degrees at high galactic
latitudes in two bands centered at 90 and 150 GHz with a resolution of 26 and
16.6 arcmin FWHM respectively. Analysis of the maps gives a power spectrum with
a peak at angular scales of ~1 degree with an amplitude ~70 uK.Comment: 5 pages, 1 figure LaTeX, emulateapj.st
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.
BackgroundT cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors performed in the 1990s.MethodsPatients with metastatic colorectal cancer (CRC) were treated in two phase 1 trials with first-generation retroviral transduced CAR-T cells targeting tumor-associated glycoprotein (TAG)-72 and including a CD3-zeta intracellular signaling domain (CART72 cells). In trial C-9701 and C-9702, CART72 cells were administered in escalating doses up to 1010 total cells; in trial C-9701 CART72 cells were administered by intravenous infusion. In trial C-9702, CART72 cells were administered via direct hepatic artery infusion in patients with colorectal liver metastases. In both trials, a brief course of interferon-alpha (IFN-α) was given with each CART72 infusion to upregulate expression of TAG-72.ResultsFourteen patients were enrolled in C-9701 and nine in C-9702. CART72 manufacturing success rate was 100% with an average transduction efficiency of 38%. Ten patients were treated in CC-9701 and 6 in CC-9702. Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (â€14 weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48 weeks. Trafficking to tumor tissues was confirmed in a tumor biopsy from one of three patients. A subset of patients had 111Indium-labeled CART72 cells injected, and trafficking could be detected to liver, but T cells appeared largely excluded from large metastatic deposits. Tumor biomarkers carcinoembryonic antigen (CEA) and TAG-72 were measured in serum; there was a precipitous decline of TAG-72, but not CEA, in some patients due to induction of an interfering antibody to the TAG-72 binding domain of humanized CC49, reflecting an anti-CAR immune response. No radiologic tumor responses were observed.ConclusionThese findings demonstrate the relative safety of CART72 cells. The limited persistence supports the incorporation of co-stimulatory domains in the CAR design and the use of fully human CAR constructs to mitigate immunogenicity
The Distances to Open Clusters from Main-Sequence Fitting. IV. Galactic Cepheids, the LMC, and the Local Distance Scale
We derive the basic properties of seven Galactic open clusters containing
Cepheids and construct their period-luminosity (P-L) relations. For our cluster
main-sequence fitting we extend previous Hyades-based empirical
color-temperature corrections to hotter stars using the Pleiades as a template.
We use BVI_{C}JHK_{s} data to test the reddening law, and include metallicity
effects to perform a more comprehensive study for our clusters than prior
efforts. The ratio of total to selective extinction R_V that we derive is
consistent with expectations. Assuming the LMC P-L slopes, we find =
-3.93 +/- 0.07 (statistical) +/- 0.14 (systematic) for 10-day period Cepheids,
which is generally fainter than those in previous studies. Our results are
consistent with recent HST and Hipparcos parallax studies when using the
Wesenheit magnitudes W(VI). Uncertainties in reddening and metallicity are the
major remaining sources of error in the V-band P-L relation, but a higher
precision could be obtained with deeper optical and near-infrared cluster
photometry. We derive distances to NGC4258, the LMC, and M33 of (m - M)_0 =
29.28 +/- 0.10, 18.34 +/- 0.06, and 24.55 +/- 0.28, respectively, with an
additional systematic error of 0.16 mag in the P-L relations. The distance to
NGC4258 is in good agreement with the geometric distance derived from water
masers [\Delta (m - M)_0 = 0.01 +/- 0.24]; our value for M33 is less consistent
with the distance from an eclipsing binary [\Delta (m - M)_0 = 0.37 +/- 0.34];
our LMC distance is moderately shorter than the adopted distance in the HST Key
Project, which formally implies an increase in the Hubble constant of 7% +/-
8%.Comment: 28 pages, 21 figures; accepted for publication in the Ap
Multiplicity Studies and Effective Energy in ALICE at the LHC
In this work we explore the possibility to perform ``effective energy''
studies in very high energy collisions at the CERN Large Hadron Collider (LHC).
In particular, we focus on the possibility to measure in collisions the
average charged multiplicity as a function of the effective energy with the
ALICE experiment, using its capability to measure the energy of the leading
baryons with the Zero Degree Calorimeters. Analyses of this kind have been done
at lower centre--of--mass energies and have shown that, once the appropriate
kinematic variables are chosen, particle production is characterized by
universal properties: no matter the nature of the interacting particles, the
final states have identical features. Assuming that this universality picture
can be extended to {\it ion--ion} collisions, as suggested by recent results
from RHIC experiments, a novel approach based on the scaling hypothesis for
limiting fragmentation has been used to derive the expected charged event
multiplicity in interactions at LHC. This leads to scenarios where the
multiplicity is significantly lower compared to most of the predictions from
the models currently used to describe high energy collisions. A mean
charged multiplicity of about 1000-2000 per rapidity unit (at ) is
expected for the most central collisions at .Comment: 12 pages, 19 figures. In memory of A. Smirnitski
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