Entropies of Rotating Charged Black Holes from Conformal Field Theory at Killing Horizons

The covariant phase technique is used to compute the constraint algebra of the stationary axisymmetric charged black hole. A standard Virasoro subalgebra with corresponding central charge is constructed at a Killing horizon with Carlip's boundary conditions. For the Kerr-Newman black hole and the Kerr-Newman-AdS black hole, the density of states determined by conformal fields theory methods yields the statistical entropy which agrees with the Bekenstein-Hawking entropy.Comment: 12 pages, no figure, RevTe

The Quintessential CMB, Past & Future

The past, present and future of cosmic microwave background (CMB) anisotropy research is discussed, with emphasis on the Boomerang and Maxima balloon experiments. These data are combined with large scale structure (LSS) information and high redshift supernova (SN1) observations to explore the inflation-based cosmic structure formation paradigm. Here we primarily focus on a simplified inflation parameter set, {omega_b,omega_{cdm},Omega_{tot}, Omega_Q,w_Q, n_s,tau_C, sigma_8}. After marginalizing over the other cosmic and experimental variables, we find the current CMB+LSS+SN1 data gives Omega_{tot}=1.04\pm 0.05, consistent with (non-baroque) inflation theory. Restricting to Omega_{tot}=1, we find a nearly scale invariant spectrum, n_s =1.03 \pm 0.07. The CDM density, omega_{cdm}=0.17\pm 0.02, is in the expected range, but the baryon density, omega_b=0.030\pm 0.004, is slightly larger than the current nucleosynthesis estimate. Substantial dark energy is inferred, Omega_Q\approx 0.68\pm 0.05, and CMB+LSS Omega_Q values are compatible with the independent SN1 estimates. The dark energy equation of state, parameterized by a quintessence-field pressure-to-density ratio w_Q, is not well determined by CMB+LSS (w_Q<-0.3 at 95%CL), but when combined with SN1 the resulting w_Q<-0.7 limit is quite consistent with the w_Q=-1 cosmological constant case. Though forecasts of statistical errors on parameters for current and future experiments are rosy, rooting out systematic errors will define the true progress.Comment: 14 pages, 3 figs., in Proc. CAPP-2000 (AIP), CITA-2000-6

CMB Analysis of Boomerang & Maxima & the Cosmic Parameters {Omega_tot,Omega_b h^2,Omega_cdm h^2,Omega_Lambda,n_s}

We show how estimates of parameters characterizing inflation-based theories of structure formation localized over the past year when large scale structure (LSS) information from galaxy and cluster surveys was combined with the rapidly developing cosmic microwave background (CMB) data, especially from the recent Boomerang and Maxima balloon experiments. All current CMB data plus a relatively weak prior probability on the Hubble constant, age and LSS points to little mean curvature (Omega_{tot} = 1.08\pm 0.06) and nearly scale invariant initial fluctuations (n_s =1.03\pm 0.08), both predictions of (non-baroque) inflation theory. We emphasize the role that degeneracy among parameters in the L_{pk} = 212\pm 7 position of the (first acoustic) peak plays in defining the $\Omega_{tot}$ range upon marginalization over other variables. Though the CDM density is in the expected range (\Omega_{cdm}h^2=0.17\pm 0.02), the baryon density Omega_bh^2=0.030\pm 0.005 is somewhat above the independent 0.019\pm 0.002 nucleosynthesis estimate. CMB+LSS gives independent evidence for dark energy (Omega_\Lambda=0.66\pm 0.06) at the same level as from supernova (SN1) observations, with a phenomenological quintessence equation of state limited by SN1+CMB+LSS to w_Q<-0.7 cf. the w_Q=-1 cosmological constant case.Comment: 11 pages, 3 figs., in Proc. IAU Symposium 201 (PASP), CITA-2000-6

Entropies of the general nonextreme stationary axisymmetric black hole: statistical mechanics and thermodynamics

Starting from metric of the general nonextreme stationary axisymmetric black hole in four-dimensional spacetime, both statistical-mechanical and thermodynamical entropies are studied. First, by means of the "brick wall" model in which the Dirichlet condition is replaced by a scattering ansatz for the field functions at the horizon and with Pauli-Villars regularization scheme, an expression for the statistical-mechanical entropy arising from the nonminimally coupled scalar fields is obtained. Then, by using the conical singularity method Mann and Solodukhin's result for the Kerr-Newman black hole (Phys. Rev. D54, 3932(1996)) is extended to the general stationary black hole and the nonminimally coupled scalar field. We last shown by comparing the two results that the statistical-mechanical entropy and one-loop correction to the thermodynamical entropy are equivalent for coupling $\xi\leq 0$. After renormalization, a relation between the two entropies is given.Comment: 18 pages, Latex, nofigue. Accepted by Phys. Rev.

Effect of angular momentum on equilibrium properties of a self-gravitating system

The microcanonical properties of a two dimensional system of N classical particles interacting via a smoothed Newtonian potential as a function of the total energy E and the total angular momentum L are discussed. In order to estimate suitable observables a numerical method based on an importance sampling algorithm is presented. The entropy surface shows a negative specific heat region at fixed L for all L. Observables probing the average mass distribution are used to understand the link between thermostatistical properties and the spatial distribution of particles. In order to define a phase in non-extensive system we introduce a more general observable than the one proposed by Gross and Votyakov [Eur. Phys. J. B:15, 115 (2000)]: the sign of the largest eigenvalue of the entropy surface curvature. At large E the gravitational system is in a homogeneous gas phase. At low E there are several collapse phases; at L=0 there is a single cluster phase and for L>0 there are several phases with 2 clusters. All these pure phases are separated by first order phase transition regions. The signal of critical behaviour emerges at different points of the parameter space (E,L). We also discuss the ensemble introduced in a recent pre-print by Klinko & Miller; this ensemble is the canonical analogue of the one at constant energy and constant angular momentum. We show that a huge loss of informations appears if we treat the system as a function of intensive parameters: besides the known non-equivalence at first order phase transitions, there exit in the microcanonical ensemble some values of the temperature and the angular velocity for which the corresponding canonical ensemble does not exist, i.e. the partition sum diverges.Comment: 17 pages, 11 figures, submitted to Phys. Rev.

Measurement of a Peak in the Cosmic Microwave Background Power Spectrum from the North American test flight of BOOMERANG

We describe a measurement of the angular power spectrum of anisotropies in the Cosmic Microwave Background (CMB) from 0.3 degrees to ~10 degrees from the North American test flight of the BOOMERANG experiment. BOOMERANG is a balloon-borne telescope with a bolometric receiver designed to map CMB anisotropies on a Long Duration Balloon flight. During a 6-hour test flight of a prototype system in 1997, we mapped > 200 square degrees at high galactic latitudes in two bands centered at 90 and 150 GHz with a resolution of 26 and 16.6 arcmin FWHM respectively. Analysis of the maps gives a power spectrum with a peak at angular scales of ~1 degree with an amplitude ~70 uK.Comment: 5 pages, 1 figure LaTeX, emulateapj.st

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.

BackgroundT cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors performed in the 1990s.MethodsPatients with metastatic colorectal cancer (CRC) were treated in two phase 1 trials with first-generation retroviral transduced CAR-T cells targeting tumor-associated glycoprotein (TAG)-72 and including a CD3-zeta intracellular signaling domain (CART72 cells). In trial C-9701 and C-9702, CART72 cells were administered in escalating doses up to 1010 total cells; in trial C-9701 CART72 cells were administered by intravenous infusion. In trial C-9702, CART72 cells were administered via direct hepatic artery infusion in patients with colorectal liver metastases. In both trials, a brief course of interferon-alpha (IFN-α) was given with each CART72 infusion to upregulate expression of TAG-72.ResultsFourteen patients were enrolled in C-9701 and nine in C-9702. CART72 manufacturing success rate was 100% with an average transduction efficiency of 38%. Ten patients were treated in CC-9701 and 6 in CC-9702. Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (≤14&nbsp;weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48&nbsp;weeks. Trafficking to tumor tissues was confirmed in a tumor biopsy from one of three patients. A subset of patients had 111Indium-labeled CART72 cells injected, and trafficking could be detected to liver, but T cells appeared largely excluded from large metastatic deposits. Tumor biomarkers carcinoembryonic antigen (CEA) and TAG-72 were measured in serum; there was a precipitous decline of TAG-72, but not CEA, in some patients due to induction of an interfering antibody to the TAG-72 binding domain of humanized CC49, reflecting an anti-CAR immune response. No radiologic tumor responses were observed.ConclusionThese findings demonstrate the relative safety of CART72 cells. The limited persistence supports the incorporation of co-stimulatory domains in the CAR design and the use of fully human CAR constructs to mitigate immunogenicity

The Distances to Open Clusters from Main-Sequence Fitting. IV. Galactic Cepheids, the LMC, and the Local Distance Scale

We derive the basic properties of seven Galactic open clusters containing Cepheids and construct their period-luminosity (P-L) relations. For our cluster main-sequence fitting we extend previous Hyades-based empirical color-temperature corrections to hotter stars using the Pleiades as a template. We use BVI_{C}JHK_{s} data to test the reddening law, and include metallicity effects to perform a more comprehensive study for our clusters than prior efforts. The ratio of total to selective extinction R_V that we derive is consistent with expectations. Assuming the LMC P-L slopes, we find = -3.93 +/- 0.07 (statistical) +/- 0.14 (systematic) for 10-day period Cepheids, which is generally fainter than those in previous studies. Our results are consistent with recent HST and Hipparcos parallax studies when using the Wesenheit magnitudes W(VI). Uncertainties in reddening and metallicity are the major remaining sources of error in the V-band P-L relation, but a higher precision could be obtained with deeper optical and near-infrared cluster photometry. We derive distances to NGC4258, the LMC, and M33 of (m - M)_0 = 29.28 +/- 0.10, 18.34 +/- 0.06, and 24.55 +/- 0.28, respectively, with an additional systematic error of 0.16 mag in the P-L relations. The distance to NGC4258 is in good agreement with the geometric distance derived from water masers [\Delta (m - M)_0 = 0.01 +/- 0.24]; our value for M33 is less consistent with the distance from an eclipsing binary [\Delta (m - M)_0 = 0.37 +/- 0.34]; our LMC distance is moderately shorter than the adopted distance in the HST Key Project, which formally implies an increase in the Hubble constant of 7% +/- 8%.Comment: 28 pages, 21 figures; accepted for publication in the Ap

Multiplicity Studies and Effective Energy in ALICE at the LHC

In this work we explore the possibility to perform ``effective energy'' studies in very high energy collisions at the CERN Large Hadron Collider (LHC). In particular, we focus on the possibility to measure in $pp$ collisions the average charged multiplicity as a function of the effective energy with the ALICE experiment, using its capability to measure the energy of the leading baryons with the Zero Degree Calorimeters. Analyses of this kind have been done at lower centre--of--mass energies and have shown that, once the appropriate kinematic variables are chosen, particle production is characterized by universal properties: no matter the nature of the interacting particles, the final states have identical features. Assuming that this universality picture can be extended to {\it ion--ion} collisions, as suggested by recent results from RHIC experiments, a novel approach based on the scaling hypothesis for limiting fragmentation has been used to derive the expected charged event multiplicity in $AA$ interactions at LHC. This leads to scenarios where the multiplicity is significantly lower compared to most of the predictions from the models currently used to describe high energy $AA$ collisions. A mean charged multiplicity of about 1000-2000 per rapidity unit (at $\eta \sim 0$) is expected for the most central $Pb-Pb$ collisions at $\sqrt{s_{NN}} = 5.5 TeV$.Comment: 12 pages, 19 figures. In memory of A. Smirnitski