Study of Multi-muon Events from EAS with the L3 Detector at Shallow Depth Underground

We present first preliminary data from the L3+Cosmics experiment and results from Monte Carlo simulations of multi-muon events as observed 30 m underground.Comment: 3 pages, 2 figures; presented at the 6th International Workshop on Topics in Astroparticle and Underground Physics, TAUP99, September 6-10, 1999, Paris, Franc

The typological debates around Le Jeu de la Hache (BnF MS Français 1996) and their stakes for HEMA practice

Le Jeu de la Hache displays a fighting-system with the pollaxe in armour, but the weapon is never described with precision, which leads to debates regarding its typology – cutting edge or hammer/raven’s beak? Through a semi-quantitative survey, we tried to offer an overview of current HEMA practice around this specific source, with special emphasis on the typological question. Despite the rather narrow scope of the inquiry, some trends emerge. Besides the various choices regarding terminology and sources, we can underline the variety of materials used for the simulators: rubber components («hammer» typology) are leading, but wood and metal are also used, for both typologies. Advantages and disadvantages of each rely on the articulation of safety and realism dimensions, and the dangerousness inherent to this kind of weapon is largely highlighted. Even if most respondents declare not to be familiar with the typological debates amongst historians, it was usually mentioned to them during their practice. Only a minority has taken part in experiments in order to bring some elements of answer, but seldom in a systematic way. Therefore, a praxeological experimental approach could bring up new data, but is not devoid of difficulties, for instance the necessity of wearing armour

Fighting with the Longsword: Modern-day HEMA Practices

This article is based on the talk presented on 27th November 2016 in the course of the Journées d’études sur le costume et les simulateurs d’armes dans les pratiques d’arts martiaux anciens. The talk itself involved practical demonstrations and interaction with other presentations given at the event; this article does not purport to be a transcript of the presentation, but elaborates on the key themes of the presentation: The objectives of HEMA as a modern practice, and their relationship to what we know about the historical practice of the European martial arts in the Middle Ages, including physical fitness, fencing techniques and tactical awareness, based on the Fechtbücher extant. A key element of the discussion involved a comparison between the objectives of and drivers behind historical and modern tournament rule-sets

DOSE REQUIREMENTS AND PLASMA CONCENTRATIONS OF PIPECURONIUM DURING BILATERAL RENAL EXCLUSION AND ORTHOTOPIC LIVER TRANSPLANTATION IN PIGS

We have studied five pigs undergoing bilateral clamping of the renal pedicles, seven pigs undergoing orthotopic liver transplantation and three control animals without surgery in order to examine the roles of the kidney and liver in the plasma clearance of pipecuronium. An i.v. infusion of pipecuronium was controlled to maintain a constant 90-95 % twitch depression throughout the investigation. The right sciatic nerve was stimulated continuously with supra-maximal stimuli at 0.1 Hz and the force of the corresponding evoked isometric muscle contraction was recorded continuously. Control pigs needed an infusion rate of pipecuronium 8-10.7 μg kg−1 min−1. In the renal group, it was necessary to reduce the infusion rate of pipecuronium by about 25% after clamping both renal vascular pedicles (P < 0.05 compared with controls); in pigs undergoing liver transplantation, it was necessary to reduce the rate by approximately 80% after clamping hepatic vessels (P < 0.05 compared with controls and from the period after clamping of renal vessels). After hepatic recirculation, the infusion rate of pipecuronium was increased progressively to a rate which corresponded to 50% of baseline values (P < 0.05 compared with the anhepatic phase and from controls). Plasma concentrations of pipecuronium were comparable in the three animal groups and did not change significantly during the study. These data suggest that the liver plays a more important role than the kidney in the plasma clearance of pipecuronium in pig

Caroli disease, bilateral diffuse cystic renal dysplasia, situs inversus, postaxial polydactyly, and preauricular fistulas: a ciliopathy caused by a homozygous NPHP3 mutation

We report the rare association of Caroli disease (intrahepatic bile duct ectasia associated with congenital hepatic fibrosis), bilateral cystic renal dysplasia, situs inversus, postaxial polydactyly, and preauricular fistulas in a female child. She presented with end-stage renal disease at the age of 1month, followed by a rapidly progressing hepatic fibrosis and dilatation of the intrahepatic bile ducts, leading to secondary biliary cirrhosis and portal hypertension. Combined liver-kidney transplantation was performed at the age of 4years, with excellent outcome. DNA analysis showed a NPHP3 (coding nephrocystin-3) homozygote mutation, confirming that this malformation complex is a ciliopathy. Conclusion: This rare association required an exceptional therapeutic approach: combined simultaneous orthotopic liver and kidney transplantation in a situs inversus recipient. The long-term follow-up was excellent with a very good evolution of the renal and hepatic grafts and normalization of growth and weight. This malformation complex has an autosomal recessive inheritance with a 25% recurrence risk in each pregnanc

Derivation of new diagnostic reference levels for neuro-paediatric computed tomography examinations in Switzerland.

Definition of new national diagnostic reference levels (DRLs) for volume computed tomography dose index (CTDI &lt;sub&gt;vol&lt;/sub&gt; ) and dose length product (DLP) for neuro-paediatric CT examinations depending on the medical indication. Paediatric cranial CT data sets acquired between January 2013 and December 2016 were retrospectively collected between July 2016 and March 2017 from eight of the largest university and cantonal hospitals that perform most of the neuro-paediatric CTs in Switzerland. A consensus review of CTDI &lt;sub&gt;vol&lt;/sub&gt; and DLP was undertaken for three defined anatomical regions: brain, facial bone, and petrous bone, each with and without contrast medium application. All indications for cranial CT imaging in paediatrics were assigned to one of these three regions. Descriptive statistical analysis of the distribution of the median values for CTDI &lt;sub&gt;vol&lt;/sub&gt; and DLP yielded values in the minimum, maximum, 25th percentile (1st quartile), median (2nd quartile), and 75th percentile (3rd quartile). New DRLs for neuro-paediatric CT examinations in Switzerland were based on the 75th percentiles of the distributions of the median values of all eight centres. Where appropriate, values were rounded such that the DRLs increase or at least remain constant as the age of the patient increases. Our results revealed DRLs for CTDI &lt;sub&gt;vol&lt;/sub&gt; and DLP up to 20% lower than the DRLs used so far in Switzerland and elsewhere in Europe. This study provides Swiss neuro-paediatric CT DRL values to establish optimum conditions for paediatric cranial CT examinations. Periodic national updates of DRLs, following international comparisons, are essential

EXPOSURE OF THE SWISS POPULATION BY RADIODIAGNOSTICS: 2013 REVIEW.

In 2013, a nationwide investigation was conducted in Switzerland to establish the population's exposure from medical X rays. A hybrid approach was used combining the Raddose database accessible on-line by the participating practices and the Swiss medical tariffication system for hospitals. This study revealed that the average annual number of examinations is 1.2 per inhabitant, and the associated annual effective dose is 1.4 mSv. It also showed that computed tomography is the most irradiating modality and that it delivers 70 % of the total dose. The annual effective dose per inhabitant registered a 17 % increase in 5 y and is comparable with what was recently reported in neighbouring countries

Chylothorax after surgery on congenital heart disease in newborns and infants -risk factors and efficacy of MCT-diet

<p>Abstract</p> <p>Objectives</p> <p>To analyze risk factors for chylothorax in infants after congenital heart surgery and the efficacy of median chain triglyceride diet (MCT). To develop our therapeutic pathway for the management of chylothorax.</p> <p>Patients and methods</p> <p>Retrospective review of the institutional surgical database and patient charts including detailed perioperative informations between 1/2000 and 10/2006. Data analyzing with an elimination regression analysis.</p> <p>Results</p> <p>Twenty six out of 282 patients had chylothorax (=9.2%). Secondary chest closure, low body weight, small size, longer cardiopulmonary bypass (242 ± 30 versus 129 ± 5 min) and x-clamp times (111 ± 15 versus 62 ± 3 min) were significantly associated with chylothorax (p < 0.05). One patient was cured with total parenteral nutrition (TPN) and one without any treatment. 24 patients received MCT-diet alone, which was successful in 17 patients within 10 days. After conversion to regular alimentation within one week only one chylothorax relapsed. Out of 7 patients primarily not responsive to MCT-diet, 2 were successfully treated by lysis of a caval vein thrombosis, 2 by TPN + pleurodesis + supradiaphragmatic thoracic duct ligation, one by octreotide treatment, and two patients finally died.</p> <p>Conclusions</p> <p>Chylothorax may appear due to injury of the thoracic duct, due to venous or lymphatic congestion, central vein thrombosis, or diffuse injury of mediastinal lymphatic tissue in association with secondary chest closure. Application of MCT alone was effective in 71%, and more invasive treatments like TPN should not be used in primary routine. After resolution of chylothorax, MCT-diet can be converted to regular milk formula within one week and with very low risk of relapse.</p