Theoretical Principles of In Vitro Selection Using Combinatorial Nucleic Acid Libraries

A new paradigm for drug discovery and biological research has developed from technologies that integrate combinatorial chemistry with rounds of selection and amplification, a technique called in vitro selection or systematic evolution of ligands by exponential enrichment (SELEX). This overview unit discusses nucleic acid libraries that can be used, affinity probability distributions, an equilibrium model for SELEX, and optimal conditions including concentrations and signalâ toâ noise ratios.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143632/1/cpnc0901.pd

Growing and Marketing Elderberries in Missouri (2012)

The American elderberry (Sambucus canadensis, also known as Sambucus nigra subsp. canadensis) is native to much of eastern and midwestern North America. The plant is a medium to large multiple-stemmed shrub, bush or small tree. Elderberry is commonly found growing in a range of habitats throughout Missouri, but it prefers moist, well-drained, sunny sites and is often found along roadside ditches and streams.By Patrick L. Byers, Andrew L. Thomas, Mihaela M. Cernusca, Larry D. Godsey and Michael A. Gold (University of Missouri)Includes bibliographical reference

Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer

Lung cancer is the leading cause of cancer deaths, because ~84% of cases are diagnosed at an advanced stage. Worldwide in 2008, ~1.5 million people were diagnosed and ~1.3 million died – a survival rate unchanged since 1960. However, patients diagnosed at an early stage and have surgery experience an 86% overall 5-year survival. New diagnostics are therefore needed to identify lung cancer at this stage. Here we present the first large scale clinical use of aptamers to discover blood protein biomarkers in disease with our breakthrough proteomic technology. This multi-center case-control study was conducted in archived samples from 1,326 subjects from four independent studies of non-small cell lung cancer (NSCLC) in long-term tobacco-exposed populations. We measured >800 proteins in 15uL of serum, identified 44 candidate biomarkers, and developed a 12-protein panel that distinguished NSCLC from controls with 91% sensitivity and 84% specificity in a training set and 89% sensitivity and 83% specificity in a blinded, independent verification set. Performance was similar for early and late stage NSCLC. This is a significant advance in proteomics in an area of high clinical need

The Ursinus Weekly, March 18, 1971

Flott on Indo-China, Richette on justice featured in Forums • Students criticize curriculum; art expansion most favored • Know your rights • State of our prisons: Ursinus students succeed at breaking in • Editorial: Ready or not, here we come • Letters to the editor: Parting shot; One year later; Plaid panned; Off the grass; Pathetic reformers • Movie critic: Academy awards • Faculty portrait: Dr. John J. Heilemann • Trackmen grab MAC title • UC grapplers finish 8-2, best season in 15 yearshttps://digitalcommons.ursinus.edu/weekly/1141/thumbnail.jp

The Ursinus Weekly, April 1, 1971

Pilot group sets guidelines for Ursinus Student Union • UC morality survey tabulated; Sophomore promiscuity revealed • Chapter scholars named • April social life • State of our prisons: Prisoners relate restrictive conditions at Graterford • Editorial: Unsightly minority • Focus: Warren Cohen • Shrunken heads • From the editor\u27s desk: Twenty-five months later • Movie critic: Lovers and other strangers; Cold turkey • Lana addresses Psychology Club • USGA consolidated notes • Team prepares for Swarthmore; Gurzynski hopeful for M.A.C. • Sports corner • Snellbelles vie in Delaware hoop tourney • Baseball previewhttps://digitalcommons.ursinus.edu/weekly/1143/thumbnail.jp