Sistem Informasi Perpustakaan Menggunakan Radio Frequency Identification Berbasis Client Server Pada SMP Negeri 3 Juwana

SMP Negeri 3 Juwana merupakan salah satu instansi pendidikan milik pemerintah kabupaten Pati yang terletak di kecamatan Juwana pada jalan Hangtuah desa Kudukeras. Sekolahan tersebut masih mengalami kesulitan dalam pengolahan data sekolah, khususnya pengolahan data pada perpustakaan yang masih menggunakan cara manual yaitu dengan cara menuliskan pada buku besar dalam proses peminjaman dan pengembalian buku serta pembuatan laporan – laporan data perpustakaan. Oleh karena itu dibutuhkan sistem perpustakaan yang terkomputerisasi dan berbasiskan Client server, untuk proses peminjaman dan pengembalian buku secara otomatis yang menghasilkan informasi yang cepat dan tepat. Dalam pengembangan sistem informasi di SMP Negeri 3 Juwana digunakan adalah menggunakan model pengembangan R & D, aplikasi ini dibuat menggunakan MySQL untuk database, alat reader RFID (Radio Frequency Identification)sebagai alat untuk scan kartu, serta aplikasi Borland Delphi sebagai alat untuk pembuatan sistem informasi perpustakaan tersebut. Hasil penelitian ini berupa aplikasi Sstem Informasi Perpustakaan Menggunakan Radio Frequency Identification Berbasis Client Server untuk membantu mempercepat proses pencatatan data perpustakaan, peminjaman dan pengembalian buku, serta pembuatan laporan – laporan data perpustakaan, selain itu aplikasi dibuat untuk mengurangi kesalahan user pada saat melakukan semua proses pendataan dan transaksi di perpustakaan SMP Negeri 3 Juwana

Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

AbstractThe establishment of relative size of organs and structures is paramount for attaining final form and function of an organism. Importantly, variation in the proportions of structures frequently underlies adaptive change in morphology in evolution and maybe a common mechanism underlying selection. However, the mechanism by which growth is integrated within tissues during development to achieve proper proportionality is poorly understood. We have shown that signaling by potassium channels mediates coordinated size regulation in zebrafish fins. Recently, calcineurin inhibitors were shown to elicit changes in zebrafish fin allometry as well. Here, we identify the potassium channelkcnk5bas a key player in integrating calcineurin’s growth effects, in part through regulation of the cytoplasmic C-terminus of the channel. We propose that the interaction between Kcnk5b and calcineurin acts as a signaling node to regulate allometric growth. Importantly, we find that this regulation is epistatic to inherent mechanisms instructing overall size as inhibition of calcineurin is able to bypass genetic instruction of size as seen insofand wild-type fins, however, it is not sufficient to re-specify positional memory of size of the fin. These findings integrate classic signaling mediators such as calcineurin with ion channel function in the regulation of size and proportion during growth.</jats:p

Preventable infectious diseases using vaccination in developmental age in the Province of Frosinone, Italy

Introduction. A study has been made of the behaviour of preventable infectious diseases by means of vaccination in the developmental age, reported between 1995 and 2003, in the area of Frosinone and Province, Italy. Results. Analysis of the distribution of the 185 cases of hepatitis B notified, demonstrates that the mean age has increased from 26.5 to 41.1 years. Notifications of invasive diseases due to haemophilus influenzae type b (Hib) refer exclusively to 13 cases of meningitis. As far as concerns pertussis, 119 cases have been reported (median age 4.0 years, mode 1.0). Overall 850 cases of measles were reported (median age 7.0 years, mode 5.0), the highest number being recorded in 1997 (349 cases: median age 7.0 years, mode 5.0) and 2002 (199 cases: median age 8.0 years, mode 8.0). Rubella occurred in 411 cases (median age 12.0 years, mode 11.0), with 53.3% involving females. As far as concerns mumps, the last peak of the epidemic occurred in 2001 (median age 7.0 years, mode 6.0) with 137 cases. Discussion and conclusion. Results emerging from the study demonstrate a reduction in time in the number of notifications for almost all the diseases under consideration. The distribution of the cases of rubella in fertile females, in 2002, stresses the need to promote campaigns in order to recuperate still-susceptible women of childbearing age. The cases of hepatitis B, pertussis and meningitis due to Hib confirm the high rate of protection resulting from vaccination. The incidence rates of measles, mumps, rubella and pertussis when compared with those of the paediatric sentinel surveillance system (SPES) clearly demonstrate not only that these are underestimated but also reveal controversial findings with respect to data provided by Infectious Diseases Italian Surveillance System (SIMI)

Optically Based Charge Injection System for Ionization Detectors

An optically coupled charge injection system for ionization based radiation detectors which allows a test charge to be injected without the creation of ground loops has been developed. An ionization like signal from an external source is brought into the detector through an optical fiber and injected into the electrodes by means of a photodiode. As an application example, crosstalk measurements on a liquid Argon electromagnetic calorimeter readout electrodes were performed

3,5-Diiodo-L-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver.

Recent reports demonstrated that 3,5-diiodo-l-thyronine (T(2)) was able to prevent lipid accumulation in the liver of rats fed a high-fat diet (HFD). In this study, we investigated how the rat liver responds to HFD and T(2) treatment by assessing the transcription profiles of some genes involved in the pathways of lipid metabolism: oxidation, storage and secretion. The mRNA levels of the peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARδ), and of their target enzymes acyl-CoA oxidase and stearoyl-CoA desaturase were evaluated by real-time RT-PCR. Moreover, the expression of the adipose triglyceride lipase involved in lipid mobilisation, of the main PAT proteins acting in lipid droplet (LD) turnover, and of apoprotein B (apo B), the major protein component of very low-density lipoproteins (VLDLs) were analysed. Overall, our data demonstrated that T(2) administration to HFD rats counteracts most of the hepatic transcriptional changes that occurred in response to the excess exogenous fat. In particular, our results suggest that T(2) may prevent the pathways leading to lipid storage in LDs, promote the processes of lipid mobilisation from LDs and secretion as VLDL, in addition to the stimulation of pathways of lipid oxidation. In conclusion, our findings might give an insight into the mechanisms underlying the anti-steatotic ability of T(2) and help to define the potential therapeutic role of T(2) for preventing or treating liver steatosis

Facile and E-Selective Intramolecular Ring-Closing Metathesis Reactions in 3_(10)-Helical Peptides: A 3D Structural Study

The ring-closing metathesis reaction can be used to cross-link allylated serine residues situated at the i and i + 3 positions in 3_(10)-helical peptides containing the helicogenic amino acid, α-aminoisobutyric acid (Aib). An octapeptide with the sequence Boc-Aib-Aib-Aib-Ser(Al)-Aib-Aib-Ser(Al)-Aib-OMe was found to undergo a facile and >20:1 E-selective ring-closing metathesis (RCM) reaction catalyzed by the Grubbs second-generation catalyst to yield an 18-membered macrocycle. The formation of this cross-link does not significantly disturb the peptide's native 3_(10)-helicity, as judged by an X-ray diffraction study of the acyclic diene, the E-olefin RCM product, and its hydrogenated derivative. A heptapeptide system with the sequence Boc-Val-Ser(Al)-Leu-Aib-Ser(Al)-Val-Leu-OMe also underwent an efficient RCM reaction, albeit with diminished E-selectivity. It is apparent from these studies that a minimal, RCM-derived, macrocyclic constraint can be readily incorporated into 3_(10)-helical peptides

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression

The role of p53 in neurodegenerative diseases is essentially associated with neuronal death. Recently an alternative point of view is emerging, as altered p53 conformation and impaired protein function have been found in fibroblasts and blood cells derived from Alzheimer's disease patients. Here, using stable transfected SH-SY5Y cells overexpressing APP751wt (SY5Y-APP) we demonstrated that the expression of an unfolded p53 conformation compromised neuronal functionality. In particular, these cells showed (i) augmented expression of amyloid precursor protein (APP) and its metabolites, including the C-terminal fragments C99 and C83 and β-amyloid peptide (ii) high levels of oxidative markers, such as 4-hydroxy-2-nonenal Michael-adducts and 3-nitro-tyrosine and (iii) altered p53 conformation, mainly due to nitration of its tyrosine residues. The consequences of high-unfolded p53 expression resulted in loss of p53 pro-apoptotic activity, and reduction of growth-associated protein 43 (GAP-43) mRNA and protein levels. The role of unfolded p53 in cell death resistance and lack of GAP-43 transcription was demonstrated by ZnCl(2) treatment. Zinc supplementation reverted p53 wild-type tertiary structure, increased cells sensitivity to acute cytotoxic injury and GAP-43 levels in SY5Y-APP clone

Preliminary definitions for the sonographic features of synovitis in children

Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research

Tests of an environmental and personnel safe cleaning process for BNL accelerator and storage ring components

A large measure of the successful operation of the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory (BNL) for over a decade can be attributed to the cleaning of its UHV components during and after construction. A new UHV cleaning process, which had to be environmentally and personnel safe, was needed to replace the harsh, unfriendly process which was still in use. Dow Advanced Cleaning Systems was contracted to develop a replacement process without the use of harsh chemicals and which must clean vacuum surfaces as well as the existing process. Acceptance of the replacement process was primarily based on Photon Stimulated Desorption (PSD) measurements of beam tube samples run on NSLS beam line U10B. One meter long beam tube samples were fabricated from aluminum, 304 stainless steel and oxygen free copper. Initially, coupon samples were cleaned and passed preliminary testing for the proposed process. Next, beam tube samples of each material were cleaned, and the PSD measured on beam line U10B using white light with a critical energy of 487 ev. Prior to cleaning, the samples were contaminated with a mixture of cutting oils, lubricants, vacuum oils and vacuum grease. The contaminated samples were then baked. Samples of each material were also cleaned with the existing process after the same preparation. Beam tube samples were exposed to between 10{sup 22} and 10{sup 23} photons per meter for a PSD measurement. Desorption yields for H{sub 2}, CO, CO{sub 2}, CH{sub 4} and H{sub 2}O are reported for both the existing cleaning and for the replacement cleaning process. Preliminary data, residual gas scans, and PSD results are given and discussed. The new process is also compared with new cleaning methods developed in other laboratories