Design and Construction of a Soil Bentonite Slurry Wall Around an Operating Facility Superfund Site

A soil bentonite slurry wall was designed for an NPL site to stop further migration of chemicals in a complex aquifer system, and to facilitate the removal of possible chemical sources from saturated zones beneath the site. Pumping from within the slurry wall will maintain inward and upward hydraulic gradients and thus stop further lateral or vertical migration of chemicals from the contained area. The slurry wall was constructed under an exceptionally detailed Quality Assurance; Quality Control review by the Contractor and two independent consulting firms. Ground movements, vibration levels and opacity of dust produced during construction were monitored for compliance with design specifications. It was made a condition of the contract that no hazardous material could leave the site. Federal regulations required all persons involved in site work to have health and safety training. Careful planning and close liaison between the Owner, Engineer and Contractor has enabled the slurry wall to be constructed in a business park environment around an operating manufacturing facility without disruption to production

The X-ray luminosity function of AGN at z~3

We combine Lyman-break colour selection with ultradeep (> 200 ks) Chandra X-ray imaging over a survey area of ~0.35 deg^2 to select high redshift AGN. Applying careful corrections for both the optical and X-ray selection functions, the data allow us to make the most accurate determination to date of the faint end of the X-ray luminosity function (XLF) at z~3. Our methodology recovers a number density of X-ray sources at this redshift which is at least as high as previous surveys, demonstrating that it is an effective way of selecting high z AGN. Comparing to results at z=1, we find no evidence that the faint slope of the XLF flattens at high z, but we do find significant (factor ~3.6) negative evolution of the space density of low luminosity AGN. Combining with bright end data from very wide surveys we also see marginal evidence for continued positive evolution of the characteristic break luminosity L*. Our data therefore support models of luminosity-dependent density evolution between z=1 and z=3. A sharp upturn in the the XLF is seen at the very lowest luminosities (Lx < 10^42.5 erg s^-1), most likely due to the contribution of pure X-ray starburst galaxies at very faint fluxes.Comment: 16 pages, 9 figures, accepted for publication in MNRA

A Modified Field Infiltrometer Test for Clay Liners

Regulatory agencies are looking more frequently to in situ field hydraulic conductivity tests for the assessment of a liner\u27s compliance to a specified hydraulic conductivity. Most field tests have evaluated hydraulic conductivity by measuring the infiltration rate of the liner. The infiltration rate can be used to arrive at a hydraulic conductivity value if the hydraulic boundary conditions of the test can be identified or if the head loss at different depths can be measured. A test fill of a clay liner was evaluated for its saturated vertical hydraulic conductivity. This paper discusses the use of eight tensiometers to measure soil suction at four depths beneath a double ring infiltrometer. The hydraulic conductivity results using the tensiometer data displayed good consistency and agreed well with laboratory test results

Focusing in Asynchronous Games

Game semantics provides an interactive point of view on proofs, which enables one to describe precisely their dynamical behavior during cut elimination, by considering formulas as games on which proofs induce strategies. We are specifically interested here in relating two such semantics of linear logic, of very different flavor, which both take in account concurrent features of the proofs: asynchronous games and concurrent games. Interestingly, we show that associating a concurrent strategy to an asynchronous strategy can be seen as a semantical counterpart of the focusing property of linear logic

Perspective: Vitamin D deficiency and COVID‐19 severity – plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis

Background SARS‐CoV‐2 coronavirus infection ranges from asymptomatic through to fatal COVID‐19 characterized by a ‘cytokine storm’ and lung failure. Vitamin D deficiency has been postulated as a determinant of severity. Objectives To review the evidence relevant to vitamin D and COVID‐19. Methods Narrative review. Results Regression modelling shows that more northerly countries in the Northern Hemisphere are currently (May 2020) showing relatively high COVID‐19 mortality, with an estimated 4.4% increase in mortality for each 1 degree latitude north of 28 degrees North (P = 0.031) after adjustment for age of population. This supports a role for ultraviolet B acting via vitamin D synthesis. Factors associated with worse COVID‐19 prognosis include old age, ethnicity, male sex, obesity, diabetes and hypertension and these also associate with deficiency of vitamin D or its response. Vitamin D deficiency is also linked to severity of childhood respiratory illness. Experimentally, vitamin D increases the ratio of angiotensin‐converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury. Conclusions Substantial evidence supports a link between vitamin D deficiency and COVID‐19 severity but it is all indirect. Community‐based placebo‐controlled trials of vitamin D supplementation may be difficult. Further evidence could come from study of COVID‐19 outcomes in large cohorts with information on prescribing data for vitamin D supplementation or assay of serum unbound 25(OH) vitamin D levels. Meanwhile, vitamin D supplementation should be strongly advised for people likely to be deficient

AEGIS: Infrared Spectroscopy of An Infrared Luminous Lyman Break Galaxy at z=3.01

We report the detection of rest--frame 6.2 and 7.7 \micron emission features arising from Polycyclic Aromatic Hydrocarbons (PAH) in the Spitzer/IRS spectrum of an infrared-luminous Lyman break galaxy at z=3.01. This is currently the highest redshift galaxy where these PAH emission features have been detected. The total infrared luminosity inferred from the MIPS 24 \micron and radio flux density is 2$\times10^{13}$ L$_{\odot}$, which qualifies this object as a so--called hyperluminous infrared galaxy (HyLIRG). However, unlike local HyLIRGs which are generally associated with QSO/AGNs and have weak or absent PAH emission features, this HyLIRG has very strong 6.2 and 7.7 \micron PAH emission. We argue that intense star formation dominates the infrared emission of this source, although we cannot rule out the presence of a deeply obscured AGN. This LBG appears to be a distorted system in the HST ACS F606W and F814W images, possibly indicating that a significant merger or interaction is driving the large IR luminosity

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight

Alterations in cytosine-5 DNA methylation are frequently observed in most types of human cancer. Although assays utilizing PCR amplification of bisulfite-converted DNA are widely employed to analyze these DNA methylation alterations, they are generally limited in throughput capacity, detection sensitivity, and or resolution. Digital PCR, in which a DNA sample is analyzed in distributive fashion over multiple reaction chambers, allows for enumeration of discrete template DNA molecules, as well as sequestration of non-specific primer annealing templates into negative chambers, thereby increasing the signal-to-noise ratio in positive chambers. Here, we have applied digital PCR technology to bisulfite-converted DNA for single-molecule high-resolution DNA methylation analysis and for increased sensitivity DNA methylation detection. We developed digital bisulfite genomic DNA sequencing to efficiently determine single-basepair DNA methylation patterns on single-molecule DNA templates without an interim cloning step. We also developed digital MethyLight, which surpasses traditional MethyLight in detection sensitivity and quantitative accuracy for low quantities of DNA. Using digital MethyLight, we identified single-molecule, cancer-specific DNA hypermethylation events in the CpG islands of RUNX3, CLDN5 and FOXE1 present in plasma samples from breast cancer patients

Driver behaviour with adaptive cruise control

This paper reports on the evaluation of adaptive cruise control (ACC) from a psychological perspective. It was anticipated that ACC would have an effect upon the psychology of driving, i.e. make the driver feel like they have less control, reduce the level of trust in the vehicle, make drivers less situationally aware, but workload might be reduced and driving might be less stressful. Drivers were asked to drive in a driving simulator under manual and ACC conditions. Analysis of variance techniques were used to determine the effects of workload (i.e. amount of traffic) and feedback (i.e. degree of information from the ACC system) on the psychological variables measured (i.e. locus of control, trust, workload, stress, mental models and situation awareness). The results showed that: locus of control and trust were unaffected by ACC, whereas situation awareness, workload and stress were reduced by ACC. Ways of improving situation awareness could include cues to help the driver predict vehicle trajectory and identify conflicts

AEGIS: Chandra Observation of DEEP2 Galaxy Groups and Clusters

We present a 200 ksec Chandra observation of seven spectroscopically selected, high redshift (0.75 < z < 1.03) galaxy groups and clusters discovered by the DEEP2 Galaxy Redshift Survey in the Extended Groth Strip (EGS). X-ray emission at the locations of these systems is consistent with background. The 3-sigma upper limits on the bolometric X-ray luminosities (L_X) of these systems put a strong constraint on the relation between L_X and the velocity dispersion of member galaxies sigma_gal at z~1; the DEEP2 systems have lower luminosity than would be predicted by the local relation. Our result is consistent with recent findings that at high redshift, optically selected clusters tend to be X-ray underluminous. A comparison with mock catalogs indicates that it is unlikely that this effect is entirely caused by a measurement bias between sigma_gal and the dark matter velocity dispersion. Physically, the DEEP2 systems may still be in the process of forming and hence not fully virialized, or they may be deficient in hot gas compared to local systems. We find only one possibly extended source in this Chandra field, which happens to lie outside the DEEP2 coverage.Comment: 5 pages, 3 figures. Accepted for publication in AEGIS ApJ Letters special editio