1,699 research outputs found

    Pushing Therapeutic Boundaries: iPSC Therapy for Duchenne\u27s Muscular Dystrophy

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    Evolution, Free Will, and Determinism: Nature Controls Our Morality

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    HybridMingler: Towards Mixed-Reality Support for Mingling at Hybrid Conferences

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    Mingling, the activity of ad-hoc, private, opportunistic conversations ahead of, during, or after breaks, is an important socializing activity for attendees at scheduled events, such as in-person conferences. The Covid-19 pandemic had a dramatic impact on the way conferences are organized, so that most of them now take place in a hybrid mode where people can either attend on-site or remotely. While on-site attendees can resume in-person mingling, hybrid modes make it challenging for remote attendees to mingle with on-site peers. In addressing this problem, we propose a collaborative mixed-reality (MR) concept, including a prototype, called HybridMingler. This is a distributed MR system supporting ambient awareness and allowing both on-site and remote conference attendees to virtually mingle. HybridMingler aims to provide both on-site and remote attendees with a spatial sense of co-location in the very same venue location, thus ultimately improving perceived presence

    Outage performance analysis and SWIPT optimization in energy-harvesting wireless sensor network deploying NOMA

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    Thanks to the benefits of non-orthogonal multiple access (NOMA) in wireless communications, we evaluate a wireless sensor network deploying NOMA (WSN-NOMA), where the destination can receive two data symbols in a whole transmission process with two time slots. In this work, two relaying protocols, so-called time-switching-based relaying WSN-NOMA (TSR WSN-NOMA) and power-splitting-based relaying WSN-NOMA (PSR WSN-NOMA) are deployed to study energy-harvesting (EH). Regarding the system performance analysis, we obtain the closed-form expressions for the exact and approximate outage probability (OP) in both protocols, and the delay-limited throughput is also evaluated. We then compare the two protocols theoretically, and two optimization problems are formulated to reduce the impact of OP and optimize the data rate. Our numerical and simulation results are provided to prove the theoretical and analytical analysis. Thanks to these results, a great performance gain can be achieved for both TSR WSN-NOMA and PSR WSN-NOMA if optimal values of TS and PS ratios are found. In addition, the optimized TSR WSN-NOMA outperforms that of PSR WSN-NOMA in terms of OP.Web of Science193art. no. 61

    The perspective of psychology students on the areas of psychology

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    Perception is defined as the result of an awareness process about phenomena, things (living animals, plants, or humans), connections between objects by activities including noticing, observing, differentiating, and acknowledging. A recent study was conducted to investigate the undergraduate’s perception of areas of psychology. This research used the Vietnamese version of the Scale of Interests by Areas of Psychology (EIAPsi), including ten subscales to survey 252 psychology students (57 males and 195 females) from four universities in Vietnam. The findings showed significant effects of university and major on psychology undergraduate’s perception of areas of psychology. Students majoring in Counseling and Clinical Psychology had more general knowledge about the functions and roles of Clinical and Health Psychology and Neuropsychology than other undergraduates. Industrial and Organizational Psychology students had more general knowledge about Organizational Psychology than students in other majors

    Outage and bit error probability analysis in energy harvesting wireless cooperative networks

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    This study focuses on a wireless powered cooperative communication network (WPCCN), which includes a hybrid access point (HAP), a source and a relay. The considered source and relay are installed without embedded energy supply (EES), thus are dependent on energy harvested from signals from the HAP to power their cooperative information transmission (IT). Taking inspiration from this, the author group investigates into a harvest-then-cooperate (HTC) protocol, whereas the source and the relay first harvest the energy from the AP in a downlink (DL) and then collaboratively work in uplink (UL) for IT of the source. For careful evaluation of the system performance, derivations of the approximate closed-form expression of the outage probability (OP) and an average bit error probability ( ABER) for the HTC protocol over Rayleigh fading channels are done. Lastly, the author group performs Monte-Carlo simulations to reassure the numerical results they obtained.Web of Science255746

    Evaluation of a hospital-based integrated model of eye care for diabetic retinopathy assessment: A multimethod study

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    Objectives Diabetic eye disease is a leading cause of blindness but can be mitigated by regular eye assessment. A framework of issues, developed from the literature of barriers to eye assessment, was used to structure an examination of perceptions of a new model of care for diabetic retinopathy from the perspective of staff using the model, and health professionals referring patients to the new service. Design Multimethod: interviews and focus groups, and a separate survey. Setting A new clinic based on an integrated model of care was established at a hospital in outer metropolitan Sydney, Australia in 2017. Funded jointly by Centre for Eye Health (CFEH) and the hospital, the clinic was equipped and staffed by optometrists who work alongside the ophthalmologists in the existing hospital eye clinic. Participants Five (of seven) hospital staff working in the clinic (ophthalmologists and administrative officers) or referring to it from other departments (endocrinologists); nine optometrists from CFEH who developed or worked in the clinic; 10 community-based optometrists as potential referrers. Results The new clinic was considered to have addressed known barriers to eye assessment, including access, assistance for patients unable/unwilling to organise eye checks and efficient management of human resources. The clinic optimised known drivers of this model of care: providing clear scope of practice and protocols for shared care between optometrists and ophthalmologists, good communication between referrers and eye professionals and a collegial approach promoting interprofessional trust. Remaining areas of concern were few referrals from general practitioners, fewer referrals from hospital endocrinologists than expected and issues with stretched administrative capacity. There were also perceived mismatches between the priorities of hospital management and aims of the clinic. Conclusions The new model was considered to have addressed many of the barriers to assessment. While there remain issues with the model, there were also unexpected benefits

    Depleted by Debt: “Green” Microfinance, Over-Indebtedness, and Social Reproduction in Climate-Vulnerable Cambodia

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    The operations of microfinance are exalted in mainstream development thinking as a key means of supporting smallholder farmers facing growing crises of agricultural productivity in the context of daily, ongoing, and often slow-onset climate disasters. Microfinance products and services are claimed to enhance coping and adaptative capacity by facilitating both risk recovery and reduction. Challenging the status quo, this paper brings together original and mixed-method data collected between 2020 and 2022 in Cambodia to critically examine the “green finance” agenda by highlighting the ways in which microfinance contributes to reproducing and exacerbating climate precarity and harm for many. We evidence how credit-taking can lead to more dangerous and individualised efforts to cope with, and adapt to, existing conditions at home, often at the cost of emotional and bodily depletion. By doing so, we contribute to answering calls for connecting literatures and thinking on social reproduction, depletion, and climate change adaptation

    Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway

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    Background & Aims: Infection is a major problem in advanced liver disease secondary to monocyte dysfunction. Elevated prostaglandin (PG)E2 is a mediator of monocyte dysfunction in cirrhosis; thus, we examined PGE2 signalling in outpatients with ascites and in patients hospitalised with acute decompensation to identify potential therapeutic targets aimed at improving monocyte dysfunction. Methods: Using samples from 11 outpatients with ascites and 28 patients hospitalised with decompensated cirrhosis, we assayed plasma levels of PGE2 and lipopolysaccharide (LPS); performed quantitative real-time PCR on monocytes; and examined peripheral blood monocyte function. We performed western blotting and immunohistochemistry for PG biosynthetic machinery expression in liver tissue. Finally, we investigated the effect of PGE2 antagonists in whole blood using polychromatic flow cytometry and cytokine production. Results: We show that hepatic production of PGE2 via the cyclo-oxygenase 1–microsomal PGE synthase 1 pathway, and circulating monocytes contributes to increased plasma PGE2 in decompensated cirrhosis. Transjugular intrahepatic sampling did not reveal whether hepatic or monocytic production was larger. Blood monocyte numbers increased, whereas individual monocyte function decreased as patients progressed from outpatients with ascites to patients hospitalised with acute decompensation, as assessed by Human Leukocyte Antigen (HLA)–DR isotype expression and tumour necrosis factor alpha and IL6 production. PGE2 mediated this dysfunction via its EP4 receptor. Conclusions: PGE2 mediates monocyte dysfunction in decompensated cirrhosis via its EP4 receptor and dysfunction was worse in hospitalised patients compared with outpatients with ascites. Our study identifies a potential drug target and therapeutic opportunity in these outpatients with ascites to reverse this process to prevent infection and hospital admission. Lay summary: Patients with decompensated cirrhosis (jaundice, fluid build-up, confusion, and vomiting blood) have high infection rates that lead to high mortality rates. A white blood cell subset, monocytes, function poorly in these patients, which is a key factor underlying their sensitivity to infection. We show that monocyte dysfunction in decompensated cirrhosis is mediated by a lipid hormone in the blood, prostaglandin E2, which is present at elevated levels, via its EP4 pathway. This dysfunction worsens when patients are hospitalised with complications of cirrhosis compared with those in the outpatients setting, which supports the EP4 pathway as a potential therapeutic target for patients to prevent infection and hospitalisation
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