Design and clinical application of colonoscopy convenient pant

结肠镜检查是诊治肠道疾病的首选方法。随着肠道疾病发病率的增长，越来越多的人群需要接受结肠镜检查。为了方便检查、保护病人隐私及防止受凉等，笔者设计制作了结肠镜检查方便裤，并已经很好地将其应用于临床。Colonoscopy is the first choice for diagnosis and treatment of intestinal diseases. With the growth of the incidence of intestinal disease, more and more people need colonoscopy. In order to inspecting conveniently, protecting patients’ privacy and preventing them from catching a cold, we designed the colonoscopy convenient pant and have applied it into clinic well

Natural plant polyphenols for alleviating oxidative damage in man: Current status and future perspectives

The balance between oxidation and reduction is important for maintaining a healthy biological system. Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) and limited endogenous defense systems, and this imbalance can adversely alter lipids, proteins and DNA, causing a number of human diseases. Thus, exogenous antioxidants that can neutralize the effect of free radicals are needed to diminish the cumulative effects of oxidative damage over human life span. Current research reveals that phenolic compounds in plants possess high antioxidant activity and free radical scavenging capacity and can prevent the body from oxidative damage over human life span. This review focuses on the present understanding of free radicals and antioxidants and their importance in human health and disease. Information about the chemical features of free radicals as well as their deleterious effects on cell structures is reviewed. The chemical structure and anti-oxidative mechanisms of essential polyphenols and their potential health benefits are presented. In addition, the limitation of natural antioxidants and a perspective on likely future trends in this field are also discussed.Keywords: Free radicals, Oxidative stress, Natural antioxidants, Polyphenols, Health benefits, Reactive oxygen species, Reactive nitrogen specie

Enhanced bandwidth nonlinear resonance electromagnetic human motion energy harvester using magnetic-springs and ferrofluid

An enhanced bandwidth nonlinear resonant electromagnetic energy harvester has been designed to harness low frequency energy from basic human motion. Some vertical stacked cylindrical permanent magnets (PMs) constitute the inertial mass of the proposed harvester, which is suspended axially by two magnetic-springs and circumferentially by ferrofluid within a carbon fiber tube. In order to widen the frequency band and improve harvesting efficiency, two PMs are respectively fixed on the two end caps of the carbon fiber tube, so as to form two magnetic-springs with variable stiffness by cooperating with the PM stack. The self-assembled ferrofluid around the PM stack acts as its bearing system to minimize any friction during its movement. Copper wire are wrapped outside the tube to form the armature winding. The stiffness characteristic of the magnetic-springs and the optimum equilibrium position and number of windings have been determined by finite element method (FEM) analysis. As a proof of concept, a portable prototype of the proposed energy harvester that weighs 110g and with a volume of only 37.7cm $^3$ is fabricated. A series of experiments are carried out and the results show that the frequency band of the harvester becomes wider as the external vibration intensity increases. In addition, the effectiveness of ferrofluid in reducing friction is demonstrated under walking and running conditions. Without ferrofluid, the maximum average outputs are 10.15 mW and 32.53 mW respectively for walking and running. With ferrofluid, the maximum outputs are 17.72 mW and 54.61 mW, representing an increase of 74.58% and 67.88%, respectively. Furthermore, the prototype exhibits an average power density of 1.45 mW/cm $^3$ during running motions, which compares favorably with existing harvesters used in low power wearable devices

Global Slim Accretion Disk Solutions Revisited

We show that there exists a maximal possible accretion rate, beyond which global slim disk solutions cannot be constructed because in the vertical direction the gravitational force would be unable to balance the pressure force to gather the accreted matter. The principle for this restriction is the same as that for the Eddington luminosity and the corresponding critical accretion rate, which were derived for spherical accretion by considering the same force balance in the radial direction. If the assumption of hydrostatic equilibrium is waived and vertical motion is included, this restriction may become even more serious as the value of the maximal possible accretion rate becomes smaller. Previous understanding in the literature that global slim disk solutions could stand for any large accretion rates is due to the overestimation of the vertical gravitational force by using an approximate potential. For accretion flows with large accretion rates at large radii, outflows seem unavoidable in order for the accretion flow to reduce the accretion rate and follow a global solution till the central black hole.Comment: Accepted by Ap

Effect of Ridge Width on the Lasing Characteristics of Triangular and Rectangular InAs/In0.53Ga0.47As Quantum Well Lasers

The lasing characteristics of InP-based InAs/In0.53Ga0.47As quantum well (QW) lasers with different ridge widths are investigated. Two groups of lasers are grown for comparison, one with active triangular QW regions and the other with rectangular QW regions. Their output powers, characteristic temperatures (T0), external differential quantum efficiencies (ηd) and junction temperatures (Tj) are analyzed and compared. The parameter of ridge width is found to play an important role in the performance of the lasers. In triangular QW lasers, by broadening the ridge width from 8 to 12\ua0μm, output power and ηd of the lasers are decreased for the temperature range of 100–320\ua0K due to heating effect. But by broadening the ridge width from 8 to 100\ua0μm in rectangular QW lasers, output power has about 3.5 time increase at 100\ua0K and ηd also has a little increase for temperatures from 100 to 180\ua0K due to much larger emission area and much faster heat dissipation. Tj, the real temperature of the active region, is also found to have accelerated increase at high injection current and heat sink temperature. Besides, compared to the rectangular QW laser of the same ridge width, the improved thermal performance of triangular QW laser is also demonstrated

Delisheng, a Chinese medicinal compound, exerts anti-proliferative and pro-apoptotic effects on HepG2 cells through extrinsic and intrinsic pathways

The anti-proliferative, cytotoxic and apoptogenic activities of delisheng, a Chinese medicinal compound, has been investigated. In this study, the hepatocarcinoma cell line (HepG2) and the liver cell line (L-02) were exposed to delisheng (6.25, 50 and 100 μl/ml). Delisheng suppressed the proliferation and viability of normal liver L-02 cells slightly, but strongly inhibited the proliferation and viability of hepatocarcinoma HepG2 cells. The flow cytometric analysis of HepG2 cells demonstrated that delisheng primarily arrested the HepG2 cells at the G1 phase of the cell cycle. Annexin V-FITC/PI staining corroborates the apoptogenic nature of delisheng on HepG2 cells. The anti-proliferative and pro-apoptotic effect of delisheng in HepG2 cells was associated with changes in the Bcl-2/Bax ratio and the induction of caspase-mediated apoptosis. Upregulation of DR5 expression was observed in HepG2 cells after treatment with delisheng. The findings from the present study suggest that delisheng has selective cytotoxic activities against HepG2 cells. Delisheng triggered time- and dose-dependent apoptosis in HepG2 cells by activating the mitochondria-mediated and death receptor-mediated apoptotic pathways

Microcrystalline Dolomite in a Middle Permian Volcanic Lake: Insights on Primary Dolomite Formation in a Non-Evaporitic Environment

Lacustrine dolomite nucleation commonly occurs in modern and Neogene evaporitic alkaline lakes. As a result, ancient lacustrine microcrystalline dolomite has been conventionally interpreted to be formed in evaporitic environments. This study, however, suggests a non-evaporitic origin of dolomite precipitated in a volcanic–hydrothermal lake, where hydrothermal and volcanic processes interacted. The dolomite occurs in lacustrine fine-grained sedimentary rocks in the middle Permian Lucaogou Formation in the Santanghu intracontinental rift basin, north-west China. Dolostones are composed mainly of nano-sized to micron-sized dolomite with a euhedral to subhedral shape and a low degree of cation ordering, and are interlaminated and intercalated with tuffaceous shale. Non-dolomite minerals, including quartz, alkaline feldspars, smectite and magnesite mix with the dolomite in various proportions. The 87Sr/86Sr ratios (0.704528 to 0.705372, average = 0.705004) and δ26Mg values (−0.89 to −0.24‰, average = −0.55‰) of dolostones are similar to those of mantle rocks, indicating that the precipitates mainly originated from fluids that migrated upward from the mantle and were subject to water–rock reactions at a great depth. The δ18O values (−3.1 to −22.7‰, average = −14.0‰) of the dolostones indicate hydrothermal influence. The trace and rare earth element concentrations suggest a saline, anoxic and volcanic–hydrothermally-influenced subaqueous environment. In this subaqueous environment of Lucaogou lake, locally high temperatures and a supply of abundant Mg2+ from a deep source induced by volcanic–hydrothermal activity formed favourable chemical conditions for direct precipitation of primary dolomite. This study\u27s findings deepen the understanding of the origin and processes of lacustrine primary dolomite formation and provide an alternative possibility for environmental interpretations of ancient dolostones

AutoHint: Automatic Prompt Optimization with Hint Generation

This paper presents AutoHint, a novel framework for automatic prompt engineering and optimization for Large Language Models (LLM). While LLMs have demonstrated remarkable ability in achieving high-quality annotation in various tasks, the key to applying this ability to specific tasks lies in developing high-quality prompts. Thus we propose a framework to inherit the merits of both in-context learning and zero-shot learning by incorporating enriched instructions derived from input-output demonstrations to optimize original prompt. We refer to the enrichment as the hint and propose a framework to automatically generate the hint from labeled data. More concretely, starting from an initial prompt, our method first instructs a LLM to deduce new hints for selected samples from incorrect predictions, and then summarizes from per-sample hints and adds the results back to the initial prompt to form a new, enriched instruction. The proposed method is evaluated on the BIG-Bench Instruction Induction dataset for both zero-shot and few-short prompts, where experiments demonstrate our method is able to significantly boost accuracy for multiple tasks

Transfer matrix method for the determination of the natural vibration characteristics of realistic thrusting launch vehicle—Part

The feasibility of using the transfer matrix method (TMM) to compute the natural vibration characteristics of a flexible rocket/satellite launch vehicle is explored theoretically. In the approach to the problem, a nonuniform free-free Timoshenko and Euler-Bernoulli beamlike structure is modeled. A provision is made to take into consideration the effects of shear deformation and rotary inertia. Large thrust-to-weight ratio leads to large axial accelerations that result in an axial inertia load distribution from nose to tail which causes the development of significant compressive forces along the length of the launch vehicle. Therefore, it is important to take into account this effect in the transverse vibration model. Once the transfer matrix of a single component has been obtained, the product of all component matrices composes the matrix of the entire structure. The frequency equation and mode shape are formulated in terms of the elements of the structural matrices. Flight test and analytical results validate the present TMM formulas

Cyclin D1 integrates G9a-mediated histone methylation.

Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. The mechanisms governing the recruitment of G9a to distinct subcellular sites, into chromatin or to LAD, is not known. The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates pRB and NRF1 thereby governing cell-cycle progression and mitochondrial metabolism. Herein, we show that cyclin D1 enhanced H3K9 dimethylation though direct association with G9a. Endogenous cyclin D1 was required for the recruitment of G9a to target genes in chromatin, for G9a-induced H3K9me2 of histones, and for NL-LAD interaction. The finding that cyclin D1 is required for recruitment of G9a to target genes in chromatin and for H3K9 dimethylation, identifies a novel mechanism coordinating protein methylation