Saddle-Node bifurcations in classical and memristive circuits

This paper addresses a systematic characterization of saddle-node bifurcations in nonlinear electrical and electronic circuits. Our approach is a circuit-theoretic one, meaning that the bifurcation is analyzed in terms of the devices’ characteristics and the graph-theoretic properties of the digraph underlying the circuit. The analysis is based on a reformulation of independent interest of the saddle-node theorem of Sotomayor for semiexplicit index one differential-algebraic equations (DAEs), which define the natural context to set up nonlinear circuit models. The bifurcation is addressed not only for classical circuits, but also for circuits with memristors. The presence of this device systematically leads to nonisolated equilibria, and in this context the saddle-node bifurcation is shown to yield a bifurcation of manifolds of equilibria; in cases with a single memristor, this phenomenon describes the splitting of a line of equilibria into two, with different stability properties

Comparison and Assessment of Two Emission inventories for the Madrid Region

Emission inventories are databases that aim to describe the polluting activities that occur across a certain geographic domain. According to the spatial scale, the availability of information will vary as well as the applied assumptions, which will strongly influence its quality, accuracy and representativeness. This study compared and contrasted two emission inventories describing the Greater Madrid Region (GMR) under an air quality simulation approach. The chosen inventories were the National Emissions Inventory (NEI) and the Regional Emissions Inventory of the Greater Madrid Region (REI). Both of them were used to feed air quality simulations with the CMAQ modelling system, and the results were compared with observations from the air quality monitoring network in the modelled domain. Through the application of statistical tools, the analysis of emissions at cell level and cell – expansion procedures, it was observed that the National Inventory showed better results for describing on – road traffic activities and agriculture, SNAP07 and SNAP10. The accurate description of activities, the good characterization of the vehicle fleet and the correct use of traffic emission factors were the main causes of such a good correlation. On the other hand, the Regional Inventory showed better descriptions for non – industrial combustion (SNAP02) and industrial activities (SNAP03). It incorporated realistic emission factors, a reasonable fuel mix and it drew upon local information sources to describe these activities, while NEI relied on surrogation and national datasets which leaded to a poorer representation. Off – road transportation (SNAP08) was similarly described by both inventories, while the rest of the SNAP activities showed a marginal contribution to the overall emissions

Functional diversity of motoneurons in the oculomotor system

Extraocular muscles contain two types of muscle fibers according to their innervation pattern: singly innervated muscle fibers (SIFs), similar to most skeletal muscle fibers, and multiply innervated muscle fibers (MIFs). Morphological studies have revealed that SIF and MIF motoneurons are segregated anatomically and receive different proportions of certain afferents, suggesting that while SIF motoneurons would participate in the whole repertoire of eye movements, MIF motoneurons would contribute only to slow eye movements and fixations. We have tested that proposal by performing single-unit recordings, in alert behaving cats, of electrophysiologically identified MIF and SIF motoneurons in the abducens nucleus. Our results show that both types of motoneuron discharge in relation to eye position and velocity, displaying a tonic–phasic firing pattern for different types of eye movement (saccades, vestibulo-ocular reflex, vergence) and gaze-holding. However, MIF motoneurons presented an overall reduced firing rate compared with SIF motoneurons, and had significantly lower recruitment threshold and also lower eye position and velocity sensitivities. Accordingly, MIF motoneurons could control mainly gaze in the off-direction, when less force is needed, whereas SIF motoneurons would contribute to increase muscle tension progressively toward the on-direction as more force is required. Anatomically, MIF and SIF motoneurons distributed intermingled within the abducens nucleus, with MIF motoneurons being smaller and having a lesser somatic synaptic coverage. Our data demonstrate the functional participation of both MIF and SIF motoneurons in fixations and slow and phasic eye movements, although their discharge properties indicate a functional segregation.Ministerio de Ciencia, Innovación y Universidades – Fondo Europeo de Desarrollo Regional (BFU2015-64515-P)Junta de Andalucía (BIO-297

Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population

BACKGROUND: Recent data indicate that chronic use of coxibs leads to an increased occurrence of thrombotic cardiovascular events. This raises the question as to whether traditional non-steroidal anti-inflammatory drugs (tNSAIDs) might also produce similar hazards. Our aim has been to evaluate the association between the chronic use of tNSAIDs and the risk of myocardial infarction (MI) in patients. METHODS: We performed a nested case-control analysis with 4,975 cases of acute MI and 20,000 controls, frequency matched to cases by age, sex, and calendar year. RESULTS: Overall, current use of tNSAID was not associated with an increased risk of MI (RR:1.07;95%CI: 0.95–1.21). However, we found that the relative risk (RR) of MI for durations of tNSAID treatment of >1 year was 1.21 (95% CI, 1.00–1.48). The corresponding RR was 1.34 (95% CI, 1.06–1.70) for non-fatal MI. The effect was independent from dose. The small risk associated with long-term use of tNSAIDs was observed among patients not taking low-dose aspirin (RR: 1.29; 95% CI, 1.01–1.65). The effect of long-term use for individual tNSAIDs ranged from a RR of 0.87 (95% CI, 0.47–1.62) with naproxen to 1.38 (95% CI, 1.00–1.90) with diclofenac. CONCLUSION: This study adds support to the hypothesis that chronic treatment with some tNSAIDs is associated with a small increased risk of non-fatal MI. Our data are consistent with a substantial variability in cardiovascular risks between individual tNSAIDs

Hyperbolicity of direct products of graphs

It is well-known that the different products of graphs are some of the more symmetric classes of graphs. Since we are interested in hyperbolicity, it is interesting to study this property in products of graphs. Some previous works characterize the hyperbolicity of several types of product graphs (Cartesian, strong, join, corona and lexicographic products). However, the problem with the direct product is more complicated. The symmetry of this product allows us to prove that, if the direct product G(1) x G(2) is hyperbolic, then one factor is bounded and the other one is hyperbolic. Besides, we prove that this necessary condition is also sufficient in many cases. In other cases, we find (not so simple) characterizations of hyperbolic direct products. Furthermore, we obtain good bounds, and even formulas in many cases, for the hyperbolicity constant of the direct product of some important graphs (as products of path, cycle and even general bipartite graphs).This work was supported in part by four grants from Ministerio de Economía y Competititvidad (MTM2012-30719, MTM2013-46374-P, MTM2016-78227-C2-1-P and MTM2015-69323-REDT), Spain

Guidelines for Weighting Factors Adjustment in Finite State Model Predictive Control of Power Converters and Drives

INTERNATIONAL CONFERENCE ON INDUSTRIAL TECHNOLOGY () (.2009.VICTORIA, AUSTRALIA)Model Predictive Control with a finite control set has emerged as a promising control tool for power converters and drives. One of the major advantages is the possibility to control several system variables with a single control law, by including them with appropriate weighting factors. However, at the present state of the art, these coefficients are determined empirically. There is no analytical or numerical method proposed yet to obtain an optimal solution. In addition, the empirical method is not always straightforward, and no procedures have been reported. This paper presents a first approach to a set of guidelines that reduce the uncertainty of this process. First a classification of different types of cost functions and weighting factors is presented. Then the different steps of the empirical process are explained. Finally, results for several power converters and drives applications are analyzed, which show the effectiveness of the proposed guidelines to reach appropriate weighting factors and control performance

Impact of a teacher-training MOOC on the Pedagogy of Death during the pandemic

The objective of this study was to determine the impact of a MOOC on the attitudes of pre-service and in-service teachers toward education on death. The study adopted a pre- and post-test design. Participants (N = 139) answered the Death Education Attitudes Scale-Teachers (DEAS-T) questionnaire at the beginning and end of the course. The results confirmed significant differences between the pre- and post-course applications in the three scale factors—need for training in the Pedagogy of Death, inclusion of death in education, and educational awareness of death. Open-access, free, mass training through a MOOC could have a positive impact on attitudes toward death education among both pre- and in-service teacher

Domesticated Animals as Reservoirs of Leptospirosis in Camaguey, the Pig Factor

The aim of this study was to evaluate the role of domesticated animals, particularly pigs, as reservoirs of leptospirosis in the province of Camaguey. The sera from 2 617 equines, 1 820 pigs, 75 ovines and caprine, and 69 canines in Camaguey were analyzed by microagglutination. Serovars Icterohaemorrhagiae, Canicola, Ballum, Australis, Pomona and Tarassovi were used as antigens for horses, pigs and dogs; whereas Icterohaemorrhagiae, Canicola, Ballum, Pomona, Hebdomadis and Sejroe were used for bovines and ovine-caprine. The variable studied was antibody proportion per species. The inclusion of Hardjo, Bratislava, Sejroe and Grippotyphosa for serum screenings in swine contributed to better understanding of the species as reservoir of Leptospirosis in the province. Due to the growing number of these animals in urban adjacent areas, this result is a warning about the underlying risk of epidemics transmitted to humans

Domesticated Animals as Reservoirs of Leptospirosis in Camaguey, the Pig Factor

The aim of this study was to evaluate the role of domesticated animals, particularly pigs, as reservoirs of leptospirosis in the province of Camaguey. The sera from 2 617 equines, 1 820 pigs, 75 ovines and caprine, and 69 canines in Camaguey were analyzed by microagglutination. Serovars Icterohaemorrhagiae, Canicola, Ballum, Australis, Pomona and Tarassovi were used as antigens for horses, pigs and dogs; whereas Icterohaemorrhagiae, Canicola, Ballum, Pomona, Hebdomadis and Sejroe were used for bovines and ovine-caprine. The variable studied was antibody proportion per species. The inclusion of Hardjo, Bratislava, Sejroe and Grippotyphosa for serum screenings in swine contributed to better understanding of the species as reservoir of Leptospirosis in the province. Due to the growing number of these animals in urban adjacent areas, this result is a warning about the underlying risk of epidemics transmitted to humans