An orbit-preserving discretization of the classical Kepler problem

We present a remarkable discretization of the classical Kepler problem which preserves its trajectories and all integrals of motion. The points of any discrete orbit belong to an appropriate continuous trajectory.Comment: 7 page

Long-time behaviour of discretizations of the simple pendulum equation

We compare the performance of several discretizations of the simple pendulum equation in a series of numerical experiments. The stress is put on the long-time behaviour. We choose for the comparison numerical schemes which preserve the qualitative features of solutions (like periodicity). All these schemes are either symplectic maps or integrable (preserving the energy integral) maps, or both. We describe and explain systematic errors (produced by any method) in numerical computations of the period and the amplitude of oscillations. We propose a new numerical scheme which is a modification of the discrete gradient method. This discretization preserves (almost exactly) the period of small oscillations for any time step.Comment: 41 pages, including 18 figures and 4 table

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets.

RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization

No patient left behind : The promise of immune priming with epigenetic agents

Checkpoint inhibitors, monoclonal antibodies that inhibit PD-1 or CTLA-4, have revolutionized the treatment of multiple cancers. Despite the enthusiasm for the clinical successes of checkpoint inhibitors, and immunotherapy, in general, only a minority of patients with specific tumor types actually benefit from treatment. Emerging evidence implicates epigenetic alterations as a mechanism of clinical resistance to immunotherapy. This review presents evidence for that association, summarizes the epi-based mechanisms by which tumors evade immunogenic cell death, discusses epigenetic modulation as a component of an integrated strategy to boost anticancer T cell effector function in relation to a tumor immunosuppression cycle and, finally, makes the case that the success of this no-patient-left-behind strategy critically depends on the toxicity profile of the epigenetic agent(s).Peer reviewe

Cosmological parameters from large scale structure - geometric versus shape information

The matter power spectrum as derived from large scale structure (LSS) surveys contains two important and distinct pieces of information: an overall smooth shape and the imprint of baryon acoustic oscillations (BAO). We investigate the separate impact of these two types of information on cosmological parameter estimation, and show that for the simplest cosmological models, the broad-band shape information currently contained in the SDSS DR7 halo power spectrum (HPS) is by far superseded by geometric information derived from the baryonic features. An immediate corollary is that contrary to popular beliefs, the upper limit on the neutrino mass m_\nu presently derived from LSS combined with cosmic microwave background (CMB) data does not in fact arise from the possible small-scale power suppression due to neutrino free-streaming, if we limit the model framework to minimal LambdaCDM+m_\nu. However, in more complicated models, such as those extended with extra light degrees of freedom and a dark energy equation of state parameter w differing from -1, shape information becomes crucial for the resolution of parameter degeneracies. This conclusion will remain true even when data from the Planck surveyor become available. In the course of our analysis, we introduce a new dewiggling procedure that allows us to extend consistently the use of the SDSS HPS to models with an arbitrary sound horizon at decoupling. All the cases considered here are compatible with the conservative 95%-bounds \sum m_\nu < 1.16 eV, N_eff = 4.8 \pm 2.0.Comment: 18 pages, 4 figures; v2: references added, matches published versio

Texas Parks & Wildlife

Magazine discussing natural resources, parks, hunting and fishing, and other information related to the outdoors in Texas

Texas Parks & Wildlife

Magazine discussing natural resources, parks, hunting and fishing, and other information related to the outdoors in Texas

Texas Parks & Wildlife

Magazine discussing natural resources, parks, hunting and fishing, and other information related to the outdoors in Texas

Texas Parks & Wildlife

Magazine discussing natural resources, parks, hunting and fishing, and other information related to the outdoors in Texas

Texas Parks & Wildlife

Magazine discussing natural resources, parks, hunting and fishing, and other information related to the outdoors in Texas