Impact of Inter-Country Distances on International Tourism

Tourism is a worldwide practice with international tourism revenues increasing from US\$495 billion in 2000 to US\$1340 billion in 2017. Its relevance to the economy of many countries is obvious. Even though the World Airline Network (WAN) is global and has a peculiar construction, the International Tourism Network (ITN) is very similar to a random network and barely global in its reach. To understand the impact of global distances on local flows, we map the flow of tourists around the world onto a complex network and study its topological and dynamical balance. We find that although the WAN serves as infrastructural support for the ITN, the flow of tourism does not correlate strongly with the extent of flight connections worldwide. Instead, unidirectional flows appear locally forming communities that shed light on global travelling behaviour inasmuch as there is only a 15% probability of finding bidirectional tourism between a pair of countries. We conjecture that this is a consequence of one-way cyclic tourism by analyzing the triangles that are formed by the network of flows in the ITN. Finally, we find that most tourists travel to neighbouring countries and mainly cover larger distances when there is a direct flight, irrespective of the time it takes

The development of a temporal-BRDF model-based approach to change detection, an application to the identification and delineation of fire affected areas.

Although large quantities of southern Africa burn every year, minimal information is available relating to the fire regimes of this area. This study develops a new, generic approach to change detection, applicable to the identification of land cover change from high temporal and moderate spatial resolution satellite data. Traditional change detection techniques have several key limitations which are identified and addressed in this work. In particular these approaches fail to account for directional effects in the remote sensing signal introduced by variations in the solar and sensing geometry, and are sensitive to underlying phenological changes in the surface as well as noise in the data due to cloud or atmospheric contamination. This research develops a bi-directional, model-based change detection algorithm. An empirical temporal component is incorporated into a semi-empirical linear BRDF model. This may be fitted to a long time series of reflectance with less sensitivity to the presence of underlying phenological change. Outliers are identified based on an estimation of noise in the data and the calculation of uncertainty in the model parameters and are removed from the sequence. A "step function kernel" is incorporated into the formulation in order to detect explicitly sudden step-like changes in the surface reflectance induced by burning. The change detection model is applied to the problem of locating and mapping fire affected areas from daily moderate spatial resolution satellite data, and an indicator of burn severity is introduced. Monthly burned area datasets for a 2400km by 1200km area of southern Africa detailing the day and severity of burning are created for a five year period (2000-2004). These data are analysed and the fire regimes of southern African ecosystems during this time are characterised. The results highlight the extent of the burning which is taking place within southern Africa, with between 27-32% of the study area burning during each of the five years of observation. Higher fire frequencies are exhibited by savanna and grassland ecosystems, while more dense vegetation types such as shrublands and deciduous broadleaf forests burn less frequently. In addition the areas which burn more frequently do so with a greater severity, with a positive relationship identified between the frequency and the severity of burning

Post-Tracheal Extubation Negative Pressure Pulmonary Edema

O edema pulmonar de pressão negativa (EPPN) também descrito na literatura como edema agudo do pulmão pós-obstrutivo ou pós-extubação traqueal, é uma entidade rara, com uma incidência de aproximadamente 0.1 % em doentes anestesiados. Os autores descrevem o caso, ocorrido após extubação traqueal, de um doente submetido a orquidectomia por via laparoscópica sob anestesia geral balanceada. Relatam a fisiopatologia, o padrão radiológico e broncoscópico e as medidas terapêuticas instituídas

Vibration measurements on small to medium single-span railway bridges

Due to the need for increasing train speeds several existing small to medium span bridges in the track Linz-Wels (Austria) were re-evaluated. In a preliminary numerical calculation, considering conservative values for the dynamic parameters, very high vertical accelerations were computed for some of those structures. An experimental program was thus carried out in order to get a better estimation for the dynamic behaviour of the bridges, concerning mainly the first vertical eigenfrequency and the corresponding viscous damping. The paper reports on the results of this experimental investigation and identifies some areas where further research is necessary

Fractional bioheat equation

In this work we develop a new mathematical model for the Pennes’ bioheat equation assuming a fractional time derivative of single order. A numerical method for the solu- tion of such equations is proposed, and, the suitability of the new model for modelling real physical problems is studied and discussedCOMPETE, FEDER and Fundação para a Ciência e a Tecnologia (the Portuguese Foundation for Science and Technology (FCT)) through Projects UID/CTM/50025/2013, PTDC/EME- MFE/113988/2009 and EXPL/CTM-POL/1299/2013. M. Rebelo acknowledge financial funding by the Portuguese Foundation for Science and Technology through the project PEstOE/MAT/UI0297/2013 (Centro de Matemática e Aplicacões

Radiocarbon and blue optically stimulated luminescence chronologies of the Oitavos consolidated dune (Western Portugal)

The dune of Oitavos, the underlying paleosol, and Helix sp. gastropod shells found within the paleosol were dated using a combination of radiocarbon and blue optically stimulated luminescence (OSL). The organic component of the paleosol produced a significantly older age (~20,000 cal BP) than the OSL age measurement (~15,000 yr), while 14C age measurements on the inorganic component and the gastropods produced ages of ~35,000 yr and ~34,000 yr, respectively. Rare-earth element analyses provide evidence that the gastropods incorporate geological carbonate, making them an unreliable indicator of the age of the paleosol. We propose that the 14C age of the small organic component of the paleosol is also likely to be unreliable due to incorporation of residual material. The OSL age measurement of the upper paleosol (~15,000 yr) is consistent with the age for the base of the dune (~14,500 yr). The younger OSL age for the top of the dune (~12,000 yr) suggests that it was built up by at least 2 sand pulses or that there was a remobilization of material at the top during its evolution, prior to consolidation

Fractional pennes' bioheat equation: Theoretical and numerical studies

Accepted for publication in Fractional calculus and applied analysisOriginally published in the journal Fract. Cal. Appl. Anal. Vol. 18 No. 4 / 2015 / pp.1080–1106 / DOI 10.1515/fca-2015-0062. The original publication is available at: http://www.degruyter.com/view/j/fca.2015.18.issue-4/fca-2015-0062/fca-2015-0062.xml?rskey=sWWcn0&result=1In this work we provide a new mathematical model for the Pennes’ bioheat equation, assuming a fractional time derivative of single order. Alternative versions of the bioheat equation are studied and discussed, to take into account the temperature-dependent variability in the tissue perfusion, and both finite and infinite speed of heat propagation. The proposed bio heat model is solved numerically using an implicit finite difference scheme that we prove to be convergent and stable. The numerical method proposed can be applied to general reaction diffusion equations, with a variable diffusion coefficient. The results obtained with the single order fractional model, are compared with the original models that use classical derivatives.The authors L.L. Ferras and J. M. Nobrega acknowledge financial funding by FEDER through the COMPETE 2020 Programme and by FCT- Portuguese Foundation for Science and Technology under the projects UID/CTM/50025/2013 and EXPL/CTM-POL/1299/2013. L.L. Ferras acknowledges financial funding by the Portuguese Foundation for Science and Technology through the scholarship SFRH/BPD/100353/2014. M. Rebelo acknowledges financial funding by the Portuguese Foundation for Science and Technology through the project UID/MAT/00297/2013

Global embedding of the Kerr black hole event horizon into hyperbolic 3-space

An explicit global and unique isometric embedding into hyperbolic 3-space, H^3, of an axi-symmetric 2-surface with Gaussian curvature bounded below is given. In particular, this allows the embedding into H^3 of surfaces of revolution having negative, but finite, Gaussian curvature at smooth fixed points of the U(1) isometry. As an example, we exhibit the global embedding of the Kerr-Newman event horizon into H^3, for arbitrary values of the angular momentum. For this example, considering a quotient of H^3 by the Picard group, we show that the hyperbolic embedding fits in a fundamental domain of the group up to a slightly larger value of the angular momentum than the limit for which a global embedding into Euclidean 3-space is possible. An embedding of the double-Kerr event horizon is also presented, as an example of an embedding which cannot be made global.Comment: 16 pages, 13 figure

Influenza A(H1N1)pdm09 Resistance and Cross-Decreased Susceptibility to Oseltamivir and Zanamivir Antiviral Drugs

Neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are currently the only effective antiviral drugs available worldwide for the management of influenza. The potential development of resistance is continually threatening their use, rationalizing and highlighting the need for a close and sustained evaluation of virus susceptibility. This study aimed to analyze and characterize the phenotypic and genotypic NAIs susceptibility profiles of A(H1N1)pdm09 viruses circulating in Portugal from 2009 to 2010/2011. A total of 144 cases of A(H1N1)pdm09 virus infection from community and hospitalized patients were studied, including three suspected cases of clinical resistance to oseltamivir. Oseltamivir resistance was confirmed for two of the suspected cases. Neuraminidase (NA) H275Y resistant marker was found in viruses from both cases but for one it was only present in 26.2% of virus population, raising questions about the minimal percentage of resistant virus that should be considered relevant. Cross-decreased susceptibility to oseltamivir and zanamivir (2-4 IC50 fold-change) was detected on viruses from two potentially linked community patients from 2009. Both viruses harbored the NA I223V mutation. NA Y155H mutation was found in 18 statistical non-outlier viruses from 2009, having no impact on virus susceptibility. The mutations at NA N369K and V241I may have contributed to the significantly higher baseline IC50 value obtained to oseltamivir for 2010/2011 viruses, compared to viruses from the pandemic period. These results may contribute to a better understanding of the relationship between phenotype and genotype, which is currently challenging, and to the global assessment of A(H1N1)pdm09 virus susceptibility profile and baseline level to NAIs

Melanin nanoparticles as a promising tool for biomedical applications – a review

Melanin is a biopolymer of easy and cheap availability that can be found among the living organisms and excels for its biocompatibility and biodegradability properties, along with scavenging abilities, metal chelation and electronic conductance. This biomaterial can act as a nanocarrier or agent itself to be used in diverse biomedical applications, such as imaging, controlled drug release, bioengineering and bioelectronics, antioxidant applications and theranostics. In this review, the melanin source and structure, its physicochemical properties, melanin-like polymers as well as the differences among those will be elucidated. The focus will be the discussion of the current approaches that apply melanin nanoparticles (MNPs) and melanin-like nanoparticles (MLNPs) in the biomedical field, to which promising capabilities have been attributed, regarding optoelectronic, photoconductivity and photoacoustic. The use of these nanoparticles, in the last 10 years, in topics as drug delivery or theranostics will be detailed and the major achievements will be discussed. Overall, we anticipate that melanin can drive us toward a new paradigm in medical diagnostics and treatments, since applying melanin features possibly its use as a theranostics nanocarrier agent, not only for diagnostics, but also for photothermal therapy and controlled drug release through chemotherapy.VM Correlo would like to acknowledge FROnTHERA (NORTE-01–0145-FEDER-0000232) project. RRebelo would like to acknowledge BREAST-IT PTDC/BTM-ORG/28168/2017 project